SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 425
ARG A 118
ASP A 163
LEU A 166
 None
 1.28A 1n13B-1gppA:
0.0
1n13C-1gppA:
0.0		 1n13B-1gppA:
15.90
1n13C-1gppA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  87
GLU A 121
SER A  88
 None
 0.77A 2xkkA-1gppA:
undetectable
2xkkC-1gppA:
undetectable		 2xkkA-1gppA:
15.24
2xkkC-1gppA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 THR A   6
PHE A 444
VAL A 451
VAL A  27
VAL A  83
 None
 1.09A 3dl9A-1gppA:
undetectable		 3dl9A-1gppA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  21
HIS A 442
VAL A  82
PHE A   2
 None
 0.83A 4a97H-1gppA:
undetectable		 4a97H-1gppA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  11
ILE A 434
LEU A 445
VAL A   8
ILE A  18
 None
 1.09A 4aztA-1gppA:
undetectable		 4aztA-1gppA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  50
LEU A  81
VAL A  83
PHE A 421
 None
 1.00A 4lb0B-1gppA:
0.0		 4lb0B-1gppA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 448
VAL A 452
THR A   6
ILE A  18
 None
 1.47A 4retA-1gppA:
undetectable		 4retA-1gppA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 448
VAL A 452
THR A   6
ILE A  18
 None
 1.47A 4retC-1gppA:
0.0		 4retC-1gppA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  11
ILE A 434
LEU A 445
VAL A   8
ILE A  18
 None
 1.07A 4uw0A-1gppA:
undetectable		 4uw0A-1gppA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 450
LEU A 446
VAL A 452
 None
 0.63A 4wq4A-1gppA:
undetectable		 4wq4A-1gppA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  -1
ILE A 434
GLY A  29
PHE A 444
SER A 437
 None
 1.23A 5i6xA-1gppA:
undetectable		 5i6xA-1gppA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  -1
ILE A 434
PHE A 444
SER A 437
VAL A   8
 None
 1.02A 5i6xA-1gppA:
undetectable		 5i6xA-1gppA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1gpp ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 167
GLY A 168
VAL A 171
PHE A 155
VAL A 120
 None
 0.99A 5xv7A-1gppA:
undetectable		 5xv7A-1gppA:
16.03