SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1geu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 TYR A   7
GLY A  13
GLY A  16
GLY A  15
ASN A 304
 None
FAD  A 451 (-3.0A)
None
FAD  A 451 (-3.5A)
None
 1.20A 1qzzA-1geuA:
2.4		 1qzzA-1geuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 285
PHE A 117
ILE A 130
ILE A   8
ILE A 298
 None
 0.97A 1r5lA-1geuA:
undetectable		 1r5lA-1geuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 135
ALA A   9
ILE A 285
LEU A 272
ILE A 298
 None
 0.99A 1rx2A-1geuA:
undetectable		 1rx2A-1geuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		4 / 8 ILE A 261
GLY A 154
ILE A 155
PRO A 143
 NAD  A 452 (-3.9A)
None
None
None
 0.62A 1sh9A-1geuA:
undetectable		 1sh9A-1geuA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  12
ALA A 138
GLY A 140
LEU A 136
LEU A 103
 FAD  A 451 ( 4.9A)
FAD  A 451 (-4.6A)
FAD  A 451 (-3.5A)
None
None
 1.06A 2nyuB-1geuA:
3.4		 2nyuB-1geuA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 8 ALA A  57
GLU A  61
LEU A 189
VAL A 170
ILE A 258
 None
 1.07A 2uxpA-1geuA:
undetectable		 2uxpA-1geuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		4 / 4 GLU A 264
ARG A 142
ASN A 267
ASP A 268
 None
 1.09A 2zq9A-1geuA:
1.5		 2zq9A-1geuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  12
GLY A  16
ILE A  95
GLY A  40
GLY A  39
 FAD  A 451 ( 4.9A)
None
None
FAD  A 451 (-3.2A)
None
 1.01A 3axzA-1geuA:
0.0		 3axzA-1geuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 226
ILE A 261
GLY A 174
ILE A 178
GLY A 262
 None
NAD  A 452 (-3.9A)
NAD  A 452 (-3.2A)
NAD  A 452 (-3.3A)
NAD  A 452 (-3.3A)
 0.91A 3bwcA-1geuA:
2.9		 3bwcA-1geuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 226
ILE A 261
GLY A 174
ILE A 178
GLY A 262
 None
NAD  A 452 (-3.9A)
NAD  A 452 (-3.2A)
NAD  A 452 (-3.3A)
NAD  A 452 (-3.3A)
 0.95A 3bwcB-1geuA:
2.9		 3bwcB-1geuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		6 / 12 GLY A  39
SER A  14
GLY A  15
GLY A  16
ILE A  92
LYS A  36
 None
FAD  A 451 (-3.1A)
FAD  A 451 (-3.5A)
None
None
FAD  A 451 (-2.6A)
 1.27A 3douA-1geuA:
undetectable		 3douA-1geuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		4 / 8 ILE A 270
ASN A 280
VAL A 277
GLY A 276
 FAD  A 451 (-4.4A)
None
None
None
 0.95A 3em0B-1geuA:
0.0		 3em0B-1geuA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 193
GLY A 184
ILE A 258
SER A 157
VAL A 343
 None
None
None
FAD  A 451 ( 3.9A)
NAD  A 452 ( 4.7A)
 1.07A 3frqB-1geuA:
undetectable		 3frqB-1geuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 PRO A 347
THR A 213
ILE A 210
MET A 209
SER A 374
 None
 1.42A 3g4lD-1geuA:
undetectable		 3g4lD-1geuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 285
THR A 279
VAL A 277
ASN A 269
ILE A 270
 None
None
None
None
FAD  A 451 (-4.4A)
 1.12A 3kpdB-1geuA:
undetectable		 3kpdB-1geuA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		3 / 3 GLN A 387
PHE A 410
TYR A  66
 None
 0.96A 3ucjB-1geuA:
undetectable		 3ucjB-1geuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		3 / 3 GLN A 387
PHE A 410
TYR A  66
 None
 0.95A 3ucjA-1geuA:
undetectable		 3ucjA-1geuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 135
ALA A   9
ILE A 285
LEU A 272
ILE A 298
 None
 1.03A 4kjkA-1geuA:
undetectable		 4kjkA-1geuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 135
ALA A   9
ILE A 285
LEU A 272
ILE A 298
 None
 1.00A 4kjlA-1geuA:
undetectable		 4kjlA-1geuA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ARG A 320
GLU A 332
GLU A 323
LYS A 329
TYR A  26
 None
 1.24A 4mwxA-1geuA:
undetectable		 4mwxA-1geuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 334
GLY A  15
ALA A 317
ASN A 304
GLY A 140
 None
FAD  A 451 (-3.5A)
None
None
FAD  A 451 (-3.5A)
 1.08A 4n09A-1geuA:
4.3		 4n09A-1geuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 334
GLY A  16
GLY A  15
ALA A 317
GLY A 140
 None
None
FAD  A 451 (-3.5A)
None
FAD  A 451 (-3.5A)
 1.01A 4n09B-1geuA:
4.8		 4n09B-1geuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		6 / 12 LEU A 334
GLY A  16
GLY A  15
ALA A 317
ASN A 304
GLY A 140
 None
None
FAD  A 451 (-3.5A)
None
None
FAD  A 451 (-3.5A)
 1.02A 4n09D-1geuA:
4.9		 4n09D-1geuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ALA A 132
GLY A 297
ILE A 285
THR A 279
LEU A 272
 None
 1.02A 4n48B-1geuA:
undetectable		 4n48B-1geuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 135
ALA A   9
ILE A 285
LEU A 272
ILE A 298
 None
 1.03A 4pthA-1geuA:
undetectable		 4pthA-1geuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 8 ASN A 228
VAL A 215
LEU A 225
PHE A 196
GLY A 174
 None
None
None
None
NAD  A 452 (-3.2A)
 1.43A 4r3aA-1geuA:
undetectable		 4r3aA-1geuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  12
GLY A  16
ILE A  95
GLY A  40
GLY A  39
 FAD  A 451 ( 4.9A)
None
None
FAD  A 451 (-3.2A)
None
 1.03A 4yvgA-1geuA:
undetectable		 4yvgA-1geuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  11
GLY A  13
SER A  14
GLY A  15
LYS A 112
 FAD  A 451 (-3.4A)
FAD  A 451 (-3.0A)
FAD  A 451 (-3.1A)
FAD  A 451 (-3.5A)
None
 0.92A 5c0oH-1geuA:
3.2		 5c0oH-1geuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		4 / 4 ASP A 158
SER A 157
ASP A 156
HIS A 145
 None
FAD  A 451 ( 3.9A)
None
None
 0.92A 5wyqB-1geuA:
0.5		 5wyqB-1geuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		4 / 8 THR A 380
THR A 383
TRP A  54
ALA A 220
 None
 1.03A 5x2tI-1geuA:
undetectable
5x2tJ-1geuA:
undetectable
5x2tK-1geuA:
undetectable
5x2tL-1geuA:
undetectable		 5x2tI-1geuA:
15.33
5x2tJ-1geuA:
18.14
5x2tK-1geuA:
15.33
5x2tL-1geuA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1geu GLUTATHIONE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 135
ALA A   9
ILE A 285
LEU A 272
ILE A 298
 None
 1.04A 7dfrA-1geuA:
undetectable		 7dfrA-1geuA:
17.33