SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ghs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 7 HIS A 257
LEU A 205
SER A 204
ASP A 207
 None
 1.16A 1ismB-1ghsA:
undetectable		 1ismB-1ghsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 7 LEU A 205
SER A 204
ASP A 207
PHE A 130
 None
 1.28A 1ismB-1ghsA:
undetectable		 1ismB-1ghsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 4 SER A 181
ILE A 180
VAL A 193
THR A 262
 None
 1.19A 1u70A-1ghsA:
0.2		 1u70A-1ghsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 9 GLY A  37
ALA A  39
SER A  41
LEU A  40
LEU A  50
 None
 1.45A 1y7iA-1ghsA:
undetectable		 1y7iA-1ghsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 6 TYR A  22
GLY A 233
PHE A 274
SER A 232
 None
 1.23A 2a3cB-1ghsA:
4.7		 2a3cB-1ghsA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 9 LEU A  43
PRO A  13
VAL A   7
GLY A   6
MET A 276
 None
 1.35A 2po7A-1ghsA:
1.1		 2po7A-1ghsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 9 LEU A  43
PRO A  13
VAL A   7
GLY A   6
MET A 276
 None
 1.33A 2po7B-1ghsA:
0.0		 2po7B-1ghsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 8 MET A  30
LEU A  50
ARG A  15
VAL A   7
 None
 1.16A 2qd2A-1ghsA:
undetectable		 2qd2A-1ghsA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 8 ALA A  69
ALA A 106
SER A 102
ALA A  64
 None
 0.80A 2vh3B-1ghsA:
undetectable		 2vh3B-1ghsA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 12 LEU A 110
ASN A  68
LEU A  52
ILE A  89
LEU A 119
 None
 1.26A 3a50E-1ghsA:
undetectable		 3a50E-1ghsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		3 / 3 GLY A  29
GLY A  47
GLY A  49
 None
 0.32A 3bogC-1ghsA:
undetectable		 3bogC-1ghsA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 8 LEU A 254
ALA A 268
LEU A 269
ILE A 304
 None
 0.84A 3cldB-1ghsA:
0.0		 3cldB-1ghsA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		6 / 12 ILE A 103
GLY A  92
VAL A  95
ILE A 128
ALA A  91
VAL A 152
 None
 1.41A 3fpjA-1ghsA:
undetectable		 3fpjA-1ghsA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 10 PHE A 187
HIS A 257
SER A 232
TYR A 250
VAL A 210
 None
 1.47A 3u9fD-1ghsA:
0.0
3u9fF-1ghsA:
0.0		 3u9fD-1ghsA:
21.97
3u9fF-1ghsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 12 SER A 232
TYR A 250
VAL A 210
PHE A 187
HIS A 257
 None
 1.44A 3u9fH-1ghsA:
0.0
3u9fI-1ghsA:
0.0		 3u9fH-1ghsA:
21.97
3u9fI-1ghsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 11 PHE A 187
HIS A 257
SER A 232
TYR A 250
VAL A 210
 None
 1.42A 3u9fM-1ghsA:
0.0
3u9fO-1ghsA:
0.0		 3u9fM-1ghsA:
21.97
3u9fO-1ghsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 9 ALA A 247
TYR A 250
GLY A 253
ILE A 255
ILE A 273
 None
 1.08A 4eatB-1ghsA:
undetectable		 4eatB-1ghsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 12 GLY A  92
ASN A  93
ILE A 103
TYR A 148
LEU A 156
 None
 1.33A 4kotA-1ghsA:
0.0		 4kotA-1ghsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 12 LEU A  40
GLY A   6
ALA A  39
PHE A  34
GLY A   9
 None
 1.21A 4n09A-1ghsA:
2.2		 4n09A-1ghsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 12 ALA A  99
GLY A  98
GLY A  97
ILE A 103
ASN A  56
 None
 1.06A 4obwB-1ghsA:
undetectable		 4obwB-1ghsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		4 / 6 ILE A 304
GLY A  29
ASN A  28
ILE A 273
 None
 1.00A 5j4nB-1ghsA:
0.0		 5j4nB-1ghsA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 9 ILE A  62
ALA A  60
ILE A 103
PRO A 105
ALA A  91
 None
 0.90A 5mvmA-1ghsA:
0.0
5mvmE-1ghsA:
0.0		 5mvmA-1ghsA:
15.83
5mvmE-1ghsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 10 ILE A 103
PRO A 105
ALA A  91
ILE A  62
ALA A  60
 None
 0.89A 5mvmD-1ghsA:
0.0
5mvmE-1ghsA:
undetectable		 5mvmD-1ghsA:
15.83
5mvmE-1ghsA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		3 / 3 ALA A 212
VAL A 193
TYR A 202
 None
 0.69A 5zmqH-1ghsA:
0.0		 5zmqH-1ghsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		3 / 3 TYR A 214
ALA A 153
LEU A 156
 None
 0.69A 6ag0C-1ghsA:
5.4		 6ag0C-1ghsA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1ghs 1,3-BETA-GLUCANASE
(Hordeum
vulgare) 		5 / 11 ALA A 268
LEU A 269
VAL A 258
VAL A 229
ILE A 273
 None
 1.27A 6h1lB-1ghsA:
0.0		 6h1lB-1ghsA:
20.77