SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 PHE A 147
ILE A 131
GLN A 145
VAL A  52
LEU A 117
 None
 1.16A 1kqwA-1gq8A:
0.0		 1kqwA-1gq8A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 THR A 186
PRO A 226
TYR A 263
 None
 0.85A 2dxrA-1gq8A:
0.0		 2dxrA-1gq8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 5 ASP A 100
LEU A  62
MET A  60
ARG A  99
 None
 1.45A 2gj5A-1gq8A:
undetectable		 2gj5A-1gq8A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 6 LEU A 261
SER A 231
THR A 233
VAL A 235
 None
 1.03A 3d2tB-1gq8A:
undetectable		 3d2tB-1gq8A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 ASN A 183
ASP A 136
GLN A 113
 None
CAC  A 501 (-3.2A)
CAC  A 501 ( 4.8A)
 0.82A 3eeyC-1gq8A:
undetectable		 3eeyC-1gq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 ASN A 183
ASP A 136
GLN A 113
 None
CAC  A 501 (-3.2A)
CAC  A 501 ( 4.8A)
 0.83A 3eeyD-1gq8A:
undetectable		 3eeyD-1gq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 ASN A 183
ASP A 136
GLN A 113
 None
CAC  A 501 (-3.2A)
CAC  A 501 ( 4.8A)
 0.82A 3eeyE-1gq8A:
undetectable		 3eeyE-1gq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 10 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.92A 3em3B-1gq8A:
undetectable		 3em3B-1gq8A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.84A 3em6B-1gq8A:
undetectable		 3em6B-1gq8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 8 GLY A 161
ILE A 159
VAL A 165
GLN A 145
 None
 0.76A 3fi0B-1gq8A:
undetectable		 3fi0B-1gq8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 8 ILE A 101
ALA A  98
PHE A  96
ALA A  91
 None
 0.92A 3hrdA-1gq8A:
0.0
3hrdB-1gq8A:
undetectable		 3hrdA-1gq8A:
24.41
3hrdB-1gq8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 PHE A 151
GLY A 207
SER A 204
ILE A 244
ARG A 175
 None
 1.28A 3iv6C-1gq8A:
undetectable		 3iv6C-1gq8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 ARG A 128
ASP A 130
ASP A 100
 None
 0.93A 3jb3A-1gq8A:
0.0		 3jb3A-1gq8A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 9 GLY A  44
ILE A  39
PHE A 126
PHE A 313
GLY A  65
 None
 1.40A 3ko0A-1gq8A:
undetectable
3ko0C-1gq8A:
undetectable		 3ko0A-1gq8A:
14.56
3ko0C-1gq8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 10 GLY A  65
GLY A  44
ILE A  39
PHE A 126
PHE A 313
 None
 1.46A 3ko0L-1gq8A:
undetectable
3ko0N-1gq8A:
undetectable		 3ko0L-1gq8A:
14.56
3ko0N-1gq8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 10 GLY A  44
ILE A  39
PHE A 126
PHE A 313
GLY A  65
 None
 1.42A 3ko0R-1gq8A:
undetectable
3ko0T-1gq8A:
undetectable		 3ko0R-1gq8A:
14.56
3ko0T-1gq8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 PRO A  30
SER A  33
ASN A   8
 None
 0.83A 3lslG-1gq8A:
0.0		 3lslG-1gq8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 10 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.99A 3oxwB-1gq8A:
undetectable		 3oxwB-1gq8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 7 LEU A 261
SER A 231
THR A 233
VAL A 235
 None
 1.03A 3ozkB-1gq8A:
undetectable		 3ozkB-1gq8A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 8 ALA A 164
GLY A 198
THR A 197
GLN A 188
 None
 0.92A 3rglA-1gq8A:
undetectable		 3rglA-1gq8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.85A 4dqbA-1gq8A:
undetectable		 4dqbA-1gq8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.87A 4dqfA-1gq8A:
undetectable		 4dqfA-1gq8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.92A 4jecB-1gq8A:
undetectable		 4jecB-1gq8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 11 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.93A 4njtA-1gq8A:
undetectable		 4njtA-1gq8A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 VAL A 234
SER A 300
PHE A 301
GLY A 198
GLY A 295
 None
 1.17A 4pevB-1gq8A:
0.0		 4pevB-1gq8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 PHE A 147
ILE A 131
GLN A 145
VAL A  52
LEU A 117
 None
 1.22A 4qzuA-1gq8A:
undetectable		 4qzuA-1gq8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 PHE A 147
ILE A 131
GLN A 145
VAL A  52
LEU A 117
 None
 1.18A 4qzuC-1gq8A:
undetectable		 4qzuC-1gq8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 11 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.89A 4rvjA-1gq8A:
undetectable		 4rvjA-1gq8A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 11 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.89A 4rvjC-1gq8A:
undetectable		 4rvjC-1gq8A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1gq8 PECTINESTERASE
(Daucus
carota) 		3 / 3 THR A  82
ASN A  85
SER A  86
 None
 0.51A 4tvtA-1gq8A:
0.0		 4tvtA-1gq8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 1.01A 5kqyA-1gq8A:
undetectable		 5kqyA-1gq8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 8 GLY A 248
LEU A 223
VAL A 185
ILE A 240
GLY A 272
 None
 0.94A 5vkqB-1gq8A:
undetectable
5vkqC-1gq8A:
undetectable		 5vkqB-1gq8A:
11.65
5vkqC-1gq8A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 9 GLY A 248
LEU A 223
VAL A 185
ILE A 240
GLY A 272
 None
 0.95A 5vkqC-1gq8A:
undetectable
5vkqD-1gq8A:
undetectable		 5vkqC-1gq8A:
11.65
5vkqD-1gq8A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1gq8 PECTINESTERASE
(Daucus
carota) 		4 / 6 SER A 121
ARG A  99
ARG A  36
ASP A 100
 None
 1.06A 5zw4A-1gq8A:
undetectable		 5zw4A-1gq8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.88A 6dh3B-1gq8A:
undetectable		 6dh3B-1gq8A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 1gq8 PECTINESTERASE
(Daucus
carota) 		5 / 12 LEU A 167
VAL A 235
ILE A 240
GLY A 207
ILE A 201
 None
 0.83A 6dh6B-1gq8A:
undetectable		 6dh6B-1gq8A:
9.94