SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ggm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 10 GLU A 188
ARG A 220
GLN A 237
GLU A 241
TYR A 287
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
None
 0.96A 1httA-1ggmA:
23.3		 1httA-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 10 GLU A 188
ARG A 220
GLN A 237
TYR A 287
GLY A 307
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
GAP  A1550 ( 4.6A)
 1.18A 1httA-1ggmA:
23.3		 1httA-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 188
ARG A 220
GLN A 237
GLU A 241
TYR A 287
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
None
 1.14A 1httB-1ggmA:
23.7		 1httB-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 188
ARG A 220
GLN A 237
TYR A 287
GLY A 307
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
GAP  A1550 ( 4.6A)
 1.26A 1httB-1ggmA:
23.7		 1httB-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 188
ARG A 220
GLN A 237
GLU A 241
TYR A 287
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
None
 1.05A 1httD-1ggmA:
23.7		 1httD-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 188
ARG A 220
GLN A 237
TYR A 287
GLY A 307
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
GAP  A1550 ( 4.6A)
 1.19A 1httD-1ggmA:
23.7		 1httD-1ggmA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 8 ARG A 431
GLY A  35
VAL A  39
GLU A  40
 None
 0.76A 1pk7B-1ggmA:
undetectable		 1pk7B-1ggmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLY A 363
GLY A 367
GLN A 214
SER A 361
ARG A 260
 GAP  A1550 (-2.7A)
None
None
GAP  A1550 ( 2.4A)
None
 1.08A 1wg8A-1ggmA:
undetectable		 1wg8A-1ggmA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 7 LEU A  45
LEU A 396
GLU A 259
ARG A  52
 None
 1.06A 2jn3A-1ggmA:
0.8		 2jn3A-1ggmA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 ILE A 240
PHE A 243
PHE A 194
ARG A 311
ILE A 193
 None
None
None
GAP  A1550 (-3.8A)
None
 1.25A 2y7kC-1ggmA:
undetectable		 2y7kC-1ggmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		7 / 7 GLU A 188
ARG A 220
GLU A 239
TYR A 287
ARG A 311
GLU A 359
SER A 361
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 2.2A)
None
GAP  A1550 (-3.8A)
GAP  A1550 ( 2.7A)
GAP  A1550 ( 2.4A)
 0.59A 2zt7A-1ggmA:
34.7		 2zt7A-1ggmA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 7 GLN A 191
GLY A 192
HIS A  79
HIS A 319
 None
 1.23A 3ai8A-1ggmA:
undetectable		 3ai8A-1ggmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		3 / 3 LEU A 316
TRP A 252
TYR A 344
 None
 0.91A 3aicF-1ggmA:
undetectable		 3aicF-1ggmA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		3 / 3 LEU A 316
TRP A 252
TYR A 344
 None
 0.98A 3aicH-1ggmA:
undetectable		 3aicH-1ggmA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		3 / 3 ARG A  57
ILE A 358
TRP A 252
 None
 1.07A 3e68A-1ggmA:
0.0		 3e68A-1ggmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 4 LEU A  41
GLY A  38
LEU A  37
GLU A  40
 None
 1.10A 3tgvB-1ggmA:
0.2		 3tgvB-1ggmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		3 / 3 TRP A 252
VAL A 257
TRP A 256
 None
 1.18A 3zq8C-1ggmA:
undetectable
3zq8D-1ggmA:
undetectable		 3zq8C-1ggmA:
5.80
3zq8D-1ggmA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 8 ARG A 220
ARG A 231
PHE A 235
ARG A 366
 GAP  A1550 ( 2.4A)
None
GAP  A1550 ( 3.5A)
GAP  A1550 ( 3.4A)
 0.73A 4k87A-1ggmA:
25.6		 4k87A-1ggmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 8 ARG A 220
ARG A 231
PHE A 235
GLY A 307
 GAP  A1550 ( 2.4A)
None
GAP  A1550 ( 3.5A)
