SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 8 HIS A 485
SER A 637
VAL A 657
GLY A 668
 None
 0.34A 1aq7A-1gpzA:
26.6		 1aq7A-1gpzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 12 HIS A 485
SER A 637
VAL A 657
GLY A 660
GLY A 668
 None
 0.83A 1etrH-1gpzA:
27.2		 1etrH-1gpzA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 10 PHE A 621
LEU A 572
VAL A 643
PHE A 641
VAL A 597
 None
 1.46A 1q23K-1gpzA:
0.0		 1q23K-1gpzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 11 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
FUC  A2003 (-3.4A)
None
None
None
 1.27A 1tcoC-1gpzA:
undetectable		 1tcoC-1gpzA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 10 TYR A 529
HIS A 526
ALA A 484
ALA A 542
TYR A 676
 None
 1.39A 2r2vC-1gpzA:
undetectable
2r2vF-1gpzA:
undetectable
2r2vG-1gpzA:
0.0		 2r2vC-1gpzA:
6.77
2r2vF-1gpzA:
6.77
2r2vG-1gpzA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 8 PHE A 317
THR A 297
LEU A 298
ALA A 319
 None
 0.93A 3hrdA-1gpzA:
0.0
3hrdB-1gpzA:
undetectable		 3hrdA-1gpzA:
20.34
3hrdB-1gpzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		5 / 11 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
FUC  A2003 (-3.4A)
None
None
None
 1.12A 3o5rA-1gpzA:
undetectable		 3o5rA-1gpzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.45A 4f3tA-1gpzA:
0.0		 4f3tA-1gpzA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 5 GLY A 472
LEU A 546
LEU A 556
LEU A 561
 None
 0.85A 4o8fA-1gpzA:
undetectable		 4o8fA-1gpzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.41A 4w5qA-1gpzA:
0.0		 4w5qA-1gpzA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.46A 4w5rA-1gpzA:
0.0		 4w5rA-1gpzA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.46A 4w5tA-1gpzA:
0.0		 4w5tA-1gpzA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		3 / 3 ALA A 642
TRP A 651
VAL A 652
 None
 0.31A 4w9nC-1gpzA:
0.0		 4w9nC-1gpzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.44A 4z4gA-1gpzA:
0.0		 4z4gA-1gpzA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 8 SER A 577
GLY A 578
GLY A 470
PHE A 579
 None
 0.88A 5albL-1gpzA:
undetectable		 5albL-1gpzA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.44A 5ki6A-1gpzA:
0.0		 5ki6A-1gpzA:
17.72