SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gtm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 10 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.14A 1pxxA-1gtmA:
0.0		 1pxxA-1gtmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 9 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.13A 1pxxB-1gtmA:
1.0		 1pxxB-1gtmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 10 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.14A 1pxxD-1gtmA:
1.0		 1pxxD-1gtmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 224
ILE A 230
ALA A 191
ASP A 234
SER A 232
 SO4  A 421 ( 4.9A)
None
None
None
None
 1.08A 1ri4A-1gtmA:
4.0		 1ri4A-1gtmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 4 SER A 195
GLU A 188
GLN A 357
ASP A 374
 None
 1.40A 2cl5A-1gtmA:
3.1		 2cl5A-1gtmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 6 SER A 195
GLU A 188
GLN A 357
ASP A 374
 None
 1.41A 2cl5B-1gtmA:
3.0		 2cl5B-1gtmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 217
ILE A 279
ILE A 215
VAL A 260
 None
 0.70A 2nniA-1gtmA:
0.7		 2nniA-1gtmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 139
PRO A 141
THR A 174
TRP A 355
 None
 1.26A 2q6oB-1gtmA:
undetectable		 2q6oB-1gtmA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 137
TYR A 159
ILE A 172
 None
 0.75A 3eteA-1gtmA:
49.2
3eteB-1gtmA:
49.3		 3eteA-1gtmA:
38.43
3eteB-1gtmA:
38.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8F_A_DM1A127_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 10 MET A 377
ALA A 380
VAL A 384
ALA A 403
VAL A 348
 None
 1.04A 3f8fA-1gtmA:
0.0
3f8fB-1gtmA:
0.0		 3f8fA-1gtmA:
15.35
3f8fB-1gtmA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 198
ALA A 216
ILE A 230
ALA A 191
PRO A 294
 None
 1.05A 3jb1A-1gtmA:
0.0		 3jb1A-1gtmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 11 GLY A 219
ALA A 296
ILE A 217
ALA A 228
ASP A 244
 None
None
None
None
SO4  A 420 (-3.9A)
 1.15A 3nmuB-1gtmA:
0.0
3nmuJ-1gtmA:
3.2		 3nmuB-1gtmA:
21.14
3nmuJ-1gtmA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  37
ILE A 107
TYR A 126
ILE A 134
TYR A 131
 None
 1.48A 3q5pA-1gtmA:
0.0		 3q5pA-1gtmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 402
ILE A 313
ILE A 338
LEU A 342
VAL A  95
 None
 1.21A 3w68C-1gtmA:
undetectable		 3w68C-1gtmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.09A 4coxA-1gtmA:
0.0		 4coxA-1gtmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.10A 4coxB-1gtmA:
1.1		 4coxB-1gtmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.11A 4coxD-1gtmA:
0.1		 4coxD-1gtmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 241
ILE A 249
GLY A 248
ILE A 279
 None
 0.59A 4eatA-1gtmA:
2.8		 4eatA-1gtmA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 194
TYR A 196
GLY A 185
GLY A 346
ASP A 234
 None
 1.18A 4mm9A-1gtmA:
0.3		 4mm9A-1gtmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.08A 4otyA-1gtmA:
1.0		 4otyA-1gtmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.09A 4otyB-1gtmA:
1.1		 4otyB-1gtmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 194
GLY A 224
ILE A 198
VAL A 239
 None
SO4  A 421 ( 4.9A)
None
None
 0.82A 4r21A-1gtmA:
0.0		 4r21A-1gtmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.08A 4rrxA-1gtmA:
0.7		 4rrxA-1gtmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.08A 4rrxB-1gtmA:
0.9		 4rrxB-1gtmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 11 GLY A  69
ILE A 359
ASN A 358
ASP A 139
PRO A  66
 None
 1.16A 4rtrA-1gtmA:
undetectable		 4rtrA-1gtmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  69
ILE A 359
ASN A 358
ASP A 139
PRO A  66
 None
 1.15A 4rtsA-1gtmA:
undetectable		 4rtsA-1gtmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 5 SER A 195
GLU A 188
GLN A 357
ASP A 374
 None
 1.41A 5fhrB-1gtmA:
3.1		 5fhrB-1gtmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 9 LEU A 122
ILE A 151
ILE A 108
PHE A  53
VAL A  52
 None
 1.47A 5igzA-1gtmA:
undetectable		 5igzA-1gtmA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.03A 5ikqA-1gtmA:
undetectable		 5ikqA-1gtmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.01A 5ikqB-1gtmA:
undetectable		 5ikqB-1gtmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.03A 5iktA-1gtmA:
0.0		 5iktA-1gtmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 10 THR A 197
ALA A 380
ALA A 194
GLY A 193
ALA A 345
 None
 1.15A 5lf3H-1gtmA:
undetectable
5lf3I-1gtmA:
undetectable		 5lf3H-1gtmA:
20.62
5lf3I-1gtmA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		5 / 10 THR A 197
ALA A 380
ALA A 194
GLY A 193
ALA A 345
 None
 1.14A 5lf3V-1gtmA:
undetectable
5lf3W-1gtmA:
undetectable		 5lf3V-1gtmA:
20.62
5lf3W-1gtmA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 8 ALA A  86
THR A  90
THR A  93
ALA A 410
 None
 0.92A 5x2tI-1gtmA:
undetectable
5x2tJ-1gtmA:
undetectable
5x2tK-1gtmA:
undetectable
5x2tL-1gtmA:
undetectable		 5x2tI-1gtmA:
16.79
5x2tJ-1gtmA:
16.90
5x2tK-1gtmA:
16.79
5x2tL-1gtmA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 309
LEU A 285
ILE A 338
ALA A 296
 None
 0.78A 6b5vA-1gtmA:
0.0
6b5vC-1gtmA:
0.0		 6b5vA-1gtmA:
11.46
6b5vC-1gtmA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 296
ILE A 309
LEU A 285
ILE A 338
 None
 0.75A 6b5vA-1gtmA:
0.0
6b5vB-1gtmA:
0.0		 6b5vA-1gtmA:
11.46
6b5vB-1gtmA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 309
LEU A 285
ILE A 338
ALA A 296
 None
 0.79A 6b5vC-1gtmA:
0.0
6b5vD-1gtmA:
undetectable		 6b5vC-1gtmA:
11.46
6b5vD-1gtmA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1gtm GLUTAMATE
DEHYDROGENASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 296
ILE A 309
LEU A 285
ILE A 338
 None
 0.78A 6b5vB-1gtmA:
undetectable
6b5vD-1gtmA:
undetectable		 6b5vB-1gtmA:
11.46
6b5vD-1gtmA:
11.46