SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1glo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1glo CATHEPSIN S
(Homo
sapiens) 		4 / 6 TYR A 148
HIS A 205
GLU A 192
VAL A 182
 None
 1.15A 1q13A-1gloA:
undetectable		 1q13A-1gloA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1glo CATHEPSIN S
(Homo
sapiens) 		6 / 10 GLN A  19
GLY A  23
TRP A  26
PHE A  28
SER A  29
HIS A 164
 None
 0.33A 1stfE-1gloA:
34.3
1stfI-1gloA:
1.3		 1stfE-1gloA:
42.79
1stfI-1gloA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1glo CATHEPSIN S
(Homo
sapiens) 		3 / 3 LYS A   1
TYR A 171
PRO A   2
 None
 1.13A 2j9cC-1gloA:
0.0		 2j9cC-1gloA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1glo CATHEPSIN S
(Homo
sapiens) 		5 / 10 PHE A  28
ASN A  63
GLY A  68
ALA A  24
GLN A  19
 None
 1.30A 2x2iB-1gloA:
undetectable		 2x2iB-1gloA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1glo CATHEPSIN S
(Homo
sapiens) 		5 / 10 SER A  29
SER A 135
GLY A  68
ALA A  24
GLN A  19
 None
 1.49A 2x2iB-1gloA:
undetectable		 2x2iB-1gloA:
12.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1glo CATHEPSIN S
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 164
TRP A 186
 None
 0.35A 3ai8A-1gloA:
28.4		 3ai8A-1gloA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1glo CATHEPSIN S
(Homo
sapiens) 		3 / 3 SER A  57
GLY A  62
GLY A  69
 None
 0.54A 3bogA-1gloA:
0.0
3bogC-1gloA:
0.0		 3bogA-1gloA:
undetectable
3bogC-1gloA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1glo CATHEPSIN S
(Homo
sapiens) 		3 / 3 ASN A 201
GLU A 121
ARG A 200
 None
 1.04A 3wxoA-1gloA:
undetectable		 3wxoA-1gloA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1glo CATHEPSIN S
(Homo
sapiens) 		5 / 9 LEU A 124
GLY A 170
VAL A 134
SER A 135
VAL A 136
 None
 1.15A 4qd3A-1gloA:
undetectable		 4qd3A-1gloA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1glo CATHEPSIN S
(Homo
sapiens) 		5 / 9 ASP A  87
ALA A  30
PHE A  28
SER A  47
GLY A  32
 None
 1.36A 6awoA-1gloA:
undetectable		 6awoA-1gloA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1glo CATHEPSIN S
(Homo
sapiens) 		5 / 9 ASP A  87
ALA A  30
PHE A  28
SER A  47
GLY A  32
 None
 1.36A 6awqA-1gloA:
undetectable		 6awqA-1gloA:
17.80