SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 HIS A  59
HIS A 183
HIS A 239
ASP A 315
 ZN  A1461 (-3.4A)
ZN  A1460 (-3.2A)
ZN  A1460 (-3.5A)
ZN  A1461 (-2.7A)
 0.53A 1e9yB-1gkpA:
23.5		 1e9yB-1gkpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 PHE A 224
ILE A 151
LEU A 228
VAL A 180
 None
KCX  A 150 ( 4.0A)
None
None
 0.84A 1fslA-1gkpA:
undetectable		 1fslA-1gkpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 PHE A 224
ILE A 151
LEU A 228
VAL A 180
 None
KCX  A 150 ( 4.0A)
None
None
 0.80A 1fslB-1gkpA:
undetectable		 1fslB-1gkpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 6 HIS A  59
HIS A  61
HIS A 183
HIS A 239
ASP A 315
 ZN  A1461 (-3.4A)
ZN  A1461 (-3.4A)
ZN  A1460 (-3.2A)
ZN  A1460 (-3.5A)
ZN  A1461 (-2.7A)
 0.54A 1fweC-1gkpA:
24.3		 1fweC-1gkpA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 GLU A  24
ARG A 432
LYS A 450
ASP A 120
 None
 1.47A 1k4tA-1gkpA:
0.0		 1k4tA-1gkpA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 TYR A 414
VAL A 345
ILE A 341
MET A 287
 None
 1.45A 1opjA-1gkpA:
0.0		 1opjA-1gkpA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 4 HIS A 239
VAL A 264
THR A 181
LEU A 374
 ZN  A1460 (-3.5A)
None
KCX  A 150 ( 4.3A)
None
 1.46A 1oq5A-1gkpA:
0.0		 1oq5A-1gkpA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 8 ALA A  13
ASP A  14
ILE A 384
GLY A 382
ILE A  56
 None
 1.30A 1sh9A-1gkpA:
undetectable		 1sh9A-1gkpA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 11 ASP A 315
HIS A  59
GLU A 185
HIS A 239
SER A 288
 ZN  A1461 (-2.7A)
ZN  A1461 (-3.4A)
None
ZN  A1460 (-3.5A)
None
 1.22A 2q0jB-1gkpA:
undetectable		 2q0jB-1gkpA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 7 PRO A  58
LEU A 374
PHE A 375
THR A 311
 None
 0.91A 2vl2B-1gkpA:
undetectable		 2vl2B-1gkpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		6 / 12 GLY A   8
ALA A  46
ASP A  45
VAL A 428
THR A 430
VAL A 394
 None
 1.32A 3el5B-1gkpA:
undetectable		 3el5B-1gkpA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 1gkp HYDANTOINASE
(Thermus
sp.) 		3 / 3 GLU A 185
GLY A 220
THR A 221
 None
 0.48A 3iazA-1gkpA:
0.0		 3iazA-1gkpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 4 PRO A 397
TYR A  50
GLY A  48
THR A  47
 None
 1.39A 3ib0A-1gkpA:
0.0		 3ib0A-1gkpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 TYR A  17
GLY A  48
ALA A  46
ILE A  21
 None
 0.75A 3jusA-1gkpA:
0.0		 3jusA-1gkpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 TYR A  17
GLY A  48
ALA A  46
ILE A  21
 None
 0.75A 3jusA-1gkpA:
0.0		 3jusA-1gkpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 TYR A  17
GLY A  48
ALA A  46
ILE A  21
 None
 0.80A 3jusB-1gkpA:
undetectable		 3jusB-1gkpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 9 GLY A 440
ILE A 422
PHE A 363
GLY A  86
PHE A  55
 None
 1.37A 3ko0A-1gkpA:
undetectable
3ko0C-1gkpA:
undetectable		 3ko0A-1gkpA:
14.50
3ko0C-1gkpA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 10 GLY A  86
PHE A  55
GLY A 440
ILE A 422
