SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 12 LEU A  59
LEU A  17
CYH A  16
ILE A  79
TYR A  24
 None
 1.43A 4a79A-1gq4A:
undetectable		 4a79A-1gq4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 11 LEU A  59
LEU A  17
CYH A  16
ILE A  79
TYR A  24
 None
 1.45A 4a7aA-1gq4A:
undetectable		 4a7aA-1gq4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 11 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.34A 4c5lA-1gq4A:
undetectable		 4c5lA-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 9 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.32A 4c5lB-1gq4A:
undetectable		 4c5lB-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 10 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.29A 4c5lC-1gq4A:
undetectable		 4c5lC-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 10 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.32A 4c5lD-1gq4A:
undetectable		 4c5lD-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 10 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.25A 4c5nB-1gq4A:
undetectable		 4c5nB-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 10 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.22A 4c5nD-1gq4A:
undetectable		 4c5nD-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		4 / 7 ARG A  80
GLY A  23
GLY A  25
GLU A  43
 None
 0.82A 4koeA-1gq4A:
undetectable
4koeB-1gq4A:
undetectable
4koeD-1gq4A:
undetectable		 4koeA-1gq4A:
12.27
4koeB-1gq4A:
12.27
4koeD-1gq4A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		4 / 7 ARG A  80
GLY A  23
GLY A  25
GLU A  43
 None
 0.83A 4z53A-1gq4A:
undetectable
4z53B-1gq4A:
undetectable		 4z53A-1gq4A:
8.57
4z53B-1gq4A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 12 ILE A  39
VAL A  90
LEU A  59
VAL A  62
ILE A  79
 None
 0.98A 5mueA-1gq4A:
undetectable		 5mueA-1gq4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens) 		5 / 12 ILE A  39
VAL A  90
LEU A  59
VAL A  62
ILE A  79
 None
 0.96A 5mugA-1gq4A:
undetectable		 5mugA-1gq4A:
17.18