SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 461
ALA A 490
GLY A 449
TYR A 453
PHE A 404
 None
 1.43A 1l5rA-1guxA:
undetectable		 1l5rA-1guxA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1gux RETINOBLASTOMA
PROTEIN
RETINOBLASTOMA
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE A 526
PHE B 650
PHE A 570
SER A 567
 None
 1.33A 3hggA-1guxA:
undetectable		 3hggA-1guxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 542
ILE A 388
ALA A 490
LEU A 491
 None
 0.85A 3kk6B-1guxA:
2.6		 3kk6B-1guxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 572
ASP A 571
LYS A 574
SER A 567
 None
 1.37A 3lslA-1guxA:
undetectable
3lslD-1guxA:
undetectable		 3lslA-1guxA:
22.61
3lslD-1guxA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1gux RETINOBLASTOMA
PROTEIN
RETINOBLASTOMA
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 MET B 695
LEU B 688
ARG B 661
SER A 567
 None
 0.89A 4kmmB-1guxB:
undetectable		 4kmmB-1guxB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 473
LYS A 472
ASN A 410
PRO A 411
 None
 1.27A 4yv5B-1guxA:
0.7		 4yv5B-1guxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 473
LYS A 472
ASN A 410
PRO A 411
 None
 1.27A 4yv5A-1guxA:
0.0		 4yv5A-1guxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 724
ALA B 727
ARG B 668
ALA B 734
PHE B 721
 None
 1.44A 4zo1X-1guxB:
3.0		 4zo1X-1guxB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 562
LEU A 550
ILE A 382
PHE A 535
PHE A 514
 None
 1.02A 5fsaA-1guxA:
undetectable		 5fsaA-1guxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1gux RETINOBLASTOMA
PROTEIN
RETINOBLASTOMA
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASP B 701
THR B 738
GLN B 702
GLU A 559
 None
 1.16A 5k9dA-1guxB:
undetectable		 5k9dA-1guxB:
17.12