SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1guq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ARG A  13
ALA A 227
ALA A 331
GLU A 329
 None
 1.13A 1e7bA-1guqA:
0.0		 1e7bA-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ARG A  13
ALA A 227
ALA A 332
GLU A 329
 None
 1.13A 1e7bA-1guqA:
0.0		 1e7bA-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ARG A  13
ALA A 227
ALA A 331
GLU A 329
 None
 1.16A 1e7bB-1guqA:
undetectable		 1e7bB-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 4 ARG A  13
ALA A 227
ALA A 332
GLU A 329
 None
 1.07A 1e7bB-1guqA:
undetectable		 1e7bB-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A  13
ALA A 227
ALA A 331
GLU A 329
 None
 1.23A 1e7cA-1guqA:
undetectable		 1e7cA-1guqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 TYR A 276
TRP A 134
ILE A 130
LEU A 262
 None
 1.14A 1j96A-1guqA:
undetectable		 1j96A-1guqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 ILE A 169
ILE A 109
THR A 105
 None
 0.59A 1rg7A-1guqA:
undetectable		 1rg7A-1guqA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A 119
ALA A 256
LEU A 122
SER A 123
 None
 1.13A 1tt6B-1guqA:
0.0		 1tt6B-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 119
LEU A 122
SER A 123
THR A 128
 None
 1.27A 1tyrA-1guqA:
undetectable		 1tyrA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 GLU A 215
THR A 216
LEU A 235
 None
 0.61A 1v8bC-1guqA:
undetectable		 1v8bC-1guqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 8 MET A 158
ALA A 157
THR A  39
THR A 308
 None
 0.98A 2kotB-1guqA:
undetectable		 2kotB-1guqA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A 134
VAL A 148
TRP A 280
 None
 1.25A 2xdcC-1guqA:
undetectable
2xdcD-1guqA:
undetectable		 2xdcC-1guqA:
4.36
2xdcD-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A 134
VAL A 148
TRP A 280
 None
 1.21A 2xdcE-1guqA:
undetectable
2xdcF-1guqA:
undetectable		 2xdcE-1guqA:
4.36
2xdcF-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A 134
VAL A 148
TRP A 280
 None
 1.23A 2y5mE-1guqA:
undetectable
2y5mF-1guqA:
undetectable		 2y5mE-1guqA:
4.36
2y5mF-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A 134
VAL A 148
TRP A 280
 None
 1.23A 2y6nC-1guqA:
undetectable
2y6nD-1guqA:
undetectable		 2y6nC-1guqA:
4.36
2y6nD-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A 134
VAL A 148
TRP A 280
 None
 1.25A 2y6nE-1guqA:
undetectable
2y6nF-1guqA:
undetectable		 2y6nE-1guqA:
4.36
2y6nF-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 6 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
 None
 1.47A 3cfqA-1guqA:
undetectable		 3cfqA-1guqA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 7 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
 None
 1.43A 3d2tA-1guqA:
undetectable		 3d2tA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ARG A 204
ARG A 336
VAL A 213
ALA A 328
TYR A 225
 None
 1.29A 3qxvE-1guqA:
undetectable		 3qxvE-1guqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 PHE A 270
GLN A  37
PHE A 231
 None
 0.74A 3rv5A-1guqA:
0.0		 3rv5A-1guqA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A 201
THR A 212
ARG A 336
LEU A 335
 None
 1.30A 3wipG-1guqA:
0.2
3wipH-1guqA:
0.2		 3wipG-1guqA:
20.96
3wipH-1guqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A 134
VAL A 148
TRP A 280
 None
 1.45A 3zq8A-1guqA:
undetectable
3zq8B-1guqA:
undetectable		 3zq8A-1guqA:
4.36
3zq8B-1guqA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 6 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
 None
 1.43A 4i89A-1guqA:
undetectable		 4i89A-1guqA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 119
ALA A 256
LEU A 122
SER A 123
 None
 1.04A 4ikjA-1guqA:
undetectable
4ikjB-1guqA:
undetectable		 4ikjA-1guqA:
16.81
4ikjB-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A  82
ASP A  85
ILE A 169
 None
 0.58A 4xi3D-1guqA:
undetectable		 4xi3D-1guqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 TYR A 276
TRP A 134
ILE A 130
LEU A 262
 None
 1.17A 4xo7B-1guqA:
undetectable		 4xo7B-1guqA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLU A 205
GLU A 329
ALA A 328
TYR A 225
 None
 1.14A 4zz8A-1guqA:
0.0		 4zz8A-1guqA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 6 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
 None
 1.40A 5bojA-1guqA:
0.0		 5bojA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 248
ASP A 249
ALA A 250
 None
 0.06A 5g5gB-1guqA:
0.0		 5g5gB-1guqA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 6 LEU A 119
ALA A 256
LEU A 122
SER A 123
THR A 128
 None
 1.44A 5l4iA-1guqA:
undetectable		 5l4iA-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 119
LEU A 122
SER A 123
THR A 128
 None
 1.28A 5l4iB-1guqA:
undetectable		 5l4iB-1guqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLY A 159
TRP A 170
GLN A 149
TYR A 276
 UPG  A 352 (-3.8A)
UPG  A 352 ( 4.9A)
None
None
 1.27A 5vlmG-1guqA:
undetectable		 5vlmG-1guqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 1guq GALACTOSE-1-PHOSPHAT
E
URIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 335
VAL A 214
VAL A 202
LEU A 262
PHE A 299
 None
 1.37A 6a7pB-1guqA:
undetectable		 6a7pB-1guqA:
20.44