SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gq2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 8 ILE A 442
ASN A 411
GLY A 441
LEU A 433
 None
 0.84A 1dzmA-1gq2A:
undetectable		 1dzmA-1gq2A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 9 ILE A 442
VAL A 381
ASN A 411
GLY A 441
LEU A 433
 None
 1.14A 1dzmB-1gq2A:
0.0		 1dzmB-1gq2A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 THR A 283
GLY A 391
GLY A 311
ILE A 319
ALA A 394
 NAP  A1581 (-3.9A)
None
NAP  A1581 (-3.4A)
None
NAP  A1581 (-3.0A)
 1.05A 1nv8B-1gq2A:
3.1		 1nv8B-1gq2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 ALA A 540
ALA A 531
GLY A 482
LEU A 476
GLN A 556
 None
 1.23A 1qabF-1gq2A:
0.0		 1qabF-1gq2A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 7 LEU A 419
VAL A 392
GLY A 391
VAL A 307
 NAP  A1581 (-4.4A)
NAP  A1581 (-4.3A)
None
None
 0.96A 1t88A-1gq2A:
0.0		 1t88A-1gq2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 ILE A 530
ALA A 534
LEU A 549
ILE A 553
ALA A 540
 None
 0.91A 2aclG-1gq2A:
undetectable		 2aclG-1gq2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 PRO A 195
GLY A 182
PHE A  96
THR A 188
TYR A  97
 None
 1.33A 2axnA-1gq2A:
3.1		 2axnA-1gq2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 11 ASN A 537
GLY A 487
ASP A 489
ILE A 530
THR A 539
 None
 1.47A 2f9wA-1gq2A:
2.5
2f9wB-1gq2A:
2.4		 2f9wA-1gq2A:
19.06
2f9wB-1gq2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 ASN A 466
VAL A 286
ALA A 289
VAL A 502
VAL A 522
 OXL  A1583 ( 3.4A)
None
None
None
None
 1.24A 2nniA-1gq2A:
0.0		 2nniA-1gq2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 8 LEU A 251
ARG A 270
LEU A 266
GLY A 282
 None
 0.89A 2po5B-1gq2A:
1.8		 2po5B-1gq2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		3 / 3 LEU A 454
PRO A 455
ARG A 440
 None
 0.46A 2qd4B-1gq2A:
3.8		 2qd4B-1gq2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 7 ILE A 226
ARG A 227
TYR A 231
GLU A 164
 None
 1.03A 2qebA-1gq2A:
0.0		 2qebA-1gq2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 7 ILE A 226
ARG A 227
TYR A 231
GLU A 164
 None
 1.01A 2qebB-1gq2A:
0.0		 2qebB-1gq2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1gq2 MALIC ENZYME
(Columba
livia) 		3 / 3 ARG A 165
GLU A 361
SER A 420
 OXL  A1583 ( 2.8A)
None
NAP  A1581 ( 3.9A)
 0.74A 2xkkA-1gq2A:
4.1
2xkkC-1gq2A:
3.7		 2xkkA-1gq2A:
22.38
2xkkC-1gq2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 6 LEU A  95
GLY A  37
LEU A  88
SER A  87
 None
 0.94A 3aiaA-1gq2A:
2.1		 3aiaA-1gq2A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 10 LEU A 483
ASN A 537
GLY A 487
ASP A 489
ILE A 530
 None
 1.46A 3bexC-1gq2A:
2.3
3bexD-1gq2A:
0.0		 3bexC-1gq2A:
18.38
3bexD-1gq2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 10 ASN A 537
GLY A 487
ASP A 489
ILE A 530
LEU A 483
 None
 1.45A 3bexE-1gq2A:
2.4
3bexF-1gq2A:
2.4		 3bexE-1gq2A:
18.38
3bexF-1gq2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 LEU A 221
LEU A 234
GLY A 141
VAL A 160
MET A 202
 None
 1.03A 3c6gA-1gq2A:
undetectable		 3c6gA-1gq2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 7 PHE A 491
VAL A 474
VAL A 478
LEU A 483
 None
 0.88A 3hs6B-1gq2A:
undetectable		 3hs6B-1gq2A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 GLU A 361
PRO A 360
GLY A 313
ARG A 165
ASN A 261
 None
None
NAP  A1581 (-3.3A)
OXL  A1583 ( 2.8A)
None
 1.43A 3jb2A-1gq2A:
0.0		 3jb2A-1gq2A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gq2 MALIC ENZYME
(Columba
livia) 		3 / 3 ALA A 260
ARG A 264
LYS A 268
 None
 0.97A 3kp5B-1gq2A:
