SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 12 SER A 151
ILE A 152
LEU A 108
GLY A 109
PHE A 111
 None
 1.13A 1tlsA-1gnzA:
0.0		 1tlsA-1gnzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 12 SER A 151
ILE A 152
LEU A 108
GLY A 109
PHE A 111
 None
 1.13A 1tlsB-1gnzA:
0.0		 1tlsB-1gnzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 4 VAL A 187
ASP A 164
LEU A  79
ARG A 174
 None
None
None
PO4  A1241 (-4.0A)
 1.46A 2ziaA-1gnzA:
undetectable		 2ziaA-1gnzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 12 LEU A 110
SER A 217
VAL A 149
LEU A 184
LEU A  60
 None
 1.37A 2zlcA-1gnzA:
undetectable		 2zlcA-1gnzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 12 LEU A 226
LEU A 108
PHE A 129
LEU A 188
TYR A 190
 None
 1.45A 3adsA-1gnzA:
undetectable		 3adsA-1gnzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 8 LEU A 108
GLY A  24
ALA A  26
ILE A 230
 None
 0.75A 3jusA-1gnzA:
0.0		 3jusA-1gnzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 8 LEU A 108
GLY A  24
ALA A  26
ILE A 230
 None
 0.75A 3jusA-1gnzA:
0.0		 3jusA-1gnzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 8 LEU A 108
GLY A  24
ALA A  26
ILE A 230
 None
 0.80A 3jusB-1gnzA:
undetectable		 3jusB-1gnzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 6 HIS A 144
VAL A 186
ILE A 152
LEU A 184
 None
 0.66A 3kk6A-1gnzA:
undetectable		 3kk6A-1gnzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 12 GLY A 215
ILE A 175
VAL A 186
ASN A 148
LEU A  90
 None
 1.21A 4a81A-1gnzA:
0.0		 4a81A-1gnzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		3 / 3 PHE A  77
TYR A 196
TYR A 190
 None
 1.05A 4ffwA-1gnzA:
1.6		 4ffwA-1gnzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 9 THR A 227
ALA A 218
ILE A 216
CYH A  36
ILE A 230
 None
 1.06A 4lbgB-1gnzA:
undetectable		 4lbgB-1gnzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 5 ILE A 152
ARG A  51
GLU A 128
VAL A 155
 None
 1.27A 4nkxD-1gnzA:
undetectable		 4nkxD-1gnzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 8 ILE A 145
PHE A  77
LEU A 188
LEU A  79
 None
 0.86A 4qopC-1gnzA:
undetectable		 4qopC-1gnzA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 9 SER A 219
ALA A  49
LEU A 110
ILE A 216
 None
 0.83A 4xtaA-1gnzA:
undetectable		 4xtaA-1gnzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 9 ALA A  52
GLN A  23
PHE A  22
LEU A  33
PHE A   9
 None
 1.41A 5i73A-1gnzA:
undetectable		 5i73A-1gnzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		4 / 6 VAL A 124
LEU A  90
SER A 217
ILE A 230
 None
 1.04A 5jw1A-1gnzA:
undetectable		 5jw1A-1gnzA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		3 / 3 TRP A  61
MET A 204
ASN A 207
 None
 1.43A 5uc1B-1gnzA:
undetectable		 5uc1B-1gnzA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		3 / 3 TRP A  61
MET A 204
ASN A 207
 None
 1.41A 5uc1A-1gnzA:
undetectable		 5uc1A-1gnzA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gnz GSI-B4 ISOLECTIN
(Griffonia
simplicifolia) 		5 / 8 LEU A  35
VAL A 228
ILE A 216
GLY A 215
ILE A 145
 None
 1.22A 5vkqB-1gnzA:
undetectable
5vkqC-1gnzA:
undetectable		 5vkqB-1gnzA:
9.98
5vkqC-1gnzA:
9.98