SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 HIS A 270
LEU A 282
SER A 458
LEU A 461
 None
 1.10A 1a4lB-1gk2A:
undetectable		 1a4lB-1gk2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 4 HIS A 270
LEU A 282
LEU A 358
LEU A 371
 None
 1.25A 1a4lD-1gk2A:
undetectable		 1a4lD-1gk2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 8 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
 None
 1.04A 1aq7A-1gk2A:
undetectable		 1aq7A-1gk2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 ALA A 204
LEU A 341
LEU A 303
ALA A 299
 None
 0.80A 1e7cA-1gk2A:
2.1		 1e7cA-1gk2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 9 GLY A 329
HIS A 330
ALA A 420
THR A 197
ALA A 335
 None
 1.49A 1gtnQ-1gk2A:
undetectable
1gtnR-1gk2A:
undetectable		 1gtnQ-1gk2A:
10.18
1gtnR-1gk2A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 11 ALA A 202
VAL A 155
MET A 100
LEU A 125
ARG A 163
 None
 1.45A 1kt6A-1gk2A:
undetectable		 1kt6A-1gk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		3 / 3 ASP A 145
LEU A 149
HIS A  19
 None
 0.78A 1qknA-1gk2A:
1.6		 1qknA-1gk2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 6 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
 None
 1.09A 1tnlA-1gk2A:
undetectable		 1tnlA-1gk2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 LEU A 341
ALA A 204
LEU A 208
THR A 201
 None
 1.24A 1tyrA-1gk2A:
undetectable		 1tyrA-1gk2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 12 ALA A 299
ALA A 300
LEU A 341
ALA A 337
LEU A 509
 None
 1.01A 2aclA-1gk2A:
undetectable
2aclE-1gk2A:
undetectable		 2aclA-1gk2A:
17.67
2aclE-1gk2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 LEU A 293
LEU A 501
ILE A 219
ALA A 254
 None
 0.68A 2i2zA-1gk2A:
undetectable		 2i2zA-1gk2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 6 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
 None
 1.08A 2otvA-1gk2A:
undetectable		 2otvA-1gk2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 ALA A 238
ASP A 237
GLU A 242
ARG A 247
 None
 1.44A 2ouzA-1gk2A:
0.2		 2ouzA-1gk2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 11 LEU A  25
LEU A   5
ILE A 104
ALA A  31
ASP A 120
 None
 1.17A 2q72A-1gk2A:
0.1		 2q72A-1gk2A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 11 LEU A  25
LEU A   5
ILE A 104
ALA A  31
ASP A 120
 None
 1.16A 2qjuA-1gk2A:
0.0		 2qjuA-1gk2A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 ILE A 345
LEU A 506
LEU A 208
GLY A 207
 None
 0.93A 2qqdB-1gk2A:
0.0
2qqdC-1gk2A:
0.0		 2qqdB-1gk2A:
12.15
2qqdC-1gk2A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 8 ASP A 145
SER A 200
VAL A 334
GLY A 329
GLY A 141
 None
 1.04A 2vinA-1gk2A:
undetectable		 2vinA-1gk2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 LEU A 492
ARG A 435
GLY A 436
ALA A 439
 None
 0.86A 2xfsA-1gk2A:
undetectable		 2xfsA-1gk2A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 LEU A 492
ARG A 435
GLY A 436
ALA A 439
 None
 0.85A 2xh9A-1gk2A:
0.0		 2xh9A-1gk2A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 12 LEU A 455
LEU A 451
