SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 THR A 338
SER A 339
TYR A 395
LEU A 403
 None
 1.09A 1ibgL-1gl6A:
0.0		 1ibgL-1gl6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 VAL A 204
TRP A 185
HIS A 291
LEU A 288
 None
 1.23A 1pk2A-1gl6A:
0.0		 1pk2A-1gl6A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.92A 1v54N-1gl6A:
0.2
1v54W-1gl6A:
0.0		 1v54N-1gl6A:
21.30
1v54W-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.92A 1v55A-1gl6A:
undetectable
1v55J-1gl6A:
undetectable		 1v55A-1gl6A:
21.30
1v55J-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.88A 1v55N-1gl6A:
0.0
1v55W-1gl6A:
0.0		 1v55N-1gl6A:
21.30
1v55W-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 PHE A 407
LEU A 358
LEU A 353
LEU A 379
 None
 0.93A 2bfpC-1gl6A:
undetectable		 2bfpC-1gl6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.85A 2dyrN-1gl6A:
0.2
2dyrW-1gl6A:
0.0		 2dyrN-1gl6A:
21.30
2dyrW-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.89A 2eikN-1gl6A:
undetectable
2eikW-1gl6A:
0.0		 2eikN-1gl6A:
21.30
2eikW-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.88A 2eilN-1gl6A:
0.3
2eilW-1gl6A:
0.0		 2eilN-1gl6A:
21.30
2eilW-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.93A 2einA-1gl6A:
0.0
2einJ-1gl6A:
0.0		 2einA-1gl6A:
21.30
2einJ-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 5 GLY A 378
TRP A 352
ARG A 380
LEU A 351
 None
 1.34A 2j2pD-1gl6A:
0.0
2j2pF-1gl6A:
0.0		 2j2pD-1gl6A:
20.14
2j2pF-1gl6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1gl6 ATPASE
(Escherichia
coli) 		6 / 12 LEU A 127
GLY A 384
LEU A 413
ILE A 355
LEU A 385
LEU A 391
 None
 1.47A 2nxeA-1gl6A:
3.0		 2nxeA-1gl6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1gl6 ATPASE
(Escherichia
coli) 		3 / 3 ARG A 483
GLN A 109
PRO A 118
 None
 0.85A 2qhfA-1gl6A:
undetectable		 2qhfA-1gl6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.94A 3ag3A-1gl6A:
0.2
3ag3J-1gl6A:
0.0		 3ag3A-1gl6A:
21.30
3ag3J-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.79A 3ag3N-1gl6A:
0.1
3ag3W-1gl6A:
0.0		 3ag3N-1gl6A:
21.30
3ag3W-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.91A 3asoN-1gl6A:
0.2
3asoW-1gl6A:
undetectable		 3asoN-1gl6A:
21.30
3asoW-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 6 VAL A 381
GLY A 478
ARG A 483
LEU A  99
 None
 0.86A 3bjwE-1gl6A:
undetectable		 3bjwE-1gl6A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 LEU A 353
ALA A 383
LEU A 403
LEU A 361
LEU A 371
 None
 1.06A 3erdA-1gl6A:
undetectable		 3erdA-1gl6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 LEU A 364
ASP A 334
SER A 366
GLU A 214
 None
 1.31A 4aq7A-1gl6A:
0.0		 4aq7A-1gl6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 10 VAL A 411
LEU A 126
VAL A 128
LEU A 143
VAL A 382
 None
 1.05A 4e3hA-1gl6A:
undetectable		 4e3hA-1gl6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 11 PHE A 502
GLY A 322
ALA A 324
LEU A 325
GLU A 290
 None
 1.16A 4l8fB-1gl6A:
undetectable		 4l8fB-1gl6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 11 PHE A 502
GLY A 322
ALA A 324
LEU A 325
GLU A 290
 None
 1.15A 4l8fD-1gl6A:
undetectable		 4l8fD-1gl6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 LEU A 353
ARG A 153
LEU A 313
SER A 339
 None
 1.19A 4qknA-1gl6A:
0.0		 4qknA-1gl6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 8 ILE A 173
LEU A 325
VAL A 333
PHE A 299
 None
 0.93A 4r38B-1gl6A:
undetectable		 4r38B-1gl6A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 VAL A 335
SER A 339
ILE A 301
SER A 300
HIS A 291
 None
 1.49A 4rujA-1gl6A:
0.0		 4rujA-1gl6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1gl6 ATPASE
(Escherichia
coli) 		3 / 3 ARG A 150
GLN A 109
GLU A 122
 None
 0.93A 4tvtA-1gl6A:
0.0		 4tvtA-1gl6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 6 GLY A 161
ASN A 160
ILE A 315
TRP A 317
 None
 0.88A 5j4nA-1gl6A:
0.0		 5j4nA-1gl6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 6 GLY A 161
ASN A 160
ILE A 315
TRP A 317
 None
 0.91A 5j4nB-1gl6A:
0.2		 5j4nB-1gl6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 ILE A 467
GLY A 415
THR A 132
LEU A 410
MET A 426
 None
None
GNP  A 701 (-4.7A)
None
None
 0.91A 5nfjA-1gl6A:
undetectable		 5nfjA-1gl6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 LEU A 413
SER A 409
VAL A 411
ALA A 486
GLY A 478
 None
 0.94A 5tzoB-1gl6A:
undetectable		 5tzoB-1gl6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 7 ARG A 350
GLU A 346
PRO A 308
PRO A 344
 None
 1.44A 6a4iB-1gl6A:
undetectable		 6a4iB-1gl6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1gl6 ATPASE
(Escherichia
coli) 		3 / 3 TYR A 195
ALA A 201
LEU A 202
 None
 0.63A 6ag0C-1gl6A:
undetectable		 6ag0C-1gl6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 ILE A 355
LEU A 313
VAL A 336
LEU A 358
LEU A 371
 None
 1.08A 6b52A-1gl6A:
undetectable		 6b52A-1gl6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 ILE A 355
LEU A 313
VAL A 336
LEU A 358
LEU A 403
 None
 1.12A 6b54A-1gl6A:
undetectable		 6b54A-1gl6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 1gl6 ATPASE
(Escherichia
coli) 		3 / 3 GLU A 399
LEU A 403
ARG A 404
 None
 0.53A 6d8fA-1gl6A:
0.0		 6d8fA-1gl6A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 6 GLY A 384
LEU A 358
VAL A 112
PHE A 479
 None
 0.91A 6h7lA-1gl6A:
0.0		 6h7lA-1gl6A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1gl6 ATPASE
(Escherichia
coli) 		4 / 6 GLY A 384
LEU A 358
VAL A 112
PHE A 479
 None
 0.91A 6h7lB-1gl6A:
0.0		 6h7lB-1gl6A:
11.24