SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1gec GLYCYL ENDOPEPTIDASE
(Carica
papaya) 		7 / 10 GLN E  19
SER E  24
TRP E  26
PHE E  28
SER E  29
HIS E 159
ALA E 160
 None
 0.65A 1stfE-1gecE:
39.4
1stfI-1gecE:
1.0		 1stfE-1gecE:
65.28
1stfI-1gecE:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1gec GLYCYL ENDOPEPTIDASE
(Carica
papaya) 		4 / 8 LEU E 121
TYR E 207
ILE E 175
ILE E 177
 None
 0.69A 2bu8A-1gecE:
undetectable		 2bu8A-1gecE:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1gec GLYCYL ENDOPEPTIDASE
(Carica
papaya) 		3 / 3 LYS E   1
TYR E 166
PRO E   2
 None
 1.22A 2j9cC-1gecE:
0.0		 2j9cC-1gecE:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gec GLYCYL ENDOPEPTIDASE
(Carica
papaya) 		3 / 3 PHE E  28
VAL E 164
ILE E 177
 None
 0.54A 4emaA-1gecE:
0.0		 4emaA-1gecE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1gec GLYCYL ENDOPEPTIDASE
(Carica
papaya) 		4 / 6 ILE E 148
GLY E 202
ASN E 199
ILE E 193
 None
 1.00A 5j4nB-1gecE:
0.0		 5j4nB-1gecE:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gec GLYCYL ENDOPEPTIDASE
(Carica
papaya) 		5 / 8 GLY E 119
LEU E 121
VAL E 206
ILE E 125
ILE E 148
 None
 1.09A 5vkqB-1gecE:
undetectable
5vkqC-1gecE:
undetectable		 5vkqB-1gecE:
7.92
5vkqC-1gecE:
7.92