SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 12 ILE A  42
VAL A  73
LEU A  44
LEU A 105
ILE A 100
 None
 0.92A 1kqwA-1gmiA:
0.1		 1kqwA-1gmiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 12 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 0.94A 3datA-1gmiA:
undetectable		 3datA-1gmiA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 10 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.04A 3fl9A-1gmiA:
undetectable		 3fl9A-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 12 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.04A 3fl9B-1gmiA:
undetectable		 3fl9B-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 9 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.04A 3fl9D-1gmiA:
undetectable		 3fl9D-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 10 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.05A 3fl9E-1gmiA:
undetectable		 3fl9E-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 10 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.03A 3fl9F-1gmiA:
undetectable		 3fl9F-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 12 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.08A 3fl9G-1gmiA:
undetectable		 3fl9G-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 10 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
 None
 1.01A 3jw5B-1gmiA:
undetectable		 3jw5B-1gmiA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		4 / 8 ILE A  10
ALA A  43
THR A  54
VAL A 127
 None
 0.90A 3me6B-1gmiA:
undetectable		 3me6B-1gmiA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 12 LEU A  38
TRP A  65
LEU A  18
ILE A 117
ALA A  82
 None
 1.22A 5ienB-1gmiA:
0.0		 5ienB-1gmiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		4 / 8 GLY A  90
ILE A  89
ASP A  93
HIS A  85
 None
 0.98A 6ag0C-1gmiA:
undetectable		 6ag0C-1gmiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1gmi PROTEIN KINASE C,
EPSILON TYPE
(Rattus
rattus) 		5 / 12 ILE A  79
LEU A 106
PHE A   4
ASP A 130
ILE A  12
 None
 0.85A 6dwnB-1gmiA:
undetectable		 6dwnB-1gmiA:
20.86