SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 8 GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 0.80A 1ereE-1gs9A:
undetectable		 1ereE-1gs9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 8 GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 0.82A 1ereF-1gs9A:
undetectable		 1ereF-1gs9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 THR A  67
LEU A  71
LEU A  78
 None
 0.66A 1mz9C-1gs9A:
undetectable		 1mz9C-1gs9A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 8 PHE A  33
LEU A 148
ASP A 110
THR A  67
 None
 0.92A 1rmtD-1gs9A:
undetectable		 1rmtD-1gs9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 LEU A 159
TYR A 162
GLN A 163
 None
 0.65A 2wekA-1gs9A:
undetectable		 2wekA-1gs9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		4 / 6 ARG A 147
ARG A 114
GLY A 113
GLU A 121
 None
 1.02A 3k9fA-1gs9A:
undetectable
3k9fB-1gs9A:
undetectable
3k9fD-1gs9A:
undetectable		 3k9fA-1gs9A:
15.32
3k9fB-1gs9A:
15.32
3k9fD-1gs9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 ASP A 151
ARG A 103
ASP A 110
 None
 0.68A 4fp9D-1gs9A:
undetectable		 4fp9D-1gs9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 ASP A 151
ARG A 103
ASP A 110
 None
 0.84A 4fzvA-1gs9A:
undetectable		 4fzvA-1gs9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		5 / 12 LEU A  51
LEU A 137
SER A 139
SER A  44
ARG A 142
 None
 1.21A 4q0dC-1gs9A:
undetectable		 4q0dC-1gs9A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		5 / 12 LEU A  51
LEU A 137
SER A 139
SER A  44
ARG A 142
 None
 1.21A 4q0dD-1gs9A:
undetectable		 4q0dD-1gs9A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		5 / 12 GLU A 121
LEU A 133
LEU A 137
ARG A 114
LEU A  43
 None
 1.08A 5toaB-1gs9A:
2.5		 5toaB-1gs9A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 ASP A 151
ARG A 103
ASP A 110
 None
 0.75A 5zvgA-1gs9A:
undetectable		 5zvgA-1gs9A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1gs9 APOLIPOPROTEIN E
(Homo
sapiens) 		3 / 3 ASP A 151
ARG A 103
ASP A 110
 None
 0.74A 5zvgB-1gs9A:
undetectable		 5zvgB-1gs9A:
17.46