SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1gl2 SYNTAXIN 8
(Rattus
norvegicus) 		3 / 3 ILE D 183
LEU D 186
VAL D 190
 None
 0.49A 1mz9B-1gl2D:
4.5		 1mz9B-1gl2D:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus) 		3 / 3 THR C 177
LEU C 181
LEU C 188
 None
 0.54A 1mz9C-1gl2C:
4.4		 1mz9C-1gl2C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus) 		3 / 3 THR C 184
LEU C 188
LEU C 195
 None
 0.58A 1mz9C-1gl2C:
4.4		 1mz9C-1gl2C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1gl2 ENDOBREVIN
SYNTAXIN 7
SYNTAXIN 8
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A  15
ILE D 161
ASP D 156
ILE B 175
LEU B 178
 None
 1.08A 2jn3A-1gl2A:
undetectable		 2jn3A-1gl2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus) 		3 / 3 GLU C 165
GLN C 173
ARG C 176
 None
 0.96A 2w3bB-1gl2C:
undetectable		 2w3bB-1gl2C:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
SYNTAXIN 8
(Mus
musculus;
Rattus
norvegicus) 		3 / 3 GLU D 175
GLN C 173
ARG C 176
 None
 0.80A 2w3bB-1gl2D:
undetectable		 2w3bB-1gl2D:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1gl2 SYNTAXIN 7
VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus;
Mus
musculus) 		3 / 3 ASP B 191
LEU B 192
GLN C 170
 None
 0.73A 3g4lA-1gl2B:
undetectable		 3g4lA-1gl2B:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1gl2 SYNTAXIN 7
SYNTAXIN 8
VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 ILE B 182
ALA B 180
GLN C 144
ARG B 171
LEU D 155
 None
 1.17A 3ix9B-1gl2B:
undetectable		 3ix9B-1gl2B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1gl2 SYNTAXIN 8
VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU C 167
ILE D 172
GLU D 175
LEU D 176
ASP D 177
 None
 1.23A 3ko0G-1gl2C:
undetectable
3ko0H-1gl2C:
undetectable
3ko0I-1gl2C:
undetectable
3ko0J-1gl2C:
undetectable		 3ko0G-1gl2C:
20.79
3ko0H-1gl2C:
20.79
3ko0I-1gl2C:
20.79
3ko0J-1gl2C:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 1gl2 SYNTAXIN 8
VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU C 167
ILE D 172
GLU D 175
LEU D 176
ASP D 177
 None
 1.19A 3ko0M-1gl2C:
undetectable
3ko0N-1gl2C:
undetectable
3ko0O-1gl2C:
undetectable
3ko0P-1gl2C:
undetectable		 3ko0M-1gl2C:
20.79
3ko0N-1gl2C:
20.79
3ko0O-1gl2C:
20.79
3ko0P-1gl2C:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1
(Mus
musculus) 		3 / 3 LEU C 181
LYS C 178
THR C 177
 None
 0.62A 4lj0A-1gl2C:
0.0		 4lj0A-1gl2C:
14.29