GLY A 448
GLN A 447
THR A 457
 None
 1.16A 2yhdA-1gk2A:
undetectable		 2yhdA-1gk2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 12 LEU A 146
SER A 143
SER A 410
LEU A  75
LEU A 185
 None
SO4  A1511 (-3.2A)
None
None
None
 1.09A 2zlcA-1gk2A:
0.0		 2zlcA-1gk2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		3 / 3 LEU A 185
VAL A  42
ARG A 115
 None
 0.90A 3b0wB-1gk2A:
0.0		 3b0wB-1gk2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 LEU A 154
ALA A 171
LEU A 157
THR A 172
 None
 1.04A 3cfqA-1gk2A:
undetectable		 3cfqA-1gk2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 12 LEU A 449
GLY A 223
GLY A 222
LEU A 351
ASP A 278
 None
 1.20A 3i5uB-1gk2A:
undetectable		 3i5uB-1gk2A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 10 LEU A  27
ILE A  35
SER A 112
SER A 106
GLY A 110
 None
 1.30A 3ijxB-1gk2A:
undetectable
3ijxD-1gk2A:
undetectable		 3ijxB-1gk2A:
19.77
3ijxD-1gk2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 10 PHE A 370
VAL A 372
GLY A 375
ASN A 378
GLY A 380
 None
 1.24A 3km6A-1gk2A:
undetectable		 3km6A-1gk2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 9 PHE A 370
VAL A 372
GLY A 375
ASN A 378
GLY A 380
 None
 1.20A 3kmoA-1gk2A:
0.0		 3kmoA-1gk2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 12 LEU A 501
THR A 252
LEU A 296
LEU A 293
GLY A 248
 None
 1.38A 3n58A-1gk2A:
undetectable		 3n58A-1gk2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 ASP A 145
SER A 200
VAL A 334
GLY A 141
 None
 1.04A 3rxhA-1gk2A:
undetectable		 3rxhA-1gk2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 LEU A 341
ALA A 204
LEU A 208
THR A 201
 None
 1.23A 4d7bB-1gk2A:
undetectable		 4d7bB-1gk2A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 ASN A 328
SER A 311
LEU A 315
ARG A 109
 None
 1.22A 4ijiF-1gk2A:
1.5		 4ijiF-1gk2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 ASP A 145
SER A 139
ALA A 420
SER A 418
 None
 0.96A 4lv9A-1gk2A:
0.0
4lv9B-1gk2A:
0.0		 4lv9A-1gk2A:
21.10
4lv9B-1gk2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 7 ASP A 145
SER A 139
ALA A 420
SER A 418
 None
 0.97A 4lv9A-1gk2A:
undetectable
4lv9B-1gk2A:
undetectable		 4lv9A-1gk2A:
21.10
4lv9B-1gk2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 GLY A 349
SER A 350
ALA A 392
GLU A 353
 None
 0.97A 4m93B-1gk2A:
undetectable
4m93C-1gk2A:
undetectable		 4m93B-1gk2A:
17.15
4m93C-1gk2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 ALA A 204
ALA A 337
ALA A 331
SER A 418
 None
 0.76A 4twdF-1gk2A:
0.0
4twdG-1gk2A:
0.1
4twdH-1gk2A:
0.8
4twdI-1gk2A:
0.0
4twdJ-1gk2A:
0.0		 4twdF-1gk2A:
20.48
4twdG-1gk2A:
20.48
4twdH-1gk2A:
20.48
4twdI-1gk2A:
20.48
4twdJ-1gk2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 8 ALA A 331
SER A 418
ALA A 204
ALA A 337
 None
 0.76A 4twdF-1gk2A:
0.0
4twdG-1gk2A:
0.1
4twdH-1gk2A:
0.8
4twdI-1gk2A:
0.0
4twdJ-1gk2A:
0.0		 4twdF-1gk2A:
20.48
4twdG-1gk2A:
20.48
4twdH-1gk2A:
20.48
4twdI-1gk2A:
20.48
4twdJ-1gk2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 11 LEU A 451
LEU A 443
GLN A 447
LEU A 367
ALA A 228
 None
