SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 8 LEU A 247
ILE A 201
ILE A 283
ILE A 281
 None
 0.77A 2bu8A-1gjvA:
17.1		 2bu8A-1gjvA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 8 TYR A  99
HIS A 132
ARG A 167
ILE A 170
 None
 0.74A 2bu8A-1gjvA:
17.1		 2bu8A-1gjvA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		5 / 12 ILE A 201
ILE A 283
ALA A 250
THR A 254
ALA A 219
 None
None
AGS  A1383 ( 4.6A)
None
None
 1.18A 2j0dA-1gjvA:
0.6		 2j0dA-1gjvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 340
PRO A 341
ARG A 252
 AGS  A1383 (-3.9A)
K  A1380 ( 4.6A)
None
 0.49A 2qd5A-1gjvA:
undetectable		 2qd5A-1gjvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 247
MET A 251
MET A 299
 None
 0.65A 2vavF-1gjvA:
undetectable		 2vavF-1gjvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 8 LEU A 239
LEU A 243
ALA A 347
LEU A 354
 None
 0.75A 2vcvF-1gjvA:
undetectable		 2vcvF-1gjvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		5 / 12 VAL A 136
LEU A 160
THR A 163
VAL A  95
TYR A  99
 None
 1.27A 3mbhC-1gjvA:
undetectable		 3mbhC-1gjvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		5 / 12 VAL A 136
LEU A 160
THR A 163
VAL A  95
TYR A  99
 None
 1.28A 3mbhE-1gjvA:
undetectable		 3mbhE-1gjvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		5 / 10 ILE A 290
LEU A 295
THR A 364
GLY A 363
GLY A 361
 AGS  A1383 ( 4.5A)
None
AGS  A1383 (-4.1A)
None
None
 1.25A 4bwlC-1gjvA:
undetectable		 4bwlC-1gjvA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 6 ILE A 200
PRO A 236
PHE A 234
PHE A 232
 None
 1.13A 4fgkA-1gjvA:
undetectable		 4fgkA-1gjvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 7 ARG A 231
LEU A 195
ILE A 272
LEU A 279
 None
 0.98A 5te8C-1gjvA:
0.0		 5te8C-1gjvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE
(Rattus
norvegicus) 		4 / 5 PHE A 336
PHE A 338
LEU A 160
PHE A 159
 AGS  A1383 (-4.1A)
None
None
None
 1.32A 5wauc-1gjvA:
1.4
5wauj-1gjvA:
0.3		 5wauc-1gjvA:
18.80
5wauj-1gjvA:
10.66