SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ge7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 11 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 126
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.13A 1cmaA-1ge7A:
undetectable
1cmaB-1ge7A:
undetectable		 1cmaA-1ge7A:
20.00
1cmaB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 11 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 127
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.15A 1cmaA-1ge7A:
undetectable
1cmaB-1ge7A:
undetectable		 1cmaA-1ge7A:
20.00
1cmaB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.10A 1mj2A-1ge7A:
undetectable
1mj2B-1ge7A:
undetectable		 1mj2A-1ge7A:
20.00
1mj2B-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 127
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.13A 1mj2A-1ge7A:
undetectable
1mj2B-1ge7A:
undetectable		 1mj2A-1ge7A:
20.00
1mj2B-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.10A 1mj2C-1ge7A:
undetectable
1mj2D-1ge7A:
undetectable		 1mj2C-1ge7A:
20.00
1mj2D-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 9 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 126
 ZN  A 200 ( 4.2A)
None
None
None
None
 0.98A 1mjlA-1ge7A:
undetectable
1mjlB-1ge7A:
undetectable		 1mjlA-1ge7A:
20.00
1mjlB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 9 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 127
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.09A 1mjlA-1ge7A:
undetectable
1mjlB-1ge7A:
undetectable		 1mjlA-1ge7A:
20.00
1mjlB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.10A 1mjoC-1ge7A:
undetectable
1mjoD-1ge7A:
undetectable		 1mjoC-1ge7A:
20.00
1mjoD-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 127
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.12A 1mjoC-1ge7A:
undetectable
1mjoD-1ge7A:
undetectable		 1mjoC-1ge7A:
20.00
1mjoD-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 11 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 126
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.04A 1mjqA-1ge7A:
undetectable
1mjqB-1ge7A:
undetectable		 1mjqA-1ge7A:
20.00
1mjqB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 11 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.05A 1mjqA-1ge7A:
undetectable
1mjqB-1ge7A:
undetectable		 1mjqA-1ge7A:
20.00
1mjqB-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.06A 1mjqC-1ge7A:
undetectable
1mjqD-1ge7A:
undetectable		 1mjqC-1ge7A:
20.00
1mjqD-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 10 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.05A 1mjqG-1ge7A:
undetectable
1mjqH-1ge7A:
undetectable		 1mjqG-1ge7A:
20.00
1mjqH-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 11 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 126
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.10A 1mjqI-1ge7A:
undetectable
1mjqJ-1ge7A:
undetectable		 1mjqI-1ge7A:
20.00
1mjqJ-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 11 GLU A 118
GLU A 157
HIS A 156
HIS A  59
GLY A 127
 ZN  A 200 ( 4.2A)
None
None
None
None
 1.11A 1mjqI-1ge7A:
undetectable
1mjqJ-1ge7A:
undetectable		 1mjqI-1ge7A:
20.00
1mjqJ-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 12 HIS A  59
GLY A 126
GLU A 118
GLU A 157
HIS A 156
 None
None
ZN  A 200 ( 4.2A)
None
None
 1.06A 1mjqI-1ge7A:
undetectable
1mjqJ-1ge7A:
undetectable		 1mjqI-1ge7A:
20.00
1mjqJ-1ge7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		5 / 10 THR A  82
THR A 114
HIS A 117
GLU A 118
HIS A 121
 None
None
ZN  A 200 (-3.3A)
ZN  A 200 ( 4.2A)
ZN  A 200 (-3.2A)
 0.63A 1r55A-1ge7A:
3.7		 1r55A-1ge7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		3 / 3 ASP A 130
TYR A 133
GLU A 157
 ZN  A 200 (-1.9A)
None
None
 0.82A 1vm1A-1ge7A:
0.0		 1vm1A-1ge7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		4 / 8 THR A 114
HIS A 117
GLU A 118
HIS A 121
 None
ZN  A 200 (-3.3A)
ZN  A 200 ( 4.2A)
ZN  A 200 (-3.2A)
 0.36A 2jihB-1ge7A:
2.3		 2jihB-1ge7A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		4 / 7 GLU A 157
ALA A 137
ASN A 152
ALA A 138
 None
 1.11A 2zgwA-1ge7A:
0.0		 2zgwA-1ge7A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		4 / 6 GLU A 157
ALA A 137
ASN A 152
ALA A 138
 None
 1.15A 2zgwB-1ge7A:
0.0		 2zgwB-1ge7A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		4 / 6 PHE A 159
LEU A  31
HIS A  34
THR A  38
 None
 1.30A 4paeA-1ge7A:
0.0		 4paeA-1ge7A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		4 / 6 PHE A 159
TYR A  60
LEU A  31
THR A  38
 None
 1.27A 4paeA-1ge7A:
0.0		 4paeA-1ge7A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1ge7 PEPTIDYL-LYS
METALLOENDOPEPTIDASE
(Grifola
frondosa) 		3 / 3 ALA A  84
GLN A 111
THR A 114
 None
 0.66A 5n0oA-1ge7A:
0.0		 5n0oA-1ge7A:
16.49