SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  34
ILE A 300
ILE A 280
ILE A 348
LEU A 321
 None
 0.97A 2o4nA-1geyA:
undetectable		 2o4nA-1geyA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 SER A 141
ASP A 167
ASP A 136
 None
 0.66A 2plwA-1geyA:
2.6		 2plwA-1geyA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A 187
TYR A 299
ILE A 272
SER A 295
 PPE  A 413 (-4.4A)
None
None
None
 1.11A 2xz5B-1geyA:
0.0
2xz5E-1geyA:
0.0		 2xz5B-1geyA:
20.00
2xz5E-1geyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A 272
SER A 295
TYR A 187
TYR A 299
 None
None
PPE  A 413 (-4.4A)
None
 1.09A 2xz5D-1geyA:
0.0
2xz5E-1geyA:
0.0		 2xz5D-1geyA:
20.00
2xz5E-1geyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		6 / 12 ILE A 180
LEU A 174
ASP A 145
VAL A 149
LEU A 104
VAL A 127
 None
 1.35A 2yqzB-1geyA:
3.3		 2yqzB-1geyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ALA A  84
TYR A 113
GLY A  87
ILE A  88
 PPE  A 413 (-3.7A)
None
None
None
 0.88A 2zm9A-1geyA:
0.0		 2zm9A-1geyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 PRO A 328
LEU A 330
ARG A 335
 None
None
PPE  A 413 (-3.3A)
 0.84A 3aqiA-1geyA:
undetectable		 3aqiA-1geyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 SER A 116
VAL A 149
TYR A 151
ILE A  88
 None
 1.16A 3bu1A-1geyA:
0.0		 3bu1A-1geyA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 PRO A 165
PHE A 168
ILE A 208
ALA A 194
SER A 195
 None
 1.29A 4a83A-1geyA:
0.6		 4a83A-1geyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 PHE A  45
ALA A 254
LEU A 212
LEU A 221
 None
 0.71A 4ejgB-1geyA:
0.0		 4ejgB-1geyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 PHE A  45
ALA A 254
LEU A 212
LEU A 221
 None
 0.70A 4ejgC-1geyA:
0.0		 4ejgC-1geyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  79
GLU A  86
GLY A  83
CYH A 223
ALA A  84
 None
None
PPE  A 413 (-3.4A)
None
PPE  A 413 (-3.7A)
 1.25A 4pclB-1geyA:
3.6		 4pclB-1geyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 ALA A 186
THR A 226
GLY A 224
GLY A  83
ALA A  84
 PPE  A 413 (-3.6A)
None
PPE  A 413 ( 4.9A)
PPE  A 413 (-3.4A)
PPE  A 413 (-3.7A)
 0.96A 4qvpK-1geyA:
undetectable
4qvpL-1geyA:
undetectable		 4qvpK-1geyA:
19.50
4qvpL-1geyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 ALA A 186
THR A 226
GLY A 224
GLY A  83
ALA A  84
 PPE  A 413 (-3.6A)
None
PPE  A 413 ( 4.9A)
PPE  A 413 (-3.4A)
PPE  A 413 (-3.7A)
 0.96A 4qvpY-1geyA:
undetectable
4qvpZ-1geyA:
undetectable		 4qvpY-1geyA:
19.50
4qvpZ-1geyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 VAL A  78
LEU A 227
VAL A  73
 None
 0.55A 4wq4A-1geyA:
undetectable		 4wq4A-1geyA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ALA A  36
ARG A  82
GLY A  83
GLU A  86
 PPE  A 413 (-3.7A)
None
PPE  A 413 (-3.4A)
None
 0.78A 5bs8A-1geyA:
1.3
5bs8C-1geyA:
1.3
5bs8D-1geyA:
1.0		 5bs8A-1geyA:
24.36
5bs8C-1geyA:
24.36
5bs8D-1geyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 ALA A  36
ARG A  82
GLY A  83
GLU A  86
 PPE  A 413 (-3.7A)
None
PPE  A 413 (-3.4A)
None
 0.90A 5btgA-1geyA:
1.3
5btgC-1geyA:
1.3
5btgD-1geyA:
undetectable		 5btgA-1geyA:
24.36
5btgC-1geyA:
24.36
5btgD-1geyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A  79
LEU A 235
LEU A 236
LEU A  91
ALA A  94
 None
 1.01A 5dqfA-1geyA:
undetectable		 5dqfA-1geyA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 VAL A 249
SER A 213
MET A 265
 None
PPE  A 413 (-2.8A)
None
 0.77A 5ikqA-1geyA:
0.0		 5ikqA-1geyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A 227
ALA A 207
LEU A 206
LEU A  91
 None
 0.86A 5vkqA-1geyA:
0.0
5vkqD-1geyA:
0.0		 5vkqA-1geyA:
11.73
5vkqD-1geyA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A  91
LEU A 227
ALA A 207
LEU A 206
 None
 0.87A 5vkqA-1geyA:
0.0
5vkqB-1geyA:
0.0		 5vkqA-1geyA:
11.73
5vkqB-1geyA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A  91
LEU A 227
ALA A 207
LEU A 206
 None
 0.88A 5vkqC-1geyA:
0.0
5vkqD-1geyA:
0.0		 5vkqC-1geyA:
11.73
5vkqD-1geyA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 303
PHE A 304
GLY A 332
 None
 0.80A 6fgdA-1geyA:
1.2		 6fgdA-1geyA:
24.32