SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.02A 1v55C-1gtkA:
undetectable
1v55J-1gtkA:
0.0		 1v55C-1gtkA:
21.18
1v55J-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.03A 1v55P-1gtkA:
undetectable
1v55W-1gtkA:
0.0		 1v55P-1gtkA:
21.18
1v55W-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.01A 2dysC-1gtkA:
undetectable
2dysJ-1gtkA:
0.0		 2dysC-1gtkA:
21.18
2dysJ-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.04A 2dysP-1gtkA:
undetectable
2dysW-1gtkA:
0.0		 2dysP-1gtkA:
21.18
2dysW-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.00A 2eijC-1gtkA:
undetectable
2eijJ-1gtkA:
0.0		 2eijC-1gtkA:
21.18
2eijJ-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.03A 2eijP-1gtkA:
undetectable
2eijW-1gtkA:
0.0		 2eijP-1gtkA:
21.18
2eijW-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 0.95A 2eimC-1gtkA:
undetectable
2eimJ-1gtkA:
0.0		 2eimC-1gtkA:
21.18
2eimJ-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 0.98A 2einC-1gtkA:
undetectable
2einJ-1gtkA:
0.0		 2einC-1gtkA:
21.18
2einJ-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 6 LEU A 136
GLN A 133
LEU A 116
PHE A 108
 None
 1.00A 2einP-1gtkA:
undetectable
2einW-1gtkA:
0.0		 2einP-1gtkA:
21.18
2einW-1gtkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 GLY A 173
TRP A  18
ARG A 176
LEU A 177
 DPM  A 315 ( 4.4A)
None
DPM  A 315 ( 4.8A)
None
 1.20A 2j2pD-1gtkA:
0.0
2j2pF-1gtkA:
0.0		 2j2pD-1gtkA:
21.50
2j2pF-1gtkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 9 LEU A 294
ILE A 272
GLY A 298
LEU A 290
SER A 289
 None
 1.06A 3ai9X-1gtkA:
undetectable		 3ai9X-1gtkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 LEU A 294
ILE A 246
ILE A 272
GLY A 274
 None
 0.95A 3bufA-1gtkA:
undetectable		 3bufA-1gtkA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 4 LEU A  93
PRO A  90
LEU A  71
ARG A  74
 None
 1.08A 3hcoA-1gtkA:
undetectable		 3hcoA-1gtkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A 129
ARG A 131
GLY A 199
GLU A 102
 DPM  A 315 (-2.7A)
DPM  A 315 (-4.0A)
DPM  A 315 (-4.3A)
None
 1.21A 3k9fA-1gtkA:
1.2
3k9fB-1gtkA:
1.2
3k9fC-1gtkA:
undetectable		 3k9fA-1gtkA:
21.40
3k9fB-1gtkA:
21.40
3k9fC-1gtkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 3rr3B-1gtkA:
0.0		 3rr3B-1gtkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 3rr3C-1gtkA:
0.0		 3rr3C-1gtkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 3rr3D-1gtkA:
0.0		 3rr3D-1gtkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 7 ASN A 235
VAL A 228
GLU A 231
ARG A 101
 None
 1.22A 4mv7A-1gtkA:
3.1		 4mv7A-1gtkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.48A 4ojbA-1gtkA:
0.0		 4ojbA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.42A 4okbA-1gtkA:
undetectable		 4okbA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.43A 4okxA-1gtkA:
undetectable		 4okxA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.31A 4olmA-1gtkA:
undetectable		 4olmA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 10 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.07A 4ph9A-1gtkA:
0.0		 4ph9A-1gtkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 10 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 4ph9B-1gtkA:
0.0		 4ph9B-1gtkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 LEU A  38
ILE A   8
LEU A   6
ILE A  77
ILE A 203
 None
 0.85A 4y0rA-1gtkA:
undetectable		 4y0rA-1gtkA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 ARG A 131
GLY A 199
GLU A 102
SER A 129
 DPM  A 315 (-4.0A)
DPM  A 315 (-4.3A)
None
DPM  A 315 (-2.7A)
 1.18A 4z3oA-1gtkA:
undetectable
4z3oB-1gtkA:
undetectable		 4z3oA-1gtkA:
19.67
4z3oB-1gtkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A 129
GLY A 199
GLU A 102
ARG A 131
 DPM  A 315 (-2.7A)
DPM  A 315 (-4.3A)
None
DPM  A 315 (-4.0A)
 1.10A 5cdqR-1gtkA:
0.1
5cdqS-1gtkA:
undetectable
5cdqT-1gtkA:
0.7		 5cdqR-1gtkA:
21.56
5cdqS-1gtkA:
20.49
5cdqT-1gtkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A  30
ALA A  29
HIS A  31
LEU A 219
 None
 1.36A 5dzkb-1gtkA:
0.0
5dzkp-1gtkA:
undetectable		 5dzkb-1gtkA:
24.61
5dzkp-1gtkA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A  30
ALA A  29
HIS A  31
LEU A 219
 None
 1.39A 5dzkc-1gtkA:
undetectable
5dzkq-1gtkA:
undetectable		 5dzkc-1gtkA:
24.61
5dzkq-1gtkA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A  30
ALA A  29
HIS A  31
LEU A 219
 None
 1.38A 5dzkf-1gtkA:
0.0
5dzkt-1gtkA:
undetectable		 5dzkf-1gtkA:
24.61
5dzkt-1gtkA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		3 / 3 ASP A 106
ARG A 227
ARG A 260
 None
 0.89A 5eajB-1gtkA:
1.0		 5eajB-1gtkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A  39
PRO A  40
ALA A   9
ARG A 211
ILE A  77
 None
 1.27A 5hgcA-1gtkA:
undetectable		 5hgcA-1gtkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 6 GLU A 231
PRO A 194
GLY A 197
ARG A 101
 None
 1.19A 5jcnB-1gtkA:
0.3		 5jcnB-1gtkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A  98
GLY A 202
HIS A  80
VAL A  85
ALA A 225
 None
 1.22A 5n0wA-1gtkA:
2.2		 5n0wA-1gtkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 8 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.87A 5vlmA-1gtkA:
undetectable		 5vlmA-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 8 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.84A 5vlmB-1gtkA:
undetectable		 5vlmB-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 8 PRO A  90
GLN A  91
GLY A  92
LEU A  93
 None
 0.70A 5w3jB-1gtkA:
undetectable		 5w3jB-1gtkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 6 PRO A 266
ILE A 271
GLY A 268
GLU A 138
 None
 1.08A 6gqiA-1gtkA:
0.9		 6gqiA-1gtkA:
20.66