SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 12 VAL A 380
GLY A 426
LEU A  23
VAL A 128
PHE A 303
 None
 1.19A 1a27A-1gnxA:
2.3		 1a27A-1gnxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ARG A  56
ILE A  46
TRP A  47
 None
 1.16A 1nodB-1gnxA:
0.0		 1nodB-1gnxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 4 ILE A 459
ASP A  76
LEU A  83
ARG A 445
 None
 1.01A 2a7qA-1gnxA:
1.0		 2a7qA-1gnxA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 7 GLU A 402
LYS A 461
PRO A 401
ALA A 462
 None
 1.36A 2ejgA-1gnxA:
0.0		 2ejgA-1gnxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 12 PHE A 428
LEU A  23
ILE A 125
ALA A  87
THR A 130
 None
 1.17A 2g78A-1gnxA:
0.0		 2g78A-1gnxA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ASP A 164
ASP A 168
ASP A 222
 None
 0.69A 2igtA-1gnxA:
undetectable		 2igtA-1gnxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ASP A 164
ASP A 168
ASP A 222
 None
 0.72A 2igtB-1gnxA:
undetectable		 2igtB-1gnxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ARG A  56
ILE A  46
TRP A  47
 None
 1.13A 2nodB-1gnxA:
0.0		 2nodB-1gnxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 ALA A 386
ASP A 434
ASP A 452
ASP A 400
 None
 1.18A 2nyuB-1gnxA:
undetectable		 2nyuB-1gnxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 11 ASN A 177
GLU A 178
TYR A 309
GLU A 383
TRP A 430
 None
 0.86A 2v3dB-1gnxA:
16.0		 2v3dB-1gnxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 8 LEU A 429
ALA A 448
GLY A  25
LEU A  85
GLY A  84
 None
 1.30A 2yfxA-1gnxA:
undetectable		 2yfxA-1gnxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 7 ALA A 160
ALA A 159
ALA A 163
GLN A 218
 None
None
None
SUC  A 600 (-3.6A)
 0.87A 3a2qA-1gnxA:
0.0		 3a2qA-1gnxA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 THR A 382
THR A 175
HIS A 213
LEU A 301
 None
 1.36A 3ce6A-1gnxA:
undetectable		 3ce6A-1gnxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 4 LEU A 234
ASP A 302
VAL A 380
THR A 382
 None
 1.20A 3cyxB-1gnxA:
undetectable		 3cyxB-1gnxA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ARG A  56
ILE A  46
TRP A  47
 None
 1.10A 3e7iB-1gnxA:
0.0		 3e7iB-1gnxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ARG A  56
ILE A  46
TRP A  47
 None
 1.05A 3nw2B-1gnxA:
0.0		 3nw2B-1gnxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 TYR A  70
ASP A  68
ASP A  64
 None
 0.93A 3ou7B-1gnxA:
undetectable		 3ou7B-1gnxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 12 ALA A  87
GLY A 426
ILE A 381
THR A 174
VAL A 128
 None
 0.91A 3so9B-1gnxA:
undetectable		 3so9B-1gnxA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 6 LEU A 176
HIS A 213
THR A 233
ARG A  89
 None
 1.30A 3thrB-1gnxA:
1.0		 3thrB-1gnxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 PHE A 184
LEU A 276
THR A 284
VAL A 200
 None
 0.99A 3wrkD-1gnxA:
0.0		 3wrkD-1gnxA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 THR A 382
THR A 175
HIS A 213
LEU A 301
 None
 1.31A 4lvcA-1gnxA:
undetectable		 4lvcA-1gnxA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 THR A 382
THR A 175
HIS A 213
LEU A 301
 None
 1.31A 4lvcC-1gnxA:
undetectable		 4lvcC-1gnxA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 ASN A 177
PHE A 428
TYR A  88
 None
 0.60A 4u15A-1gnxA:
undetectable		 4u15A-1gnxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 LEU A 366
ALA A 413
VAL A 424
ILE A 418
 None
 0.86A 4xe3A-1gnxA:
0.0		 4xe3A-1gnxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 11 LEU A  83
SER A 431
LEU A 429
ARG A 403
SER A 463
 None
 1.22A 4zbqA-1gnxA:
0.0		 4zbqA-1gnxA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 SER A 310
TYR A 309
TYR A 308
 None
 0.78A 5lakA-1gnxA:
0.0
5lakI-1gnxA:
undetectable		 5lakA-1gnxA:
20.35
5lakI-1gnxA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 SER A 310
TYR A 309
TYR A 308
 None
 0.69A 5lakC-1gnxA:
0.0
5lakJ-1gnxA:
undetectable		 5lakC-1gnxA:
20.35
5lakJ-1gnxA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 HIS A 207
HIS A 208
ARG A 204
 None
None
SO4  A 610 (-2.8A)
 1.13A 6b58A-1gnxA:
undetectable		 6b58A-1gnxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 8 LEU A 136
GLU A 139
THR A 151
TRP A  94
 None
 1.21A 6c71B-1gnxA:
undetectable		 6c71B-1gnxA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		5 / 12 GLY A 190
GLY A 282
THR A 284
LEU A 203
THR A 197
 None
 1.16A 6e8qA-1gnxA:
0.0		 6e8qA-1gnxA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		3 / 3 LEU A 377
ASN A 307
LEU A 367
 None
 0.64A 6exiA-1gnxA:
undetectable		 6exiA-1gnxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 ARG A  52
ALA A  51
GLN A 138
ILE A  46
 None
 1.44A 6g9bA-1gnxA:
0.0
6g9bB-1gnxA:
0.0		 6g9bA-1gnxA:
14.16
6g9bB-1gnxA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 THR A 382
THR A 175
HIS A 213
LEU A 301
 None
 1.33A 6gbnA-1gnxA:
undetectable		 6gbnA-1gnxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 5 THR A 382
THR A 175
HIS A 213
LEU A 301
 None
 1.33A 6gbnD-1gnxA:
undetectable		 6gbnD-1gnxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gnx BETA-GLUCOSIDASE
(Streptomyces
sp.) 		4 / 7 ASP A  68
THR A  67
TYR A 453
HIS A 133
 None
 1.29A 6nmfN-1gnxA:
0.1
6nmfP-1gnxA:
0.3		 6nmfN-1gnxA:
22.40
6nmfP-1gnxA:
20.00