SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		5 / 12 GLY A 154
GLY A 156
SER A 157
ALA A 161
LEU A 162
 None
 0.68A 1i9gA-1gdhA:
6.6		 1i9gA-1gdhA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 5 ALA A  19
ASN A 304
ILE A 307
ASP A 308
 None
 1.13A 1yc2D-1gdhA:
3.4		 1yc2D-1gdhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		5 / 12 LEU A 197
LEU A 200
LEU A 150
LEU A 209
THR A 225
 None
 1.09A 1zucB-1gdhA:
undetectable		 1zucB-1gdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		3 / 3 ALA A 161
THR A 102
PHE A 155
 None
SO4  A 322 (-3.7A)
None
 0.78A 2c6nB-1gdhA:
0.0		 2c6nB-1gdhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 6 LEU A 320
ALA A  97
HIS A  81
ASP A  80
 None
 1.12A 2dpzA-1gdhA:
undetectable		 2dpzA-1gdhA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		5 / 12 GLY A 154
GLY A 156
SER A 157
ALA A 161
LEU A 162
 None
 0.73A 2yvlA-1gdhA:
6.9		 2yvlA-1gdhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 5 GLU A 143
GLY A 142
TYR A 260
GLU A 122
 None
 1.39A 3w9tA-1gdhA:
0.0		 3w9tA-1gdhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 5 GLU A 143
GLY A 142
TYR A 260
GLU A 122
 None
 1.39A 3w9tC-1gdhA:
undetectable		 3w9tC-1gdhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 5 GLU A 143
GLY A 142
TYR A 260
GLU A 122
 None
 1.39A 3w9tD-1gdhA:
0.0		 3w9tD-1gdhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 5 GLU A 143
GLY A 142
TYR A 260
GLU A 122
 None
 1.40A 3w9tG-1gdhA:
0.0		 3w9tG-1gdhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 8 LEU A 197
SER A 196
THR A 192
ASP A 174
 None
 0.99A 4drjB-1gdhA:
undetectable		 4drjB-1gdhA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		5 / 8 LEU A 258
LEU A 253
LEU A 279
LYS A 227
ILE A 226
 None
 1.50A 4klaA-1gdhA:
3.6		 4klaA-1gdhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 8 LEU A 209
VAL A 244
LEU A 200
LEU A 197
 None
 0.96A 4l1xA-1gdhA:
1.6		 4l1xA-1gdhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 5 GLY A 262
LEU A 162
LEU A 145
LEU A 229
 None
 0.83A 4o8fA-1gdhA:
0.0		 4o8fA-1gdhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		5 / 12 ALA A  14
LEU A  11
GLU A 107
ALA A 104
ALA A 295
 None
 1.21A 4pclA-1gdhA:
7.5		 4pclA-1gdhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 4 ASN A 210
VAL A 236
THR A 105
ILE A 108
 None
 1.40A 4retA-1gdhA:
0.0		 4retA-1gdhA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 4 ASN A 210
VAL A 236
THR A 105
ILE A 108
 None
 1.40A 4retC-1gdhA:
3.0		 4retC-1gdhA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1gdh D-GLYCERATE
DEHYDROGENASE
(Hyphomicrobium
methylovorum) 		4 / 6 PRO A 230
ALA A 163
LEU A 162
TYR A 153
 None
 1.08A 5igiA-1gdhA:
undetectable		 5igiA-1gdhA:
22.03