PHE A 363
 None
 1.22A 3ko0L-1gkpA:
undetectable
3ko0N-1gkpA:
undetectable		 3ko0L-1gkpA:
14.50
3ko0N-1gkpA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 PHE A 417
GLU A 281
TYR A 285
LEU A 270
 None
 1.06A 3rqwC-1gkpA:
undetectable
3rqwD-1gkpA:
undetectable		 3rqwC-1gkpA:
18.24
3rqwD-1gkpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 PHE A 417
GLU A 281
TYR A 285
LEU A 270
 None
 1.05A 3rqwI-1gkpA:
0.0
3rqwJ-1gkpA:
undetectable		 3rqwI-1gkpA:
18.24
3rqwJ-1gkpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 GLU A 281
TYR A 285
LEU A 270
PHE A 417
 None
 1.03A 3rqwF-1gkpA:
undetectable
3rqwJ-1gkpA:
undetectable		 3rqwF-1gkpA:
18.24
3rqwJ-1gkpA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 7 GLY A 424
PRO A 397
TYR A  50
GLY A  48
THR A  47
 None
 1.41A 3tajA-1gkpA:
undetectable		 3tajA-1gkpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 6 GLU A 418
ASP A 343
ASP A 413
GLU A 342
 None
 1.30A 3vywA-1gkpA:
undetectable		 3vywA-1gkpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 GLU A 418
ASP A 343
ASP A 413
GLU A 342
 None
 1.38A 3vywD-1gkpA:
undetectable		 3vywD-1gkpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 HIS A  59
HIS A 183
HIS A 239
ASP A 315
 ZN  A1461 (-3.4A)
ZN  A1460 (-3.2A)
ZN  A1460 (-3.5A)
ZN  A1461 (-2.7A)
 0.47A 4h9mA-1gkpA:
25.2		 4h9mA-1gkpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		6 / 12 GLY A  32
ALA A  19
ASP A  20
VAL A  51
ILE A   5
ILE A  10
 None
 1.44A 4jecA-1gkpA:
undetectable		 4jecA-1gkpA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 GLU A 185
ARG A 212
PRO A 289
SER A 241
 None
 1.29A 4k17B-1gkpA:
undetectable		 4k17B-1gkpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 LEU A 269
LEU A 270
ASN A 415
ILE A 403
 None
 0.79A 4lzrA-1gkpA:
undetectable		 4lzrA-1gkpA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1gkp HYDANTOINASE
(Thermus
sp.) 		3 / 3 ALA A 275
GLN A 194
GLY A 191
 None
 0.57A 4odoC-1gkpA:
undetectable		 4odoC-1gkpA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 8 LYS A 370
ALA A 371
GLY A 376
LEU A 377
 SO4  A1462 (-2.7A)
None
None
None
 0.86A 4po0A-1gkpA:
undetectable		 4po0A-1gkpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 6 HIS A  59
HIS A  61
HIS A 183
HIS A 239
ASP A 315
 ZN  A1461 (-3.4A)
ZN  A1461 (-3.4A)
ZN  A1460 (-3.2A)
ZN  A1460 (-3.5A)
ZN  A1461 (-2.7A)
 0.44A 4ubpC-1gkpA:
24.5		 4ubpC-1gkpA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1gkp HYDANTOINASE
(Thermus
sp.) 		4 / 5 ASP A 131
VAL A 161
ASP A 162
GLY A 164
 None
 1.19A 4xp6A-1gkpA:
0.1		 4xp6A-1gkpA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gkp HYDANTOINASE
(Thermus
sp.) 		5 / 12 GLY A  85
GLY A  86
THR A  87
GLU A 342
ILE A 341
 None
 1.27A 4zvmA-1gkpA:
undetectable
4zvmB-1gkpA:
undetectable		 4zvmA-1gkpA:
19.91
4zvmB-1gkpA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1gkp HYDANTOINASE
(Thermus
sp.) 		3 / 3 TRP A 301
ILE A 309
SER A 263
 None
 0.91A 5gqbA-1gkpA:
6.9		 5gqbA-1gkpA:
21.89