SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gtu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A  85
GLU A  88
GLU A  92
ALA A 148
VAL A 155
 None
 1.11A 1ctrA-1gtuA:
undetectable		 1ctrA-1gtuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A   3
TYR A  27
LEU A  20
TYR A  78
ILE A  75
 None
 1.21A 1fmlB-1gtuA:
1.1		 1fmlB-1gtuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A  17
ALA A  13
ILE A  75
PRO A  60
 None
 1.24A 1oniB-1gtuA:
undetectable
1oniC-1gtuA:
undetectable		 1oniB-1gtuA:
21.80
1oniC-1gtuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 126
LEU A 165
ILE A 113
PHE A 119
PHE A 208
 None
 1.14A 1xomA-1gtuA:
undetectable		 1xomA-1gtuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 126
LEU A 165
ILE A 113
PHE A 119
PHE A 208
 None
 1.14A 1xomB-1gtuA:
undetectable		 1xomB-1gtuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 5 TYR A  32
THR A  33
ARG A  42
LEU A  46
 None
 1.03A 3qelC-1gtuA:
undetectable		 3qelC-1gtuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A 126
ILE A 113
PHE A 119
PHE A 208
 None
 0.94A 3tvxB-1gtuA:
undetectable		 3tvxB-1gtuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		4 / 6 ASP A 161
HIS A  14
ILE A  16
TYR A   6
 None
 1.24A 5ih0A-1gtuA:
0.0		 5ih0A-1gtuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 156
ILE A 184
HIS A  14
PHE A 187
ASP A 161
 None
 1.38A 6fbpA-1gtuA:
undetectable
6fbpB-1gtuA:
undetectable		 6fbpA-1gtuA:
15.81
6fbpB-1gtuA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens) 		3 / 3 ASP A 161
LEU A 165
ARG A 205
 None
 0.81A 7dfrA-1gtuA:
undetectable		 7dfrA-1gtuA:
20.98