SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 6 LEU A 393
MET A 276
LEU A 283
HIS A 280
 None
 1.21A 1errB-1gpmA:
0.0		 1errB-1gpmA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 283
PHE A 277
LEU A 255
PRO A 375
VAL A 373
 None
 1.10A 1hrkA-1gpmA:
2.4		 1hrkA-1gpmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 8 TRP A  37
TYR A  33
TRP A 208
TYR A 338
 None
 1.03A 1maaD-1gpmA:
2.5		 1maaD-1gpmA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 ILE A  54
GLY A  53
PHE A  49
ASN A  50
 None
 0.87A 1oniG-1gpmA:
0.7
1oniI-1gpmA:
0.0		 1oniG-1gpmA:
13.70
1oniI-1gpmA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 379
LEU A 376
LEU A 247
LEU A 391
ILE A 213
 None
 1.15A 1s9pD-1gpmA:
undetectable		 1s9pD-1gpmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 THR A 449
LEU A 472
VAL A 496
VAL A 504
 None
 1.07A 1t87A-1gpmA:
0.0		 1t87A-1gpmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.82A 2avvD-1gpmA:
undetectable		 2avvD-1gpmA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 9 GLU A 378
LEU A 391
LEU A 246
ARG A 220
ALA A 219
 None
 1.38A 2bxcB-1gpmA:
undetectable		 2bxcB-1gpmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 8 TRP A  37
TYR A  33
TRP A 208
TYR A 338
 None
 1.10A 2ha2A-1gpmA:
undetectable		 2ha2A-1gpmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 8 TRP A  37
TYR A  33
TRP A 208
TYR A 338
 None
 1.09A 2ha2B-1gpmA:
undetectable		 2ha2B-1gpmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.89A 2o4lB-1gpmA:
undetectable		 2o4lB-1gpmA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.84A 2q63A-1gpmA:
undetectable		 2q63A-1gpmA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.87A 2qakA-1gpmA:
undetectable		 2qakA-1gpmA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 6 TRP A  37
TYR A  33
TRP A 208
TYR A 338
 None
 1.11A 2xudA-1gpmA:
1.0		 2xudA-1gpmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 6 THR A 449
LEU A 472
VAL A 496
VAL A 504
 None
 1.06A 2zuiA-1gpmA:
0.0		 2zuiA-1gpmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 122
PHE A  83
ARG A 199
PRO A 182
LEU A 194
 None
 1.27A 3j6pB-1gpmA:
2.0		 3j6pB-1gpmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 GLY A 312
CYH A 421
GLY A 405
PHE A 403
 None
None
AMP  A 527 ( 3.7A)
None
 0.93A 3ko0M-1gpmA:
undetectable
3ko0P-1gpmA:
undetectable		 3ko0M-1gpmA:
11.11
3ko0P-1gpmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 6 VAL A  82
ILE A  46
MET A  92
ARG A  28
 None
 1.13A 3ms9A-1gpmA:
undetectable		 3ms9A-1gpmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 VAL A  82
ILE A  46
MET A  92
ARG A  28
 None
 1.06A 3ms9B-1gpmA:
undetectable		 3ms9B-1gpmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 6 VAL A  82
ILE A  46
MET A  92
ARG A  28
 None
 1.13A 3mssA-1gpmA:
undetectable		 3mssA-1gpmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 PHE A 448
VAL A 475
ARG A 308
VAL A 410
ARG A 411
 None
 1.25A 3p6gA-1gpmA:
undetectable		 3p6gA-1gpmA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 8 PHE A 259
ASN A 262
LEU A 265
PHE A 403
 None
AMP  A 527 ( 4.8A)
None
None
 0.99A 3rqwC-1gpmA:
undetectable
3rqwD-1gpmA:
undetectable		 3rqwC-1gpmA:
19.40
3rqwD-1gpmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 8 PHE A 259
ASN A 262
LEU A 265
PHE A 403
 None
AMP  A 527 ( 4.8A)
None
None
 0.97A 3rqwI-1gpmA:
0.0
3rqwJ-1gpmA:
0.0		 3rqwI-1gpmA:
19.40
3rqwJ-1gpmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 8 LEU A 265
PHE A 403
PHE A 259
ASN A 262
 None
None
None
AMP  A 527 ( 4.8A)
 0.96A 3rqwF-1gpmA:
0.2
3rqwJ-1gpmA:
0.0		 3rqwF-1gpmA:
19.40
3rqwJ-1gpmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 THR A 449
LEU A 472
VAL A 496
VAL A 504
 None
 1.05A 4l4gA-1gpmA:
0.0		 4l4gA-1gpmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 5 PHE A 281
PHE A 277
LEU A 247
PRO A 375
 None
 1.43A 4o8zA-1gpmA:
3.6		 4o8zA-1gpmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 6 ILE A  54
VAL A  23
PHE A 197
ARG A 174
 None
 0.88A 4xe5A-1gpmA:
2.6		 4xe5A-1gpmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 GLY A  88
VAL A 100
ASP A 145
VAL A 147
 None
 0.80A 5ik1A-1gpmA:
undetectable		 5ik1A-1gpmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 7 LEU A 379
ILE A 387
GLY A 388
LEU A 391
ILE A 251
 None
 1.35A 5vkqA-1gpmA:
0.0
5vkqB-1gpmA:
0.0		 5vkqA-1gpmA:
16.11
5vkqB-1gpmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		3 / 3 GLN A 224
TRP A 331
VAL A 230
 None
 0.64A 6auuA-1gpmA:
0.0		 6auuA-1gpmA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		4 / 7 VAL A 273
LEU A 423
PHE A 403
LEU A 408
 None
 1.04A 6aycA-1gpmA:
0.0		 6aycA-1gpmA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 10 GLU A 476
SER A 471
VAL A 496
PHE A 431
PHE A 492
 None
 1.12A 6behA-1gpmA:
0.0
6behB-1gpmA:
0.0
6behC-1gpmA:
0.0		 6behA-1gpmA:
22.10
6behB-1gpmA:
22.10
6behC-1gpmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 393
GLY A 237
VAL A 384
ILE A 337
GLY A 335
 None
POP  A 526 (-3.4A)
None
None
None
 0.85A 6dilB-1gpmA:
undetectable		 6dilB-1gpmA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A 400
HIS A 401
ARG A 436
 None
 1.15A 6dwdD-1gpmA:
0.0		 6dwdD-1gpmA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1gpm GMP SYNTHETASE
(Escherichia
coli) 		5 / 9 ILE A 311
GLY A 407
LEU A 408
GLY A 236
ASN A 262
 None
None
None
None
AMP  A 527 ( 4.8A)
 1.26A 6nm4B-1gpmA:
0.0		 6nm4B-1gpmA:
16.73