SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1guz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		3 / 3 ALA A 250
VAL A 139
TRP A 129
 None
 0.96A 1c4dA-1guzA:
undetectable
1c4dB-1guzA:
undetectable		 1c4dA-1guzA:
4.00
1c4dB-1guzA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		3 / 3 ALA A 250
VAL A 139
TRP A 129
 None
 0.91A 1c4dC-1guzA:
undetectable
1c4dD-1guzA:
undetectable		 1c4dC-1guzA:
4.00
1c4dD-1guzA:
4.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 9 GLY A   7
ASP A  32
ALA A  77
ILE A  97
GLU A 100
 NAD  A1306 ( 4.0A)
NAD  A1306 (-3.0A)
NAD  A1306 ( 3.8A)
NAD  A1306 (-3.8A)
NAD  A1306 (-3.8A)
 0.73A 1cetA-1guzA:
42.4		 1cetA-1guzA:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 9 GLY A   7
ASP A  32
TYR A  64
ALA A  77
ILE A  97
 NAD  A1306 ( 4.0A)
NAD  A1306 (-3.0A)
None
NAD  A1306 ( 3.8A)
NAD  A1306 (-3.8A)
 0.75A 1cetA-1guzA:
42.4		 1cetA-1guzA:
40.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		3 / 3 LYS A 136
ILE A 113
THR A 102
 None
 0.61A 1rx3A-1guzA:
undetectable		 1rx3A-1guzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		4 / 9 ALA A 295
VAL A 298
CYH A 302
LYS A 303
 None
 0.88A 2vufB-1guzA:
0.0		 2vufB-1guzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		4 / 7 VAL A 116
ASN A  94
GLY A  96
VAL A 101
 None
NAD  A1306 ( 4.5A)
None
None
 0.94A 2y05A-1guzA:
5.5
2y05B-1guzA:
5.5		 2y05A-1guzA:
24.04
2y05B-1guzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 12 VAL A   5
VAL A  58
VAL A 117
ILE A 115
THR A  76
 None
None
NAD  A1306 (-4.2A)
None
None
 1.09A 3czhA-1guzA:
0.0		 3czhA-1guzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 12 PHE A 225
GLY A  12
GLY A   9
ALA A  16
THR A  15
 None
None
NAD  A1306 (-3.2A)
None
None
 1.10A 3dh0B-1guzA:
5.8		 3dh0B-1guzA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 12 VAL A   5
VAL A  58
VAL A 117
ILE A 115
THR A  76
 None
None
NAD  A1306 (-4.2A)
None
None
 1.10A 3dl9A-1guzA:
0.0		 3dl9A-1guzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 11 GLN A  39
PRO A  38
ASP A  32
VAL A 101
ILE A  97
 None
None
NAD  A1306 (-3.0A)
None
NAD  A1306 (-3.8A)
 1.13A 3n23A-1guzA:
3.6		 3n23A-1guzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 9 GLY A  78
ALA A  77
GLY A  12
VAL A  11
ILE A  75
 NAD  A1306 (-4.2A)
NAD  A1306 ( 3.8A)
None
NAD  A1306 (-3.5A)
None
 0.98A 3oxvC-1guzA:
undetectable		 3oxvC-1guzA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		4 / 6 ILE A 192
VAL A 181
LEU A 171
CYH A 169
 None
 0.94A 4asdA-1guzA:
undetectable		 4asdA-1guzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		3 / 3 LYS A 136
ILE A 113
THR A 102
 None
 0.63A 4gh8A-1guzA:
undetectable		 4gh8A-1guzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 10 ALA A 128
ILE A  75
VAL A 101
GLY A  96
VAL A 116
 None
 1.03A 4j5jB-1guzA:
undetectable		 4j5jB-1guzA:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 9 ASP A  32
VAL A  33
TYR A  64
ALA A  77
ILE A  97
 NAD  A1306 (-3.0A)
NAD  A1306 (-4.4A)
None
NAD  A1306 ( 3.8A)
NAD  A1306 (-3.8A)
 0.64A 4oknB-1guzA:
41.4		 4oknB-1guzA:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 12 LEU A  28
ILE A  72
ILE A 239
VAL A   5
ILE A   3
 None
 0.79A 4q1xB-1guzA:
0.0		 4q1xB-1guzA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 12 LEU A  28
ILE A  72
ILE A 239
VAL A   5
ILE A   3
 None
 0.89A 4q1yB-1guzA:
undetectable		 4q1yB-1guzA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 12 GLY A 141
ILE A  74
THR A 102
ILE A   3
THR A  15
 None
 1.03A 4q5mA-1guzA:
undetectable		 4q5mA-1guzA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		4 / 7 LEU A 171
PRO A 267
LEU A 291
TYR A 257
 None
 1.07A 4z4fA-1guzA:
undetectable		 4z4fA-1guzA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		4 / 7 GLN A 256
GLY A 252
ASP A 122
ASP A 299
 None
 1.09A 5vlmE-1guzA:
0.0		 5vlmE-1guzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1guz MALATE DEHYDROGENASE
(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis) 		5 / 9 LEU A  31
THR A  67
ILE A 105
VAL A 101
ILE A   6
 None
 1.23A 6ef6A-1guzA:
0.0		 6ef6A-1guzA:
20.91