SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 7 ARG A 167
ARG A  82
ARG A 132
ASN A  64
 None
 1.38A 1f9gA-1gfnA:
4.6		 1f9gA-1gfnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 6 ARG A 140
ASP A  97
THR A 138
ASP A 107
 None
 0.84A 2j2pE-1gfnA:
0.0
2j2pF-1gfnA:
0.0		 2j2pE-1gfnA:
19.16
2j2pF-1gfnA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 7 TYR A 124
THR A 238
LEU A 291
VAL A 292
 None
 1.05A 2zwuA-1gfnA:
undetectable		 2zwuA-1gfnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 11 THR A 276
VAL A 257
VAL A 326
LEU A 324
ILE A 318
 None
 1.43A 3elzB-1gfnA:
1.4		 3elzB-1gfnA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 7 TYR A 124
THR A 238
LEU A 291
VAL A 292
 None
 1.02A 3fwiA-1gfnA:
undetectable		 3fwiA-1gfnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 4 GLY A  59
TYR A  58
GLY A  87
ASP A  97
 None
 0.70A 3kl3A-1gfnA:
undetectable		 3kl3A-1gfnA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		3 / 3 ASN A 252
LEU A 324
PHE A 250
 None
 0.79A 4dajB-1gfnA:
0.0		 4dajB-1gfnA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 9 TYR A  22
GLY A  34
SER A 125
ARG A 167
ARG A 168
 None
 1.17A 4gcpA-1gfnA:
44.9		 4gcpA-1gfnA:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		7 / 9 TYR A  22
TYR A  32
GLY A  33
TYR A 124
SER A 125
ARG A 167
ARG A 168
 None
 0.36A 4gcpA-1gfnA:
44.9		 4gcpA-1gfnA:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 9 TYR A  22
GLY A  34
SER A 125
ARG A 167
ARG A 168
 None
 1.17A 4gcpB-1gfnA:
45.0		 4gcpB-1gfnA:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		7 / 9 TYR A  22
TYR A  32
GLY A  33
TYR A 124
SER A 125
ARG A 167
ARG A 168
 None
 0.35A 4gcpB-1gfnA:
45.0		 4gcpB-1gfnA:
98.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		3 / 3 ASP A 288
LEU A 291
VAL A 257
 None
 0.71A 4jecB-1gfnA:
undetectable		 4jecB-1gfnA:
14.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 8 LYS A  16
TYR A  40
ARG A  82
ARG A 132
 None
 0.88A 4kr4C-1gfnA:
35.6		 4kr4C-1gfnA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 10 LYS A  16
TYR A  40
ARG A  82
TYR A 102
ARG A 132
 None
 0.86A 4kr8C-1gfnA:
37.3		 4kr8C-1gfnA:
55.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		3 / 3 ASN A 252
LEU A 324
PHE A 250
 None
 0.71A 5dsgA-1gfnA:
undetectable		 5dsgA-1gfnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 12 ALA A 166
PRO A 239
PHE A 250
GLY A 206
SER A 248
 None
 1.43A 5hfjG-1gfnA:
undetectable		 5hfjG-1gfnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 10 ALA A 251
ILE A 240
GLY A 285
GLY A 206
VAL A 289
 None
 1.18A 5i6xA-1gfnA:
undetectable		 5i6xA-1gfnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		3 / 3 TYR A  90
ASP A  92
ASP A  54
 None
 0.70A 5x6yA-1gfnA:
undetectable		 5x6yA-1gfnA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 7 GLN A  60
GLY A 134
GLY A  99
VAL A 136
 None
 0.67A 6ekzA-1gfnA:
0.0		 6ekzA-1gfnA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		4 / 6 ASN A 101
TYR A 102
VAL A 136
VAL A 104
 None
 1.38A 6f32B-1gfnA:
undetectable		 6f32B-1gfnA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1gfn MATRIX PORIN OUTER
MEMBRANE PROTEIN F
(Escherichia
coli) 		5 / 10 SER A 278
TYR A 124
VAL A 130
GLY A 103
ALA A 154
 None
 1.49A 6hu9L-1gfnA:
0.0
6hu9P-1gfnA:
0.4
6hu9T-1gfnA:
0.0		 6hu9L-1gfnA:
20.68
6hu9P-1gfnA:
20.67
6hu9T-1gfnA:
12.62