SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		5 / 10 LEU A  39
LEU A  75
ALA A  62
PHE A  40
GLY A  60
 None
 1.37A 1cmcA-1gg4A:
undetectable
1cmcB-1gg4A:
undetectable		 1cmcA-1gg4A:
11.95
1cmcB-1gg4A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 7 VAL A 375
GLY A 376
ASP A 360
VAL A 358
 None
 0.52A 1p2yA-1gg4A:
0.0		 1p2yA-1gg4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 6 VAL A  41
THR A  29
ARG A  84
PHE A  87
 None
 0.95A 1s8fB-1gg4A:
1.7		 1s8fB-1gg4A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 6 LEU A 159
ILE A 157
PRO A 176
VAL A  80
 None
 1.14A 2ygoA-1gg4A:
0.0		 2ygoA-1gg4A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_1
(SPERMIDINE SYNTHASE)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 4 LEU A  65
GLN A  77
ASP A  55
ASP A  72
 None
 1.36A 3bwcA-1gg4A:
3.2		 3bwcA-1gg4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		5 / 12 PHE A  87
ALA A  92
VAL A  41
ILE A 157
THR A 170
 None
 1.17A 3dl9A-1gg4A:
0.0		 3dl9A-1gg4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 5 LEU A 300
ALA A 290
THR A 268
PHE A 248
 None
 1.02A 3vasB-1gg4A:
5.0		 3vasB-1gg4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 7 ALA A  50
ASP A  49
ILE A  79
THR A  28
 None
 0.82A 4eyrA-1gg4A:
0.0		 4eyrA-1gg4A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 6 ALA A 379
LEU A 356
VAL A 355
GLU A 405
 None
 0.99A 4g24A-1gg4A:
undetectable		 4g24A-1gg4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		5 / 11 LEU A  75
GLY A  60
PHE A  40
LEU A  65
ALA A  54
 None
 1.18A 4wnuA-1gg4A:
0.0		 4wnuA-1gg4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		5 / 10 GLY A  63
PHE A  40
ALA A  54
ASP A  55
ALA A  59
 None
 1.33A 4wnuD-1gg4A:
0.0		 4wnuD-1gg4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		3 / 3 ASN A 182
SER A 109
SER A 108
 None
 0.77A 5gsnA-1gg4A:
2.9		 5gsnA-1gg4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 105
THR A 128
TYR A 130
GLN A 124
 None
 1.14A 5hbsA-1gg4A:
0.0		 5hbsA-1gg4A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE
(Escherichia
coli) 		4 / 5 ILE A  12
LEU A  13
THR A  23
LEU A  24
 None
 0.88A 6nmpN-1gg4A:
0.0
6nmpW-1gg4A:
0.0		 6nmpN-1gg4A:
24.55
6nmpW-1gg4A:
8.61