SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PHE A 126
ILE A 102
HIS A 109
LEU A 111
 None
 0.86A 1fslA-1gmmA:
undetectable		 1fslA-1gmmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PHE A 126
ILE A 102
HIS A 109
LEU A 111
 None
 0.85A 1fslB-1gmmA:
undetectable		 1fslB-1gmmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		5 / 10 TYR A  40
ILE A  32
PRO A 118
GLU A  36
ILE A  35
 None
None
NA  A1131 (-4.5A)
None
NA  A1131 (-4.1A)
 1.37A 2dm6A-1gmmA:
undetectable
2dm6B-1gmmA:
undetectable		 2dm6A-1gmmA:
15.64
2dm6B-1gmmA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		6 / 12 GLY A  62
ALA A  63
ASP A  64
GLY A 117
ILE A  35
THR A  85
 None
None
None
None
NA  A1131 (-4.1A)
None
 1.47A 3d1xA-1gmmA:
undetectable		 3d1xA-1gmmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		6 / 11 GLY A  62
ALA A  63
ASP A  64
GLY A 117
ILE A  35
THR A  85
 None
None
None
None
NA  A1131 (-4.1A)
None
 1.47A 3ekxA-1gmmA:
undetectable		 3ekxA-1gmmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		6 / 12 GLY A  62
ALA A  63
ASP A  64
GLY A 117
ILE A  35
THR A  85
 None
None
None
None
NA  A1131 (-4.1A)
None
 1.47A 3el5B-1gmmA:
undetectable		 3el5B-1gmmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		5 / 8 GLY A  62
ALA A  63
ASP A  64
GLY A 117
ILE A  35
 None
None
None
None
NA  A1131 (-4.1A)
 1.37A 3so9A-1gmmA:
undetectable		 3so9A-1gmmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A  82
SER A 116
THR A  67
PHE A 115
 None
 1.05A 4ac9C-1gmmA:
undetectable		 4ac9C-1gmmA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		5 / 9 PHE A 126
ILE A  69
VAL A 114
GLY A  82
THR A  79
 None
 1.23A 4r20B-1gmmA:
undetectable		 4r20B-1gmmA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A  59
ILE A 121
ILE A   7
PHE A 115
ILE A 102
 None
 1.05A 5hw8B-1gmmA:
undetectable
5hw8F-1gmmA:
undetectable
5hw8G-1gmmA:
undetectable		 5hw8B-1gmmA:
21.01
5hw8F-1gmmA:
21.01
5hw8G-1gmmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1gmm CBM6
(Ruminiclostridiu
m
thermocellum) 		5 / 8 GLY A  82
LEU A  71
GLN A  70
THR A  79
LEU A 111
 None
 1.45A 6czmD-1gmmA:
0.0
6czmF-1gmmA:
undetectable		 6czmD-1gmmA:
16.01
6czmF-1gmmA:
16.01