SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 11 ALA A 175
VAL A 146
LEU A 147
ALA A 144
LEU A 179
 None
 1.02A 1jinA-1gnwA:
1.9		 1jinA-1gnwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 TYR A  78
ILE A   3
TYR A  73
ARG A  77
 None
 1.22A 1qltA-1gnwA:
1.1		 1qltA-1gnwA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 TYR A  78
ILE A   3
TYR A  73
ARG A  77
 None
 1.21A 1qltB-1gnwA:
1.1		 1qltB-1gnwA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 TYR A  78
ILE A   3
TYR A  73
ARG A  77
 None
 1.25A 1vaoA-1gnwA:
1.6		 1vaoA-1gnwA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 TYR A  78
ILE A   3
TYR A  73
ARG A  77
 None
 1.25A 1vaoB-1gnwA:
1.6		 1vaoB-1gnwA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 8 ALA A 114
LEU A 143
LEU A 147
ILE A 176
VAL A 194
 None
 1.36A 2uxpA-1gnwA:
undetectable		 2uxpA-1gnwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 PRO A  55
LEU A  21
ILE A  74
ALA A  75
LEU A 170
 GTX  A 212 (-4.6A)
None
None
None
None
 1.10A 3a50D-1gnwA:
2.6		 3a50D-1gnwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 ARG A  48
PRO A  55
PHE A  45
 None
GTX  A 212 (-4.6A)
None
 1.00A 3thrC-1gnwA:
undetectable		 3thrC-1gnwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 ARG A  16
PRO A  55
GLU A  66
SER A  67
 GTX  A 212 ( 4.8A)
GTX  A 212 (-4.6A)
GTX  A 212 (-2.3A)
GTX  A 212 (-2.7A)
 0.94A 3vlnA-1gnwA:
21.1		 3vlnA-1gnwA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 ASP A 111
LEU A 143
VAL A 135
 None
 0.63A 4jecB-1gnwA:
undetectable		 4jecB-1gnwA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 LYS A 142
LEU A 143
GLU A 139
LEU A 117
 None
 1.19A 4k4yA-1gnwA:
0.0		 4k4yA-1gnwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 4 LYS A 142
LEU A 143
GLU A 139
LEU A 117
 None
 1.22A 4k4yE-1gnwA:
0.0		 4k4yE-1gnwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 LYS A 142
LEU A 143
GLU A 139
LEU A 117
 None
 1.23A 4k4yI-1gnwA:
0.0		 4k4yI-1gnwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 HIS A 172
GLU A 106
SER A 115
PRO A 112
 None
None
GTX  A 213 ( 4.0A)
None
 1.19A 4uhxA-1gnwA:
undetectable		 4uhxA-1gnwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 HIS A 172
GLU A 106
SER A 115
PRO A 112
 None
None
GTX  A 213 ( 4.0A)
None
 1.19A 4uhxA-1gnwA:
undetectable		 4uhxA-1gnwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 ILE A 201
PHE A 165
ILE A  19
GLU A  23
 None
 1.34A 4zzcA-1gnwA:
2.6
4zzcB-1gnwA:
2.8		 4zzcA-1gnwA:
20.89
4zzcB-1gnwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 5 VAL A 198
THR A 202
LEU A 147
VAL A 113
 None
 1.01A 6bqgA-1gnwA:
2.8		 6bqgA-1gnwA:
19.34