0.0		 3kp5B-1gq2A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 GLY A 163
ASP A 256
GLY A 206
GLY A 170
LEU A 212
 None
MN  A1584 ( 2.5A)
None
None
None
 1.19A 3ku1G-1gq2A:
undetectable		 3ku1G-1gq2A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 GLY A 192
GLY A 477
ALA A 475
SER A 285
ASP A 278
 None
None
None
None
OXL  A1583 ( 4.6A)
 0.93A 3sudD-1gq2A:
undetectable		 3sudD-1gq2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 ILE A 319
LEU A 291
GLY A 446
ASN A 421
VAL A 286
 None
None
NAP  A1581 (-3.3A)
NAP  A1581 ( 3.9A)
None
 1.05A 3uq6B-1gq2A:
undetectable		 3uq6B-1gq2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		3 / 3 ARG A 413
ARG A 440
ILE A 297
 None
 0.92A 4b7qA-1gq2A:
undetectable		 4b7qA-1gq2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		3 / 3 ARG A 413
ARG A 440
ILE A 297
 None
 0.83A 4b7qC-1gq2A:
undetectable		 4b7qC-1gq2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 6 PHE A 309
ALA A 316
ALA A 284
THR A 283
 None
None
None
NAP  A1581 (-3.9A)
 1.02A 4dtzA-1gq2A:
0.0		 4dtzA-1gq2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 6 PHE A 309
ALA A 316
ALA A 284
THR A 283
 None
None
None
NAP  A1581 (-3.9A)
 1.04A 4dtzB-1gq2A:
0.0		 4dtzB-1gq2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 5 ARG A 165
VAL A 392
LEU A 419
SER A 420
 OXL  A1583 ( 2.8A)
NAP  A1581 (-4.3A)
NAP  A1581 (-4.4A)
NAP  A1581 ( 3.9A)
 1.26A 4e1gA-1gq2A:
0.0		 4e1gA-1gq2A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 ILE A 530
ALA A 534
ILE A 553
LEU A 483
ALA A 540
 None
 0.98A 4k6iA-1gq2A:
undetectable		 4k6iA-1gq2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 8 ALA A 289
VAL A 470
GLY A 465
VAL A 522
ILE A 498
 None
 1.30A 4ll3A-1gq2A:
undetectable		 4ll3A-1gq2A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 7 VAL A 201
ARG A 245
ILE A 143
ALA A 241
 None
 0.87A 4lv9A-1gq2A:
undetectable		 4lv9A-1gq2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 7 VAL A 201
ARG A 245
ILE A 143
ALA A 241
 None
 0.89A 4lv9B-1gq2A:
2.7		 4lv9B-1gq2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 8 TYR A 187
PHE A 471
PHE A 276
ILE A 166
 None
 1.00A 4qoiA-1gq2A:
3.5
4qoiB-1gq2A:
2.1		 4qoiA-1gq2A:
19.03
4qoiB-1gq2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 6 ALA A 289
SER A 285
SER A 468
PRO A 514
 None
 1.09A 5c6pA-1gq2A:
0.0		 5c6pA-1gq2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 9 LEU A 291
LEU A 302
ALA A 284
MET A 325
ALA A 326
 None
 1.49A 5g44A-1gq2A:
0.0		 5g44A-1gq2A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 5 TYR A 246
SER A 244
ALA A 241
GLN A 148
 None
 1.30A 5n0wB-1gq2A:
2.2		 5n0wB-1gq2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 5 TYR A 246
SER A 244
ALA A 241
GLN A 148
 None
 1.31A 5n4iA-1gq2A:
1.0		 5n4iA-1gq2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 ILE A 530
ALA A 534
ILE A 553
LEU A 483
ALA A 540
 None
 1.00A 6a5zD-1gq2A:
undetectable		 6a5zD-1gq2A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1gq2 MALIC ENZYME
(Columba
livia) 		5 / 12 LEU A 266
SER A 285
THR A 494
VAL A 470
LEU A 317
 None
 1.39A 6djzB-1gq2A:
0.1		 6djzB-1gq2A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 5 PHE A 254
VAL A 478
MET A 239
VAL A 160
 None
 0.85A 6ekzA-1gq2A:
0.0		 6ekzA-1gq2A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1gq2 MALIC ENZYME
(Columba
livia) 		4 / 6 ARG A 165
GLU A 314
ASP A 279
GLU A 255
 OXL  A1583 ( 2.8A)
NAP  A1581 (-3.3A)
MN  A1584 ( 3.1A)
MN  A1584 ( 3.3A)
 1.44A 6mn5D-1gq2A:
1.3		 6mn5D-1gq2A:
10.52