SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 7 ALA A 137
LEU A 135
SER A 130
SER A 132
 None
 0.86A 1dvxA-1gnsA:
undetectable		 1dvxA-1gnsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 11 SER A 125
HIS A  64
LEU A  42
SER A 207
ILE A  35
 CSO  A 221 ( 2.6A)
CSO  A 221 ( 4.3A)
None
None
None
 1.27A 1ee2A-1gnsA:
undetectable		 1ee2A-1gnsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 11 SER A 125
HIS A  64
LEU A  42
SER A 207
ILE A  35
 CSO  A 221 ( 2.6A)
CSO  A 221 ( 4.3A)
None
None
None
 1.30A 1ee2B-1gnsA:
undetectable		 1ee2B-1gnsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 12 TYR A 171
ILE A 107
SER A 173
GLY A 128
TYR A 104
 None
 1.08A 1kiaA-1gnsA:
2.1		 1kiaA-1gnsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 12 TYR A 171
ILE A 107
SER A 173
GLY A 128
TYR A 104
 None
 1.07A 1nbhB-1gnsA:
undetectable		 1nbhB-1gnsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 4 VAL A  30
LEU A 250
ILE A 234
LEU A 233
 None
 1.03A 2byoA-1gnsA:
0.0		 2byoA-1gnsA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 11 ALA A 230
ILE A 175
ILE A 234
ALA A 273
VAL A 198
 None
 1.14A 2qhfA-1gnsA:
0.1		 2qhfA-1gnsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 9 ALA A 151
ALA A 153
SER A 190
SER A 224
ALA A 223
 None
 1.30A 2vh3A-1gnsA:
undetectable		 2vh3A-1gnsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 12 THR A 254
ILE A 268
GLY A 264
GLY A 266
PHE A 261
 None
 1.02A 2yvlA-1gnsA:
2.7		 2yvlA-1gnsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 12 SER A 163
THR A 164
GLY A 169
GLY A 166
LEU A 196
 None
 1.00A 3fzgA-1gnsA:
undetectable		 3fzgA-1gnsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 12 LEU A  90
GLY A  23
VAL A 121
PRO A 225
VAL A  28
 None
None
None
CSO  A 221 ( 4.1A)
None
 1.12A 3gguA-1gnsA:
undetectable		 3gguA-1gnsA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A  70
MET A 222
LEU A  42
ILE A  35
 None
CSO  A 221 ( 3.8A)
None
None
 0.95A 3nbqB-1gnsA:
2.6		 3nbqB-1gnsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 5 GLY A 169
LYS A 170
GLU A 195
GLY A 166
 None
 0.73A 3onnA-1gnsA:
undetectable		 3onnA-1gnsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 10 MET A 124
VAL A 139
TYR A 104
ILE A 107
ILE A 111
 None
 1.14A 3p4wD-1gnsA:
0.0		 3p4wD-1gnsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 10 MET A 124
VAL A 139
TYR A 104
ILE A 107
ILE A 111
 None
 1.14A 3p4wE-1gnsA:
undetectable		 3p4wE-1gnsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		3 / 3 LYS A 222
VAL A  68
HIS A  67
 CSO  A 221 ( 3.2A)
CSO  A 221 ( 4.3A)
None
 0.95A 3tj7A-1gnsA:
0.0		 3tj7A-1gnsA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 6 ASP A  60
ASN A  61
ALA A  98
ASP A  32
 None
 1.08A 4mdbA-1gnsA:
1.4		 4mdbA-1gnsA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 6 MET A 119
ILE A 268
ILE A  11
VAL A 270
 None
 0.90A 4olmA-1gnsA:
0.0		 4olmA-1gnsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 10 VAL A 148
LEU A 250
GLY A  23
ALA A 232
SER A 236
 None
 1.10A 4ph9A-1gnsA:
0.0		 4ph9A-1gnsA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 10 VAL A 148
LEU A 250
GLY A  23
ALA A 232
SER A 236
 None
 1.11A 4ph9B-1gnsA:
0.0		 4ph9B-1gnsA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 8 LEU A 233
VAL A  84
ILE A 268
ALA A 273
LEU A 250
 None
 1.28A 4qrcA-1gnsA:
undetectable		 4qrcA-1gnsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 12 ALA A 151
VAL A 150
GLY A 178
GLU A 156
ALA A 187
 None
 1.15A 5n5dA-1gnsA:
undetectable		 5n5dA-1gnsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 7 GLY A 266
GLY A 264
SER A 224
LEU A 250
THR A 254
 None
 1.06A 5o96C-1gnsA:
2.8		 5o96C-1gnsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 6 PRO A 201
VAL A 177
VAL A 150
ILE A  11
 None
 0.91A 5pbeA-1gnsA:
undetectable		 5pbeA-1gnsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		5 / 11 GLY A 229
ALA A 230
ALA A  85
PRO A  86
VAL A  28
 None
 1.10A 5yk2A-1gnsA:
undetectable		 5yk2A-1gnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 5 ALA A 134
SER A 132
GLY A 131
TYR A 171
 None
 1.15A 5yodB-1gnsA:
0.0		 5yodB-1gnsA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1gns SUBTILISIN BPN'
(Bacillus
amyloliquefacien
s) 		4 / 5 ALA A 134
SER A 132
GLY A 131
TYR A 171
 None
 1.19A 5yodD-1gnsA:
undetectable		 5yodD-1gnsA:
24.15