 1.18A 4wnuA-1gk2A:
0.4		 4wnuA-1gk2A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 11 ASP A 312
ALA A 192
TYR A  53
GLY A 144
GLY A 327
 None
 1.23A 4xp4A-1gk2A:
0.0		 4xp4A-1gk2A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 9 ARG A 247
LEU A 293
LEU A 501
ILE A 219
ALA A 254
 None
 0.80A 4z69A-1gk2A:
2.4		 4z69A-1gk2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 SER A 112
GLY A 144
ASP A 145
GLY A 329
 None
 0.85A 5cdnA-1gk2A:
1.5
5cdnB-1gk2A:
undetectable		 5cdnA-1gk2A:
21.56
5cdnB-1gk2A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 9 SER A 139
ALA A 199
ALA A 202
GLY A 144
GLY A 196
 None
 1.08A 5d0xK-1gk2A:
undetectable
5d0xL-1gk2A:
undetectable		 5d0xK-1gk2A:
18.15
5d0xL-1gk2A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 9 SER A 139
ALA A 199
ALA A 202
GLY A 144
GLY A 196
 None
 1.08A 5d0xY-1gk2A:
undetectable
5d0xZ-1gk2A:
undetectable		 5d0xY-1gk2A:
18.15
5d0xZ-1gk2A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 PHE A  59
SER A  64
ALA A  63
LEU A  61
 None
 1.24A 5dzkB-1gk2A:
0.5
5dzkP-1gk2A:
undetectable		 5dzkB-1gk2A:
19.22
5dzkP-1gk2A:
0.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 SER A 263
SER A 264
SER A 267
SER A 458
 None
 1.49A 5hswA-1gk2A:
0.0		 5hswA-1gk2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		3 / 3 ALA A 337
ASN A 340
LEU A 341
 None
 0.46A 5i1oA-1gk2A:
0.0		 5i1oA-1gk2A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 LEU A 341
ALA A 204
LEU A 208
THR A 201
 None
 1.25A 5l4iB-1gk2A:
undetectable		 5l4iB-1gk2A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 6 LEU A 438
VAL A 489
LEU A 427
GLU A 212
 None
 0.96A 5tudD-1gk2A:
0.0		 5tudD-1gk2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 ARG A 355
PHE A 256
LEU A 260
LEU A 497
 None
 1.10A 5veuH-1gk2A:
1.3		 5veuH-1gk2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 7 LEU A 303
LEU A 293
GLY A 424
LEU A 427
ILE A 348
 None
 1.25A 5vkqA-1gk2A:
1.2
5vkqB-1gk2A:
1.2		 5vkqA-1gk2A:
15.46
5vkqB-1gk2A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 8 LEU A 303
LEU A 293
GLY A 424
LEU A 427
ILE A 348
 None
 1.26A 5vkqB-1gk2A:
1.2
5vkqC-1gk2A:
1.2		 5vkqB-1gk2A:
15.46
5vkqC-1gk2A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		5 / 12 MET A 289
ALA A 346
SER A 350
GLU A 353
LEU A 351
 None
 1.21A 5vlmB-1gk2A:
undetectable		 5vlmB-1gk2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 5 HIS A 330
ALA A 335
SER A 418
GLY A 141
 None
 1.28A 5yodD-1gk2A:
undetectable		 5yodD-1gk2A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 7 ASN A 433
ALA A 392
GLU A 347
LEU A 398
 None
 1.04A 6ci6A-1gk2A:
1.3		 6ci6A-1gk2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		4 / 4 VAL A 226
GLY A 231
ASP A 278
ASP A 274
 None
 1.47A 6cjkC-1gk2A:
undetectable		 6cjkC-1gk2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1gk2 HISTIDINE
AMMONIA-LYASE
(Pseudomonas
putida) 		6 / 10 VAL A 118
ALA A 121
LEU A 185
LEU A 157
LEU A 194
LEU A 193
 None
 1.43A 6f6nA-1gk2A:
0.0
6f6nB-1gk2A:
0.0		 6f6nA-1gk2A:
10.88
6f6nB-1gk2A:
10.87