SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		3 / 3 THR A 149
THR A 162
PRO A 151
 None
 0.88A 1a7yB-1gq7A:
undetectable		 1a7yB-1gq7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		4 / 8 ALA A 244
ILE A 292
VAL A 277
ILE A 236
 None
 0.66A 1d4yB-1gq7A:
undetectable		 1d4yB-1gq7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A 115
GLY A 298
VAL A 260
LEU A 261
LEU A 264
 None
 0.96A 1mx1C-1gq7A:
undetectable		 1mx1C-1gq7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		4 / 4 LEU A 301
VAL A 267
CYH A 266
ALA A 218
 None
 1.08A 1mz9E-1gq7A:
0.0		 1mz9E-1gq7A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		3 / 3 THR A 149
THR A 162
PRO A 151
 None
 0.81A 1qfiB-1gq7A:
undetectable		 1qfiB-1gq7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		4 / 7 LEU A 261
VAL A 260
VAL A 277
ILE A 236
 None
 0.89A 1t87B-1gq7A:
undetectable		 1t87B-1gq7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.42A 1v8bA-1gq7A:
2.9		 1v8bA-1gq7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.41A 1v8bB-1gq7A:
2.9		 1v8bB-1gq7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.41A 1v8bD-1gq7A:
3.1		 1v8bD-1gq7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		3 / 3 THR A 162
PRO A 151
THR A 149
 None
 0.76A 209dC-1gq7A:
undetectable		 209dC-1gq7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		3 / 3 ASP A 219
VAL A 225
PRO A 272
 None
 0.79A 2avvA-1gq7A:
0.0		 2avvA-1gq7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 9 ALA A 244
GLY A 288
ILE A 292
VAL A 277
ILE A 236
 None
 0.94A 2q5kA-1gq7A:
undetectable		 2q5kA-1gq7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_A_CSCA1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 11 THR A 124
LEU A 123
ARG A 184
ASP A 144
PHE A 164
 None
None
None
MN  A 350 ( 2.6A)
None
 1.48A 2vavA-1gq7A:
3.3		 2vavA-1gq7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_B_CSCB1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 THR A 124
LEU A 123
ARG A 184
ASP A 144
PHE A 164
 None
None
None
MN  A 350 ( 2.6A)
None
 1.44A 2vavB-1gq7A:
3.2		 2vavB-1gq7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_I_CSCI1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 THR A 124
LEU A 123
ARG A 184
ASP A 144
PHE A 164
 None
None
None
MN  A 350 ( 2.6A)
None
 1.43A 2vavI-1gq7A:
3.2		 2vavI-1gq7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_J_CSCJ1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 THR A 124
LEU A 123
ARG A 184
ASP A 144
PHE A 164
 None
None
None
MN  A 350 ( 2.6A)
None
 1.48A 2vavJ-1gq7A:
3.3		 2vavJ-1gq7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		4 / 7 VAL A 140
ASP A 276
HIS A 121
ILE A 168
 None
None
MN  A 350 (-3.3A)
None
 0.99A 3avpA-1gq7A:
0.0		 3avpA-1gq7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 11 VAL A 125
LEU A 128
GLY A 167
ILE A 168
SER A 147
 None
 1.22A 3bjwB-1gq7A:
undetectable		 3bjwB-1gq7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 11 VAL A 125
LEU A 128
GLY A 167
ILE A 168
SER A 147
 None
 1.23A 3bjwE-1gq7A:
undetectable		 3bjwE-1gq7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 VAL A 125
LEU A 128
GLY A 167
ILE A 168
SER A 147
 None
 1.17A 3bjwF-1gq7A:
0.0		 3bjwF-1gq7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 11 VAL A 125
LEU A 128
GLY A 167
ILE A 168
SER A 147
 None
 1.19A 3bjwH-1gq7A:
0.0		 3bjwH-1gq7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		4 / 5 HIS A 160
ASP A 148
HIS A 146
ASP A 144
 None
MN  A 350 (-2.5A)
MN  A 351 (-3.3A)
MN  A 350 ( 2.6A)
 1.26A 3c0zA-1gq7A:
11.0		 3c0zA-1gq7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.39A 3ce6D-1gq7A:
undetectable		 3ce6D-1gq7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 9 ASP A 235
ASP A 276
ILE A 117
GLY A 119
ILE A 236
 MN  A 351 ( 2.9A)
None
None
None
None
 1.20A 3ekyB-1gq7A:
undetectable		 3ekyB-1gq7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A  67
GLY A 298
GLY A  65
THR A 295
VAL A 277
 None
 1.06A 3embA-1gq7A:
undetectable		 3embA-1gq7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		6 / 9 HIS A 146
ASP A 148
ASN A 150
HIS A 160
