SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 11 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.25A 1akdA-1gsoA:
0.0		 1akdA-1gsoA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 368
ASN A  34
GLY A  10
ASP A 293
VAL A 384
 None
 1.06A 1ffyA-1gsoA:
undetectable		 1ffyA-1gsoA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 ASP A  82
GLY A  79
THR A  95
PRO A  94
 None
 0.97A 1n4fA-1gsoA:
undetectable		 1n4fA-1gsoA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 VAL A  81
LEU A 270
ALA A  99
LEU A  76
 None
 0.70A 1pthA-1gsoA:
0.0		 1pthA-1gsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 VAL A  81
LEU A 270
ALA A  99
LEU A  76
 None
 0.71A 1pthB-1gsoA:
0.0		 1pthB-1gsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ALA A 367
GLY A   9
ASP A 349
GLY A 348
ARG A 346
 None
 0.75A 1sqfA-1gsoA:
3.8		 1sqfA-1gsoA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 ILE A  48
LEU A   4
ILE A  53
ASP A  52
 None
 0.90A 1yc2E-1gsoA:
3.5		 1yc2E-1gsoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 11 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.16A 2a1nA-1gsoA:
0.0		 2a1nA-1gsoA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.24A 2cp4A-1gsoA:
0.0		 2cp4A-1gsoA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 368
GLY A 381
ALA A 338
ASN A   8
PHE A 365
 None
 1.07A 2dpmA-1gsoA:
3.2		 2dpmA-1gsoA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ILE A  91
ILE A   6
LEU A 319
 None
 0.54A 2prgA-1gsoA:
0.0		 2prgA-1gsoA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 LYS A 216
TYR A 271
ARG A 290
GLY A 292
GLU A 295
 None
 0.83A 2ys6A-1gsoA:
53.0		 2ys6A-1gsoA:
54.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 TYR A 271
ASN A 288
ARG A 290
GLY A 292
GLU A 295
 None
 0.74A 2ys6A-1gsoA:
53.0		 2ys6A-1gsoA:
54.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 ALA A  31
ILE A   6
PRO A  72
PRO A  75
 None
 1.01A 3fxrA-1gsoA:
undetectable		 3fxrA-1gsoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.33A 3lxiA-1gsoA:
0.0		 3lxiA-1gsoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 SER A  22
PHE A  29
LEU A  67
ASP A  66
 None
 1.01A 3m0wE-1gsoA:
undetectable
3m0wF-1gsoA:
undetectable
3m0wG-1gsoA:
undetectable
3m0wH-1gsoA:
undetectable		 3m0wE-1gsoA:
14.51
3m0wF-1gsoA:
14.51
3m0wG-1gsoA:
14.51
3m0wH-1gsoA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 7 ILE A 142
LEU A 135
GLU A 163
ALA A 167
ALA A 166
 None
 1.36A 3r9tB-1gsoA:
undetectable		 3r9tB-1gsoA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.33A 4c9nB-1gsoA:
0.0		 4c9nB-1gsoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.32A 4c9pA-1gsoA:
0.0		 4c9pA-1gsoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.35A 4c9pB-1gsoA:
0.0		 4c9pB-1gsoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 SER A 331
LEU A 332
GLN A 297
GLY A 229
LEU A 294
 None
 1.29A 4j7xB-1gsoA:
5.0		 4j7xB-1gsoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 LEU A 112
LYS A 109
THR A 108
 None
 0.57A 4lj0A-1gsoA:
0.0		 4lj0A-1gsoA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 ASP A  58
PRO A  32
VAL A  46
ALA A  47
GLY A  49
 None
 1.35A 4mmbA-1gsoA:
undetectable		 4mmbA-1gsoA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A 128
LEU A 132
VAL A 168
 None
 0.59A 4wq4A-1gsoA:
undetectable		 4wq4A-1gsoA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 LEU A 207
LYS A 322
LEU A 310
GLU A 309
 None
 1.33A 5weaA-1gsoA:
4.2		 5weaA-1gsoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.33A 6czmA-1gsoA:
0.7
6czmB-1gsoA:
1.0		 6czmA-1gsoA:
21.13
6czmB-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 GLY A 353
LEU A 354
VAL A 384
VAL A 350
LEU A 385
 None
 1.34A 6czmD-1gsoA:
undetectable
6czmF-1gsoA:
undetectable		 6czmD-1gsoA:
21.13
6czmF-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.34A 6czmD-1gsoA:
0.7
6czmE-1gsoA:
1.6		 6czmD-1gsoA:
21.13
6czmE-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 VAL A 384
VAL A 350
LEU A 385
GLY A 353
LEU A 354
 None
 1.32A 6czmE-1gsoA:
1.6
6czmF-1gsoA:
0.0		 6czmE-1gsoA:
21.13
6czmF-1gsoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 11 TYR A 266
PHE A  92
ARG A  85
ALA A 314
ALA A 260
 None
 1.29A 6efnA-1gsoA:
undetectable		 6efnA-1gsoA:
22.33