SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 7 ARG A 223
ASP A 264
ASP A 260
TYR A 221
 PTR  A 216 ( 2.9A)
None
None
None
 1.41A 1cebA-1gngA:
undetectable		 1cebA-1gngA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 ILE A 177
SER A 242
ILE A 182
ASN A 186
LEU A 198
 None
 1.04A 1dlsA-1gngA:
undetectable		 1dlsA-1gngA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 LEU A 153
TYR A 146
LEU A 160
LEU A 350
PRO A 351
 None
 1.44A 1p33B-1gngA:
0.0		 1p33B-1gngA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 11 PHE A 340
PHE A 339
SER A 168
LEU A 187
VAL A 139
 None
 1.23A 1q23J-1gngA:
0.0		 1q23J-1gngA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 6 ILE A  62
VAL A  70
ILE A 109
ILE A 177
 None
 0.57A 1uwhA-1gngA:
21.8		 1uwhA-1gngA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 6 ILE A  62
VAL A  70
ILE A 109
ILE A 177
 None
 0.58A 1uwhB-1gngA:
21.6		 1uwhB-1gngA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 7 ILE A  62
LYS A  85
ILE A 109
ILE A 177
 None
 0.73A 1uwjA-1gngA:
8.1		 1uwjA-1gngA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 11 VAL A 158
GLU A 249
ALA A 248
ALA A 243
PHE A 305
 None
 1.35A 2admB-1gngA:
undetectable		 2admB-1gngA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		8 / 12 VAL A  70
ALA A  83
LYS A  85
GLU A  97
MET A 101
VAL A 110
TYR A 134
LEU A 188
 None
 0.78A 2pl0A-1gngA:
21.1		 2pl0A-1gngA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gng FRATTIDE
GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 11 VAL X 217
ALA X 216
PHE A 257
THR A 275
ILE X 213
 None
 1.27A 3n23A-1gngX:
undetectable		 3n23A-1gngX:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 LEU A 247
PHE A 339
VAL A 158
PHE A 305
CYH A 317
 None
 1.43A 3u9fD-1gngA:
0.0
3u9fE-1gngA:
0.0		 3u9fD-1gngA:
16.62
3u9fE-1gngA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 THR A 152
LEU A 247
PHE A 339
VAL A 158
CYH A 317
 None
 1.40A 3u9fD-1gngA:
0.0
3u9fE-1gngA:
0.0		 3u9fD-1gngA:
16.62
3u9fE-1gngA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 LEU A 247
PHE A 339
VAL A 158
PHE A 305
CYH A 317
 None
 1.49A 3u9fG-1gngA:
0.0
3u9fH-1gngA:
0.0		 3u9fG-1gngA:
16.62
3u9fH-1gngA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 THR A 152
LEU A 247
PHE A 339
VAL A 158
CYH A 317
 None
 1.42A 3u9fJ-1gngA:
0.1
3u9fK-1gngA:
undetectable		 3u9fJ-1gngA:
16.62
3u9fK-1gngA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		6 / 12 ILE A  62
GLY A  65
GLY A  68
VAL A  70
ALA A  83
LYS A  85
 None
 0.78A 3v5wA-1gngA:
8.9		 3v5wA-1gngA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 5 LYS A  85
ILE A 100
VAL A 110
LEU A 188
 None
 0.59A 3wzdA-1gngA:
20.5		 3wzdA-1gngA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 8 VAL A 110
LEU A 188
CYH A 199
ASP A 200
 None
 0.68A 3wzeA-1gngA:
20.8		 3wzeA-1gngA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 9 ILE A 100
MET A 101
LEU A 104
ILE A 109
TYR A 134
 None
 0.62A 3zosA-1gngA:
20.2		 3zosA-1gngA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 9 ILE A 100
MET A 101
LEU A 104
ILE A 109
TYR A 134
 None
 0.59A 3zosB-1gngA:
20.3		 3zosB-1gngA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