GAP  A1550 ( 4.6A)
 0.86A 4k87A-1ggmA:
25.6		 4k87A-1ggmA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		6 / 6 GLU A 188
ARG A 220
GLU A 239
ARG A 311
GLU A 359
SER A 361
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 2.2A)
GAP  A1550 (-3.8A)
GAP  A1550 ( 2.7A)
GAP  A1550 ( 2.4A)
 0.65A 4kr3A-1ggmA:
35.5		 4kr3A-1ggmA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 9 PHE A 298
ALA A 373
ALA A 375
LEU A 369
VAL A 368
 None
 1.34A 4or0A-1ggmA:
undetectable		 4or0A-1ggmA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 6 ILE A 193
PHE A 194
ARG A 311
GLU A 188
 None
None
GAP  A1550 (-3.8A)
GAP  A1550 ( 2.6A)
 1.35A 4zzcB-1ggmA:
0.0
4zzcC-1ggmA:
0.0		 4zzcB-1ggmA:
19.68
4zzcC-1ggmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 188
ARG A 220
GLN A 237
GLU A 241
TYR A 287
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
None
 1.02A 5e3iA-1ggmA:
21.9		 5e3iA-1ggmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 188
ARG A 220
GLN A 237
TYR A 287
GLY A 307
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
GAP  A1550 ( 4.6A)
 1.12A 5e3iA-1ggmA:
21.9		 5e3iA-1ggmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 11 GLU A 188
ARG A 220
GLN A 237
GLU A 241
TYR A 287
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
None
 1.01A 5e3iB-1ggmA:
21.5		 5e3iB-1ggmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 11 GLU A 188
ARG A 220
GLN A 237
TYR A 287
GLY A 307
 GAP  A1550 ( 2.6A)
GAP  A1550 ( 2.4A)
GAP  A1550 ( 3.5A)
None
GAP  A1550 ( 4.6A)
 1.11A 5e3iB-1ggmA:
21.5		 5e3iB-1ggmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 4 ASP A 315
GLY A 317
ASP A 313
ASP A 249
 None
 1.11A 5e72A-1ggmA:
undetectable		 5e72A-1ggmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 8 VAL A 354
ILE A 328
ALA A 330
THR A 312
VAL A 357
 None
 1.49A 5l94A-1ggmA:
undetectable		 5l94A-1ggmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 8 ASN A 227
PHE A 228
ARG A 366
GLY A 367
 None
None
GAP  A1550 ( 3.4A)
None
 1.00A 5nzxA-1ggmA:
1.6		 5nzxA-1ggmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 11 LEU A 392
PRO A 398
GLU A 449
LEU A 371
ALA A 375
 None
 1.12A 5o96A-1ggmA:
2.5
5o96B-1ggmA:
2.4		 5o96A-1ggmA:
19.77
5o96B-1ggmA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A 239
GLY A 216
VAL A 200
GLY A 192
ILE A 193
 GAP  A1550 ( 2.2A)
None
None
None
None
 1.03A 5vopB-1ggmA:
undetectable		 5vopB-1ggmA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		3 / 3 THR A 462
THR A 476
ARG A 489
 None
 1.03A 5wm2A-1ggmA:
undetectable		 5wm2A-1ggmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		6 / 10 ARG A 220
GLU A 222
PHE A 235
GLU A 304
GLY A 363
ARG A 366
 GAP  A1550 ( 2.4A)
GAP  A1550 (-3.2A)
GAP  A1550 ( 3.5A)
GAP  A1550 ( 3.8A)
GAP  A1550 (-2.7A)
GAP  A1550 ( 3.4A)
 0.64A 6bniA-1ggmA:
13.7		 6bniA-1ggmA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		6 / 10 ARG A 220
GLU A 222
PHE A 235
GLU A 304
GLY A 363
ARG A 366
 GAP  A1550 ( 2.4A)
GAP  A1550 (-3.2A)
GAP  A1550 ( 3.5A)
GAP  A1550 ( 3.8A)
GAP  A1550 (-2.7A)
GAP  A1550 ( 3.4A)
 0.62A 6bniB-1ggmA:
14.5		 6bniB-1ggmA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 6 SER A 284
ASP A 293
GLN A 278
GLU A 304
 None
None
None
GAP  A1550 ( 3.8A)
 1.00A 6djzA-1ggmA:
0.0		 6djzA-1ggmA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ggm GLYCINE--TRNA LIGASE
(Thermus
thermophilus) 		4 / 6 ASP A 293
GLN A 278
VAL A 292
GLU A 304
 None
None
None
GAP  A1550 ( 3.8A)
 1.20A 6djzB-1ggmA:
0.0		 6djzB-1ggmA:
18.78