SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 5 HIS A  60
HIS A 183
HIS A 239
ASP A 312
 ZN  A1453 ( 3.3A)
ZN  A1452 ( 3.1A)
ZN  A1452 ( 3.4A)
ZN  A1453 ( 2.6A)
 0.43A 1e9yB-1gkrA:
23.2		 1e9yB-1gkrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 6 HIS A  60
HIS A  62
HIS A 183
HIS A 239
ASP A 312
 ZN  A1453 ( 3.3A)
ZN  A1453 ( 3.3A)
ZN  A1452 ( 3.1A)
ZN  A1452 ( 3.4A)
ZN  A1453 ( 2.6A)
 0.58A 1fweC-1gkrA:
24.1		 1fweC-1gkrA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 8 LEU A 346
PRO A 368
VAL A  56
GLY A  55
 None
 1.03A 1hrkA-1gkrA:
undetectable		 1hrkA-1gkrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 8 LEU A 346
PRO A 368
VAL A  56
GLY A  55
 None
 1.03A 1hrkB-1gkrA:
undetectable		 1hrkB-1gkrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 11 GLY A 264
HIS A  62
HIS A  60
GLY A 337
ILE A  63
 None
ZN  A1453 ( 3.3A)
ZN  A1453 ( 3.3A)
None
None
 1.00A 1jzsA-1gkrA:
undetectable		 1jzsA-1gkrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 ILE A  87
GLY A  86
VAL A  84
PRO A 343
ALA A 422
 None
 1.02A 1nv8B-1gkrA:
undetectable		 1nv8B-1gkrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 10 GLY A  49
ASP A  21
ILE A  22
ILE A  17
PRO A  54
 None
 1.00A 1sh9B-1gkrA:
undetectable		 1sh9B-1gkrA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 0.93A 2eikC-1gkrA:
undetectable
2eikJ-1gkrA:
0.0		 2eikC-1gkrA:
18.57
2eikJ-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.35A 2fj1A-1gkrA:
undetectable		 2fj1A-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		3 / 3 HIS A 239
ILE A 221
LEU A 235
 ZN  A1452 ( 3.4A)
None
None
 0.69A 2kceA-1gkrA:
0.0		 2kceA-1gkrA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.29A 2o7oA-1gkrA:
1.1		 2o7oA-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 MET A 417
ILE A 278
PRO A 343
GLY A 337
 None
 1.10A 2pnjB-1gkrA:
0.0		 2pnjB-1gkrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.30A 2tctA-1gkrA:
undetectable		 2tctA-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.42A 2xpvA-1gkrA:
0.0		 2xpvA-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.37A 2xrlA-1gkrA:
0.0		 2xrlA-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 5 ARG A 116
ASP A  65
ILE A  63
GLU A  76
 None
 1.40A 2xrzA-1gkrA:
0.4
2xrzB-1gkrA:
0.0		 2xrzA-1gkrA:
22.46
2xrzB-1gkrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.05A 3ablP-1gkrA:
undetectable
3ablW-1gkrA:
0.0		 3ablP-1gkrA:
18.57
3ablW-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 0.95A 3asnC-1gkrA:
undetectable
3asnJ-1gkrA:
undetectable		 3asnC-1gkrA:
18.57
3asnJ-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 125
GLY A 126
LEU A 103
CYH A 176
ILE A 169
 None
KCX  A 147 ( 3.7A)
None
None
None
 1.02A 3h52B-1gkrA:
undetectable		 3h52B-1gkrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 8 ILE A 236
ALA A 369
VAL A 144
VAL A 179
 None
 0.89A 3me6B-1gkrA:
0.0		 3me6B-1gkrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 8 GLU A  76
GLN A 112
ARG A  74
ASP A  65
 None
 1.12A 3mjrD-1gkrA:
1.3		 3mjrD-1gkrA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 4 LEU A 336
GLY A 337
LEU A 338
GLU A 339
 None
 0.93A 3tgvB-1gkrA:
undetectable		 3tgvB-1gkrA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 11 PHE A 158
SER A 148
VAL A 144
PHE A 372
VAL A 181
 None
KCX  A 147 ( 3.3A)
None
None
KCX  A 147 ( 4.7A)
 1.49A 3u9fM-1gkrA:
0.0
3u9fO-1gkrA:
0.0		 3u9fM-1gkrA:
18.48
3u9fO-1gkrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 181
ILE A  91
ILE A  87
SER A 311
LEU A 238
 KCX  A 147 ( 4.7A)
None
None
None
KCX  A 147 ( 4.8A)
 1.33A 4a84A-1gkrA:
undetectable		 4a84A-1gkrA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 11 VAL A 154
HIS A 239
HIS A 183
ASN A 333
HIS A  62
 None
ZN  A1452 ( 3.4A)
ZN  A1452 ( 3.1A)
None
ZN  A1453 ( 3.3A)
 1.22A 4c1fA-1gkrA:
undetectable
4c1fB-1gkrA:
undetectable		 4c1fA-1gkrA:
18.71
4c1fB-1gkrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 5 HIS A  60
HIS A 183
HIS A 239
ASP A 312
 ZN  A1453 ( 3.3A)
ZN  A1452 ( 3.1A)
ZN  A1452 ( 3.4A)
ZN  A1453 ( 2.6A)
 0.38A 4h9mA-1gkrA:
25.0		 4h9mA-1gkrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		3 / 3 SER A 341
MET A 345
ASP A 415
 None
 0.74A 4mm4B-1gkrA:
0.0		 4mm4B-1gkrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 6 HIS A  60
HIS A  62
HIS A 183
HIS A 239
ASP A 312
 ZN  A1453 ( 3.3A)
ZN  A1453 ( 3.3A)
ZN  A1452 ( 3.1A)
ZN  A1452 ( 3.4A)
ZN  A1453 ( 2.6A)
 0.44A 4ubpC-1gkrA:
26.2		 4ubpC-1gkrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.34A 4v2gB-1gkrA:
undetectable		 4v2gB-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.06A 5b1bC-1gkrA:
0.0
5b1bJ-1gkrA:
0.0		 5b1bC-1gkrA:
18.57
5b1bJ-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 ALA A 369
GLN A 382
SER A 385
PRO A  54
 None
 1.11A 5c6pA-1gkrA:
0.0		 5c6pA-1gkrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 4 VAL A  24
ALA A  41
ILE A  45
THR A  44
 None
 1.18A 5e4dB-1gkrA:
0.0		 5e4dB-1gkrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		3 / 3 TRP A 298
ILE A 306
SER A 263
 None
 0.88A 5gqbA-1gkrA:
5.5		 5gqbA-1gkrA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		3 / 3 GLY A  55
THR A 420
PRO A 423
 None
 0.59A 5v5zA-1gkrA:
0.0		 5v5zA-1gkrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 11 ILE A  95
HIS A 316
VAL A 284
SER A 153
HIS A  62
 None
None
None
None
ZN  A1453 ( 3.3A)
 1.37A 5z0mA-1gkrA:
undetectable
5z0mB-1gkrA:
0.0		 5z0mA-1gkrA:
11.14
5z0mB-1gkrA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.09A 5z86C-1gkrA:
undetectable
5z86J-1gkrA:
0.0		 5z86C-1gkrA:
18.57
5z86J-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.09A 5z86P-1gkrA:
undetectable
5z86W-1gkrA:
0.0		 5z86P-1gkrA:
18.57
5z86W-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.12A 5zcpC-1gkrA:
undetectable
5zcpJ-1gkrA:
0.0		 5zcpC-1gkrA:
18.57
5zcpJ-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 ILE A 169
LEU A 166
ILE A  95
ALA A 184
 None
 0.86A 6b5vA-1gkrA:
0.0
6b5vC-1gkrA:
0.0		 6b5vA-1gkrA:
10.25
6b5vC-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 ALA A 184
ILE A 169
LEU A 166
ILE A  95
 None
 0.89A 6b5vA-1gkrA:
0.0
6b5vB-1gkrA:
0.0		 6b5vA-1gkrA:
10.25
6b5vB-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 ILE A 169
LEU A 166
ILE A  95
ALA A 184
 None
 0.85A 6b5vC-1gkrA:
0.0
6b5vD-1gkrA:
0.0		 6b5vC-1gkrA:
10.25
6b5vD-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 7 ALA A 184
ILE A 169
LEU A 166
ILE A  95
 None
 0.86A 6b5vB-1gkrA:
0.0
6b5vD-1gkrA:
0.0		 6b5vB-1gkrA:
10.25
6b5vD-1gkrA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 5 LEU A 360
LEU A 392
THR A 347
ARG A 406
 None
 1.11A 6ew0F-1gkrA:
0.0		 6ew0F-1gkrA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 LEU A 360
LEU A 392
THR A 347
ARG A 406
 None
 1.11A 6ew0G-1gkrA:
undetectable		 6ew0G-1gkrA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 444
LEU A 117
THR A 431
GLY A 430
ASP A 388
 None
 1.16A 6gngA-1gkrA:
2.7		 6gngA-1gkrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE
(Paenarthrobacter
aurescens) 		4 / 6 MET A 344
THR A 347
LEU A 346
THR A 398
 None
 1.23A 6mvxA-1gkrA:
undetectable
6mvxB-1gkrA:
undetectable
6mvxC-1gkrA:
undetectable		 6mvxA-1gkrA:
19.07
6mvxB-1gkrA:
19.07
6mvxC-1gkrA:
19.07