SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gpj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		5 / 9 VAL A  88
LEU A  45
ILE A 131
ALA A 130
LEU A  85
 None
 1.12A 1eqgA-1gpjA:
0.0		 1eqgA-1gpjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		5 / 11 VAL A  88
LEU A  45
ILE A 131
ALA A 130
LEU A  85
 None
 1.14A 1eqgB-1gpjA:
0.0		 1eqgB-1gpjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		4 / 6 HIS A  70
ILE A  69
ALA A  62
VAL A  53
 None
 0.85A 1hk1A-1gpjA:
2.4		 1hk1A-1gpjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		4 / 6 LEU A 330
ASP A 386
ASP A   3
GLU A 323
 None
 1.17A 2j2pE-1gpjA:
0.0
2j2pF-1gpjA:
0.0		 2j2pE-1gpjA:
18.95
2j2pF-1gpjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 VAL A 244
ASP A 245
GLU A 272
 None
 0.56A 2qeuA-1gpjA:
0.3		 2qeuA-1gpjA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 VAL A 244
ASP A 245
GLU A 272
 None
 0.58A 2qeuC-1gpjA:
0.0		 2qeuC-1gpjA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		4 / 4 TYR A  54
LEU A  44
LEU A  45
HIS A  84
 None
 1.38A 2x7hB-1gpjA:
9.0		 2x7hB-1gpjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 LEU A 289
ARG A 284
ILE A 286
 None
 0.59A 2xn5B-1gpjA:
0.0		 2xn5B-1gpjA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 THR A 169
SER A 228
ARG A 227
 None
 0.78A 3phnA-1gpjA:
0.0		 3phnA-1gpjA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		4 / 4 ASN A 198
ALA A 175
GLY A 174
THR A 235
 None
 1.39A 4bboC-1gpjA:
undetectable		 4bboC-1gpjA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		4 / 6 SER A 393
GLU A 401
ASP A 343
ASP A 333
 None
 1.14A 4blvA-1gpjA:
4.7		 4blvA-1gpjA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 GLY A 134
ILE A 143
SER A 144
ILE A 131
ALA A  89
 None
 1.14A 4qtuB-1gpjA:
5.5		 4qtuB-1gpjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 GLY A 134
ILE A 143
SER A 144
ILE A 131
ALA A  89
 None
 1.10A 4qtuD-1gpjA:
5.0		 4qtuD-1gpjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 VAL A  53
SER A   6
SER A  42
PHE A 127
VAL A  88
 None
 1.10A 6a94B-1gpjA:
undetectable		 6a94B-1gpjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1gpj GLUTAMYL-TRNA
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 VAL A 230
GLY A 151
LEU A 261
VAL A 172
VAL A 170
 None
 1.07A 6dh0B-1gpjA:
undetectable		 6dh0B-1gpjA:
10.62