SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 VAL B 450
GLY B 449
LEU B 491
PHE B 535
VAL B 520
 None
 1.11A 1fduA-1gh6B:
undetectable		 1fduA-1gh6B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 11 LEU B 486
TYR B 453
VAL B 531
LEU B 400
LEU B 461
 None
 1.28A 1mrqA-1gh6B:
undetectable		 1mrqA-1gh6B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1gh6 LARGE T ANTIGEN
RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Macaca
mulatta
polyomavirus
1;
Homo
sapiens) 		4 / 7 TYR B 709
THR A  81
GLU A 101
SER A 106
 None
 1.21A 1tv8A-1gh6B:
undetectable		 1tv8A-1gh6B:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 LYS B 530
PHE B 526
LEU B 572
ASP B 479
 None
 1.12A 2bxkA-1gh6B:
1.0		 2bxkA-1gh6B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 416
ILE B 415
PRO B 396
VAL B 439
 None
 1.14A 2ygoA-1gh6B:
undetectable		 2ygoA-1gh6B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 9 LEU B 561
GLU B 737
TYR B 749
LEU B 564
ASP B 697
 None
 1.21A 3hthB-1gh6B:
0.0		 3hthB-1gh6B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 6 HIS B 549
LEU B 486
ILE B 517
LEU B 389
 None
 0.95A 3kk6A-1gh6B:
undetectable		 3kk6A-1gh6B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 10 ALA B 734
ILE B 680
LEU B 665
ILE B 753
THR B 738
 None
 1.09A 3prsA-1gh6B:
undetectable		 3prsA-1gh6B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 7 VAL B 456
PHE B 535
VAL B 493
ILE B 388
 None
 0.98A 3zjqA-1gh6B:
0.0		 3zjqA-1gh6B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 7 VAL B 456
PHE B 535
VAL B 493
ILE B 388
 None
 0.98A 3zjqB-1gh6B:
0.0		 3zjqB-1gh6B:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 ILE B 517
LEU B 491
ILE B 425
GLY B 442
 None
 0.80A 4hb8A-1gh6B:
undetectable		 4hb8A-1gh6B:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 547
PHE B 535
THR B 497
LEU B 385
LEU B 452
 None
 1.07A 4km2A-1gh6B:
undetectable		 4km2A-1gh6B:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 5 MET B 695
LEU B 688
ARG B 661
SER B 567
 None
 0.97A 4kmmB-1gh6B:
undetectable		 4kmmB-1gh6B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		4 / 8 LEU B 486
TYR B 453
VAL B 531
LEU B 461
 None
 1.02A 4l1xA-1gh6B:
undetectable		 4l1xA-1gh6B:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1gh6 LARGE T ANTIGEN
(Macaca
mulatta
polyomavirus
1) 		3 / 3 SER A  10
MET A  14
ASP A  64
 None
 0.91A 4mm4B-1gh6A:
undetectable		 4mm4B-1gh6A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		3 / 3 SER B 646
SER B 583
PHE B 526
 None
 0.92A 5mugA-1gh6B:
undetectable		 5mugA-1gh6B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 7 ILE B 401
LEU B 400
MET B 457
LEU B 461
PRO B 411
 None
 1.40A 5u4sA-1gh6B:
undetectable		 5u4sA-1gh6B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 12 PHE B 426
ILE B 532
PHE B 535
ALA B 496
GLY B 449
 None
 1.07A 5veuB-1gh6B:
0.8		 5veuB-1gh6B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens) 		5 / 10 VAL B 493
THR B 497
PHE B 535
ILE B 547
THR B 543
 None
 1.41A 6d9hR-1gh6B:
undetectable		 6d9hR-1gh6B:
14.33