SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		7 / 12 TRP A  25
TYR A  78
ARG A 191
ASP A 193
GLU A 219
TRP A 221
HIS A 293
 None
 0.69A 1mxdA-1gcyA:
35.9		 1mxdA-1gcyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		7 / 12 TRP A  25
TYR A  78
HIS A 117
ARG A 191
ASP A 193
TRP A 221
HIS A 293
 None
 0.42A 1mxdA-1gcyA:
35.9		 1mxdA-1gcyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		7 / 12 TRP A  25
TYR A  78
HIS A 117
PHE A 156
ARG A 191
ASP A 193
HIS A 293
 None
 0.73A 1mxdA-1gcyA:
35.9		 1mxdA-1gcyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 ASP A  62
HIS A 117
ASP A 193
 None
 0.79A 1nw5A-1gcyA:
undetectable		 1nw5A-1gcyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 VAL A  58
HIS A 307
GLU A 219
ASP A 112
 None
 1.27A 1s3zA-1gcyA:
1.1
1s3zB-1gcyA:
undetectable		 1s3zA-1gcyA:
14.53
1s3zB-1gcyA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		5 / 8 VAL A 331
THR A 328
PRO A 329
TYR A 319
LEU A 323
 None
 1.50A 1z2bB-1gcyA:
undetectable		 1z2bB-1gcyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 ASP A 291
ASP A 334
ASP A 294
 None
 0.77A 2igtB-1gcyA:
undetectable		 2igtB-1gcyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 4 ASP A 291
ASP A 334
ASP A 294
GLY A 303
 None
 1.03A 2igtC-1gcyA:
undetectable		 2igtC-1gcyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 THR A 328
PRO A 329
VAL A 330
ALA A  53
 None
 1.06A 2v41G-1gcyA:
undetectable
2v41H-1gcyA:
undetectable		 2v41G-1gcyA:
18.15
2v41H-1gcyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 8 ILE A 127
LEU A 129
GLY A 172
TRP A 206
 None
 0.79A 3w1wA-1gcyA:
undetectable		 3w1wA-1gcyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 7 PRO A 326
VAL A 376
ALA A 374
PHE A 365
 None
 1.12A 4lb2A-1gcyA:
undetectable		 4lb2A-1gcyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 5 PRO A 329
GLY A 327
ASP A 112
ASP A 255
 None
 1.12A 4n48B-1gcyA:
undetectable		 4n48B-1gcyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		5 / 12 LEU A  95
ASN A 180
ALA A 187
VAL A 109
ALA A  99
 None
 1.13A 4x1kD-1gcyA:
3.6		 4x1kD-1gcyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		5 / 12 SER A  52
ILE A  46
LEU A 102
GLY A 103
GLY A 106
 None
 1.10A 4yvgA-1gcyA:
undetectable		 4yvgA-1gcyA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		5 / 12 VAL A 330
PHE A  51
LEU A  95
LEU A 110
ALA A 187
 None
 1.19A 5fctB-1gcyA:
0.0		 5fctB-1gcyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 LEU A 274
LEU A 258
TRP A 270
 None
 0.86A 5nwuA-1gcyA:
undetectable		 5nwuA-1gcyA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		5 / 11 ASP A  49
ILE A  46
ILE A 345
GLY A 342
VAL A 331
 None
 0.79A 5twjD-1gcyA:
undetectable		 5twjD-1gcyA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		5 / 12 GLY A 153
PRO A 143
GLY A 144
ASP A 151
ASN A 164
 CA  A 528 ( 4.5A)
None
None
CA  A 528 (-2.3A)
None
 1.35A 5yniA-1gcyA:
undetectable		 5yniA-1gcyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		6 / 12 TRP A  25
TYR A  78
HIS A 117
GLU A 226
ASP A 193
HIS A 293
 None
 0.60A 6ag0A-1gcyA:
32.7		 6ag0A-1gcyA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 7 TYR A 198
TRP A 206
CSS A 251
CSS A 216
 None
 1.44A 6cnkB-1gcyA:
undetectable
6cnkC-1gcyA:
undetectable		 6cnkB-1gcyA:
10.75
6cnkC-1gcyA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		4 / 6 PHE A 289
ILE A 322
ASN A 275
ASP A 255
 None
 1.24A 6dhbA-1gcyA:
0.0		 6dhbA-1gcyA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE
(Pseudomonas
stutzeri) 		3 / 3 LEU A 274
GLY A 327
PHE A 215
 None
 0.52A 6exiC-1gcyA:
undetectable		 6exiC-1gcyA:
10.00