GLU A  97
ILE A 100
MET A 101
TYR A 134
LEU A 188
 None
 0.50A 4bkjA-1gngA:
20.5		 4bkjA-1gngA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		8 / 12 VAL A  70
ALA A  83
GLU A  97
ILE A 100
MET A 101
VAL A 110
TYR A 134
LEU A 188
 None
 0.96A 4csvA-1gngA:
21.9		 4csvA-1gngA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 12 ILE A 177
SER A 242
ILE A 182
ASN A 186
LEU A 198
 None
 0.82A 4gh8A-1gngA:
undetectable		 4gh8A-1gngA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		6 / 10 VAL A  70
GLU A  97
LEU A 104
ILE A 109
VAL A 110
TYR A 134
 None
 0.82A 4u0iA-1gngA:
20.4		 4u0iA-1gngA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gng FRATTIDE
GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 8 ILE A 269
ARG X 219
LEU X 203
LEU X 206
 None
 0.95A 4xtaB-1gngA:
0.0		 4xtaB-1gngA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
LYS A  85
TYR A 134
CYH A 199
PHE A 201
 None
 1.01A 5hesB-1gngA:
20.1		 5hesB-1gngA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 7 ILE A  62
GLY A  63
LEU A 112
ASP A 200
PHE A 201
 None
 1.12A 5hieB-1gngA:
20.9		 5hieB-1gngA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 8 ILE A  62
GLY A  63
ASP A 200
PHE A 201
 None
 0.75A 5hieD-1gngA:
21.0		 5hieD-1gngA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 8 ILE A 156
PRO A 154
LEU A 189
LEU A 343
 None
 0.86A 5ieoA-1gngA:
0.0		 5ieoA-1gngA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 7 GLY A  63
GLY A  65
SER A  66
GLY A  68
VAL A  70
 None
 0.64A 5izjB-1gngA:
24.9		 5izjB-1gngA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		5 / 7 GLY A  63
GLY A  65
SER A  66
VAL A  70
LYS A  85
 None
 0.72A 5izjA-1gngA:
24.9		 5izjA-1gngA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		6 / 7 GLY A  63
GLY A  65
SER A  66
VAL A  70
LYS A  85
ASP A 200
 None
 0.56A 5j5xA-1gngA:
25.1		 5j5xA-1gngA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		8 / 12 ILE A  62
GLY A  63
VAL A  70
ALA A  83
LYS A  85
GLU A  97
LEU A 132
TYR A 134
 None
 0.57A 5mafA-1gngA:
24.6		 5mafA-1gngA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 4 VAL A  70
LYS A  85
VAL A 110
ASN A 186
 None
 0.88A 5vc3A-1gngA:
24.5		 5vc3A-1gngA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		7 / 12 ALA A  83
LYS A  85
GLU A  97
LEU A 130
LEU A 188
CYH A 199
ASP A 200
 None
 0.95A 5y7zB-1gngA:
16.8		 5y7zB-1gngA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 6 LEU A 169
LEU A 165
TYR A 222
LEU A 320
 None
 1.06A 6f6sA-1gngA:
0.0
6f6sB-1gngA:
0.0		 6f6sA-1gngA:
10.85
6f6sB-1gngA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 6 LEU A 332
ALA A 170
SER A 368
ASN A 361
 None
 0.78A 6f88A-1gngA:
0.0		 6f88A-1gngA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		4 / 6 LEU A 332
ALA A 170
SER A 368
ASN A 361
 None
 0.79A 6f88B-1gngA:
undetectable		 6f88B-1gngA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
LYS A  85
GLU A  97
VAL A 110
LEU A 188
 None
 0.59A 6hd4A-1gngA:
20.4		 6hd4A-1gngA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
LYS A  85
GLU A  97
VAL A 110
LEU A 188
 None
 0.56A 6hd6B-1gngA:
20.4		 6hd6B-1gngA:
12.42