SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 ILE A 257
ARG A 270
TYR A 150
PHE A 314
 None
 1.39A 1e73M-1gm5A:
0.0		 1e73M-1gm5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 7 THR A 313
LEU A 317
GLY A 307
LEU A 299
 None
 0.94A 1gtiB-1gm5A:
undetectable		 1gtiB-1gm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 7 THR A 313
LEU A 317
GLY A 307
LEU A 299
 None
 1.05A 1gtiE-1gm5A:
undetectable		 1gtiE-1gm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 12 LEU A 100
LEU A  67
LEU A  59
LEU A  63
LEU A  53
 None
 1.16A 1mx1C-1gm5A:
undetectable		 1mx1C-1gm5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 9 VAL A 221
TRP A 203
LEU A 216
TYR A 212
LEU A 213
 None
 1.03A 1pbfA-1gm5A:
0.6		 1pbfA-1gm5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 8 ARG A 501
GLY A 477
VAL A 424
ILE A 476
 None
 0.79A 1pk7B-1gm5A:
undetectable		 1pk7B-1gm5A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 12 VAL A 197
LEU A 213
ALA A 190
LEU A 201
VAL A 221
 None
 1.16A 1sa1C-1gm5A:
1.2
1sa1D-1gm5A:
undetectable		 1sa1C-1gm5A:
20.81
1sa1D-1gm5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 LEU A 671
PHE A 708
ARG A 680
 None
 0.84A 1xdkB-1gm5A:
0.0		 1xdkB-1gm5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 LEU A 671
PHE A 708
ARG A 680
 None
 0.85A 1xdkF-1gm5A:
undetectable		 1xdkF-1gm5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 LEU A 633
PRO A 656
ALA A 636
ILE A 653
 None
 1.05A 2aofB-1gm5A:
undetectable		 2aofB-1gm5A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 10 THR A 170
VAL A 199
VAL A 191
VAL A 243
VAL A 223
 None
 1.47A 2qboA-1gm5A:
undetectable		 2qboA-1gm5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 ASP A 745
TYR A 747
PHE A 330
TYR A 326
 None
 1.02A 2w98A-1gm5A:
undetectable
2w98B-1gm5A:
2.7		 2w98A-1gm5A:
18.27
2w98B-1gm5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.16A 2y69C-1gm5A:
2.9
2y69J-1gm5A:
0.0		 2y69C-1gm5A:
15.64
2y69J-1gm5A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.25A 2y69P-1gm5A:
3.0
2y69W-1gm5A:
0.2		 2y69P-1gm5A:
15.64
2y69W-1gm5A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.07A 3ablP-1gm5A:
2.9
3ablW-1gm5A:
0.0		 3ablP-1gm5A:
15.64
3ablW-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.17A 3abmC-1gm5A:
3.0
3abmJ-1gm5A:
0.0		 3abmC-1gm5A:
15.64
3abmJ-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.18A 3abmP-1gm5A:
2.9
3abmW-1gm5A:
0.0		 3abmP-1gm5A:
15.64
3abmW-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.09A 3ag3C-1gm5A:
2.9
3ag3J-1gm5A:
0.0		 3ag3C-1gm5A:
15.64
3ag3J-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 9 LEU A 201
VAL A 227
ILE A 156
ALA A 241
ILE A 238
 None
 0.93A 3el0B-1gm5A:
undetectable		 3el0B-1gm5A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 12 GLY A 682
GLY A 685
GLU A 553
ALA A 688
TYR A 689
 None
 1.23A 3sxjA-1gm5A:
undetectable		 3sxjA-1gm5A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 12 GLY A 682
GLY A 685
GLU A 553
ALA A 688
TYR A 689
 None
 1.22A 3sxjB-1gm5A:
undetectable		 3sxjB-1gm5A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 12 GLY A 682
GLY A 685
GLU A 553
ALA A 688
TYR A 689
 None
 1.26A 3t7sC-1gm5A:
undetectable		 3t7sC-1gm5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 SER A 427
LEU A 429
HIS A 433
THR A 478
 None
 1.45A 3thrB-1gm5A:
4.1		 3thrB-1gm5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 ASP A 721
GLU A 667
GLY A 670
GLU A 729
 None
 1.41A 3w9tA-1gm5A:
0.0		 3w9tA-1gm5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 ASP A 721
GLU A 667
GLY A 670
GLU A 729
 None
 1.40A 3w9tC-1gm5A:
0.0		 3w9tC-1gm5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 ASP A 721
GLU A 667
GLY A 670
GLU A 729
 None
 1.40A 3w9tD-1gm5A:
0.0		 3w9tD-1gm5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 ASP A 721
GLU A 667
GLY A 670
GLU A 729
 None
 1.41A 3w9tG-1gm5A:
0.0		 3w9tG-1gm5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.02A 3wg7C-1gm5A:
2.9
3wg7J-1gm5A:
0.0		 3wg7C-1gm5A:
15.64
3wg7J-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.06A 5b1bC-1gm5A:
2.9
5b1bJ-1gm5A:
0.2		 5b1bC-1gm5A:
15.64
5b1bJ-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 ILE A 649
ILE A 663
MET A 619
 None
 0.52A 5i9yA-1gm5A:
undetectable		 5i9yA-1gm5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1gm5 RECG
(Thermotoga
maritima) 		5 / 10 LEU A 491
ASP A 412
ILE A 380
ILE A 496
VAL A 517
 None
 1.07A 5kr1A-1gm5A:
undetectable		 5kr1A-1gm5A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 MET A 308
GLU A 318
ARG A 321
 None
 0.93A 5tjyA-1gm5A:
undetectable		 5tjyA-1gm5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 MET A 308
GLU A 318
ARG A 321
 None
 0.94A 5tjzA-1gm5A:
undetectable		 5tjzA-1gm5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.07A 5wauC-1gm5A:
2.9
5wauJ-1gm5A:
0.0		 5wauC-1gm5A:
15.64
5wauJ-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.10A 5wauc-1gm5A:
2.9
5wauj-1gm5A:
0.0		 5wauc-1gm5A:
15.64
5wauj-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 THR A 709
THR A 556
ARG A 678
 None
 0.86A 5wm2A-1gm5A:
undetectable		 5wm2A-1gm5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.15A 5xdqC-1gm5A:
3.1
5xdqJ-1gm5A:
0.2		 5xdqC-1gm5A:
15.64
5xdqJ-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 5 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.15A 5xdqP-1gm5A:
3.0
5xdqW-1gm5A:
0.0		 5xdqP-1gm5A:
15.64
5xdqW-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1gm5 RECG
(Thermotoga
maritima) 		3 / 3 LYS A 246
PRO A 245
LYS A 219
 None
 1.25A 5y9yA-1gm5A:
0.0		 5y9yA-1gm5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 6 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.11A 5z86C-1gm5A:
3.0
5z86J-1gm5A:
0.2		 5z86C-1gm5A:
15.64
5z86J-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1gm5 RECG
(Thermotoga
maritima) 		4 / 7 VAL A 405
ILE A 495
GLY A 348
ARG A 375
 None
 0.85A 6hd6B-1gm5A:
undetectable		 6hd6B-1gm5A:
8.66