GLY A 161
THR A 249
 MN  A 351 (-3.3A)
MN  A 350 (-2.5A)
None
None
None
None
 0.61A 3gn0A-1gq7A:
32.4		 3gn0A-1gq7A:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		6 / 9 HIS A 146
ASP A 148
ASN A 150
HIS A 160
GLY A 161
THR A 249
 MN  A 351 (-3.3A)
MN  A 350 (-2.5A)
None
None
None
None
 0.58A 3gn0B-1gq7A:
32.5		 3gn0B-1gq7A:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 6 SER A  60
LEU A 261
ILE A 292
ALA A 299
LEU A 302
 None
 1.24A 3kk6B-1gq7A:
undetectable		 3kk6B-1gq7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.40A 3n58C-1gq7A:
undetectable		 3n58C-1gq7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 10 ALA A 244
GLY A 288
ILE A 292
VAL A 277
ILE A 236
 None
 0.99A 3nu6A-1gq7A:
0.0		 3nu6A-1gq7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.43A 3ondA-1gq7A:
undetectable		 3ondA-1gq7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.42A 3ondB-1gq7A:
2.2		 3ondB-1gq7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 ILE A 117
ALA A  37
PHE A 114
LEU A 301
VAL A 277
 None
 1.12A 3s3vA-1gq7A:
undetectable		 3s3vA-1gq7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		4 / 6 VAL A 230
VAL A 225
ILE A 221
LEU A 264
 None
 0.98A 4l1wB-1gq7A:
undetectable		 4l1wB-1gq7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A 261
ILE A  63
LEU A 301
LEU A 302
GLY A  65
 None
 1.18A 4l9qB-1gq7A:
undetectable		 4l9qB-1gq7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 10 SER A 291
ILE A 297
VAL A 277
ALA A 244
ILE A 236
 None
 1.08A 4lbgA-1gq7A:
2.8		 4lbgA-1gq7A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 VAL A 280
ALA A  49
GLY A 118
ASP A 285
THR A 290
 None
 1.26A 4mm4A-1gq7A:
0.0		 4mm4A-1gq7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 ASP A 120
TYR A  39
SER A 122
THR A  99
ASN A  94
 None
 1.45A 4u15B-1gq7A:
undetectable		 4u15B-1gq7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.42A 5axdA-1gq7A:
undetectable		 5axdA-1gq7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 ASP A 285
HIS A 160
ASP A 148
HIS A 146
ASP A 144
 None
None
MN  A 350 (-2.5A)
MN  A 351 (-3.3A)
MN  A 350 ( 2.6A)
 1.20A 5ef8A-1gq7A:
4.4		 5ef8A-1gq7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 ASP A 285
HIS A 160
ASP A 148
HIS A 146
ASP A 144
 None
None
MN  A 350 (-2.5A)
MN  A 351 (-3.3A)
MN  A 350 ( 2.6A)
 1.18A 5ef8B-1gq7A:
4.1		 5ef8B-1gq7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A  67
GLY A 298
GLY A  65
VAL A 277
ILE A 297
 None
 1.04A 5ehiA-1gq7A:
undetectable		 5ehiA-1gq7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 GLY A 210
GLY A 216
ASP A 219
ARG A 222
GLY A 182
 None
 1.19A 5hikA-1gq7A:
4.2		 5hikA-1gq7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.38A 5m5kB-1gq7A:
2.9		 5m5kB-1gq7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.41A 5m66A-1gq7A:
2.7		 5m66A-1gq7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.40A 5m66C-1gq7A:
2.5		 5m66C-1gq7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		3 / 3 THR A 249
PRO A 163
ARG A 165
 None
 0.82A 5nd7B-1gq7A:
2.7		 5nd7B-1gq7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.41A 5utuF-1gq7A:
undetectable		 5utuF-1gq7A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 8 VAL A 238
ILE A 297
GLY A 298
LEU A 301
ILE A 221
 None
 0.89A 5vkqB-1gq7A:
undetectable
5vkqC-1gq7A:
undetectable		 5vkqB-1gq7A:
11.47
5vkqC-1gq7A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 9 VAL A 238
ILE A 297
GLY A 298
LEU A 301
ILE A 221
 None
 0.88A 5vkqC-1gq7A:
0.0
5vkqD-1gq7A:
0.0		 5vkqC-1gq7A:
11.47
5vkqD-1gq7A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 LEU A  88
LEU A 123
ALA A 127
GLY A 106
LEU A 107
 None
 1.00A 6b0iB-1gq7A:
undetectable		 6b0iB-1gq7A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 10 ALA A 244
GLY A 288
ILE A 292
VAL A 277
ILE A 236
 None
 0.97A 6dj2A-1gq7A:
undetectable		 6dj2A-1gq7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE
(Streptomyces
clavuligerus) 		5 / 12 HIS A 146
ASP A 237
THR A 247
GLY A 161
HIS A 160
 MN  A 351 (-3.3A)
MN  A 351 (-2.2A)
None
None
None
 1.38A 6f3nB-1gq7A:
3.1		 6f3nB-1gq7A:
21.80