SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		6 / 9 ASP A 195
ILE A 148
VAL A 128
GLY A 125
ILE A 121
ILE A 172
 CA  A 500 (-2.3A)
None
None
None
None
None
 1.50A 1hshB-1gplA:
undetectable		 1hshB-1gplA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 8 TRP A  85
GLY A  76
SER A 152
HIS A 263
 None
 1.02A 1maaD-1gplA:
9.5		 1maaD-1gplA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 5 PHE A  11
ARG A 164
ILE A  34
GLU A 127
 None
 1.38A 1oniG-1gplA:
0.8
1oniH-1gplA:
0.7		 1oniG-1gplA:
16.67
1oniH-1gplA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		3 / 3 ILE A 148
ILE A  74
THR A  70
 None
 0.64A 1rg7A-1gplA:
undetectable		 1rg7A-1gplA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 TYR A 270
GLY A 174
ALA A 196
ILE A  74
HIS A 147
 None
 1.10A 1ve3A-1gplA:
undetectable		 1ve3A-1gplA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 7 TRP A  85
GLY A  76
SER A 152
HIS A 263
 None
 1.16A 2ackA-1gplA:
10.7		 2ackA-1gplA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		3 / 3 ALA A 155
GLY A 216
SER A 266
 None
 0.45A 2ivuA-1gplA:
0.3		 2ivuA-1gplA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 10 SER A  62
ILE A  52
ILE A 102
LEU A 131
VAL A 146
 None
 1.25A 2nnhB-1gplA:
0.0		 2nnhB-1gplA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 5 VAL A 422
VAL A 392
ASP A 391
SER A 388
 None
 1.27A 2x45C-1gplA:
0.0		 2x45C-1gplA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 6 ASN A 100
ARG A  68
ASN A  63
GLU A  44
 None
 1.22A 3galA-1gplA:
undetectable		 3galA-1gplA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 10 ALA A 161
VAL A 124
GLY A 150
ILE A 149
VAL A 128
 None
 0.96A 3t3cB-1gplA:
undetectable		 3t3cB-1gplA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 7 PHE A 386
TYR A 340
VAL A 342
ILE A 420
 None
 0.89A 4a97H-1gplA:
undetectable		 4a97H-1gplA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 GLN A 133
GLY A 162
ALA A 129
ILE A 172
LEU A 168
 None
 1.25A 4azsA-1gplA:
undetectable		 4azsA-1gplA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 GLN A 133
GLY A 162
ALA A 129
ILE A 172
LEU A 168
 None
 1.23A 4azwA-1gplA:
undetectable		 4azwA-1gplA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 7 ILE A 149
ARG A 171
ALA A 158
GLN A 323
 None
 0.93A 4g0uB-1gplA:
2.4		 4g0uB-1gplA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 7 PHE A 198
PRO A 305
TYR A 314
PHE A 226
 None
 1.39A 4grqA-1gplA:
0.0
4grqC-1gplA:
0.0		 4grqA-1gplA:
13.67
4grqC-1gplA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 GLU A 160
VAL A 123
PRO A  29
THR A  20
GLY A  19
 None
 1.47A 4hvcA-1gplA:
undetectable		 4hvcA-1gplA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 TYR A 114
GLY A  76
ILE A 121
ILE A  74
SER A 152
 None
 0.94A 4iv0A-1gplA:
2.0		 4iv0A-1gplA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 TYR A 114
GLY A  76
ILE A 121
ILE A  74
SER A 152
 None
 0.99A 4iv0B-1gplA:
undetectable		 4iv0B-1gplA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		3 / 3 HIS A 151
TRP A 106
SER A 266
 None
 1.17A 4lrhD-1gplA:
0.0		 4lrhD-1gplA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 TYR A 114
GLY A  76
ILE A 121
ILE A  74
SER A 152
 None
 0.99A 4mwzA-1gplA:
undetectable		 4mwzA-1gplA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 TYR A 114
GLY A  76
ILE A 121
ILE A  74
SER A 152
 None
 0.92A 4mwzB-1gplA:
undetectable		 4mwzB-1gplA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		5 / 12 GLU A 160
VAL A 123
PRO A  29
THR A  20
GLY A  19
 None
 1.47A 4olfA-1gplA:
undetectable		 4olfA-1gplA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		3 / 3 GLU A 278
LYS A 306
ASN A 276
 None
 1.08A 4y1dA-1gplA:
0.0
4y1dD-1gplA:
undetectable		 4y1dA-1gplA:
16.86
4y1dD-1gplA:
1.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		3 / 3 THR A 204
SER A 266
TYR A 269
 None
 0.89A 5jsdB-1gplA:
0.3		 5jsdB-1gplA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 5 HIS A 263
ALA A 178
SER A 152
GLY A  76
 None
 1.25A 5yodD-1gplA:
undetectable		 5yodD-1gplA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1gpl RP2 LIPASE
(Cavia
porcellus) 		4 / 6 GLU A  14
TRP A  17
ALA A  18
GLN A 119
 None
 1.29A 6f6jC-1gplA:
0.0
6f6jD-1gplA:
0.0		 6f6jC-1gplA:
20.00
6f6jD-1gplA:
20.00