SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		3 / 3 ALA A 250
VAL A 139
TRP A 129
 None
 0.99A 1c4dA-1gv0A:
undetectable
1c4dB-1gv0A:
undetectable		 1c4dA-1gv0A:
4.00
1c4dB-1gv0A:
4.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 9 GLY A   7
ASP A  32
ALA A  77
ILE A  97
GLU A 100
 NAD  A1306 ( 4.1A)
NAD  A1306 (-3.1A)
NAD  A1306 (-3.6A)
NAD  A1306 (-4.1A)
NAD  A1306 (-4.2A)
 0.72A 1cetA-1gv0A:
41.5		 1cetA-1gv0A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		4 / 8 ILE A 113
MET A 235
GLY A 274
LEU A 270
 None
 1.00A 1dzmA-1gv0A:
0.1		 1dzmA-1gv0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 11 LEU A  30
THR A  59
ILE A  75
THR A  76
VAL A  74
 None
 1.08A 1pkvA-1gv0A:
undetectable
1pkvB-1gv0A:
undetectable		 1pkvA-1gv0A:
16.99
1pkvB-1gv0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 11 VAL A  74
LEU A  30
THR A  59
ILE A  75
THR A  76
 None
 1.12A 1pkvA-1gv0A:
undetectable
1pkvB-1gv0A:
0.0		 1pkvA-1gv0A:
16.99
1pkvB-1gv0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		3 / 3 LYS A 136
ILE A 113
THR A 102
 None
 0.81A 1rx3A-1gv0A:
undetectable		 1rx3A-1gv0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 GLY A 144
ALA A 250
ASP A 147
ALA A 143
ARG A 150
 None
None
None
NAD  A1306 ( 4.7A)
None
 1.31A 2avdB-1gv0A:
4.7		 2avdB-1gv0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		4 / 8 THR A   4
VAL A  29
ALA A  65
ARG A 104
 None
 1.17A 2ij7C-1gv0A:
0.0		 2ij7C-1gv0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		4 / 9 ALA A 295
VAL A 298
CYH A 302
LYS A 303
 None
 0.76A 2vufB-1gv0A:
0.0		 2vufB-1gv0A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 PHE A 225
GLY A  12
GLY A   9
VAL A  74
VAL A 232
 None
None
NAD  A1306 (-3.2A)
None
None
 1.03A 2zulA-1gv0A:
6.9		 2zulA-1gv0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 ASN A  94
VAL A  98
GLY A   7
ILE A  37
GLN A  39
 NAD  A1306 (-4.1A)
None
NAD  A1306 ( 4.1A)
None
None
 1.01A 3bwmA-1gv0A:
6.9		 3bwmA-1gv0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 PHE A 225
GLY A  12
GLY A   9
ALA A  16
THR A  15
 None
None
NAD  A1306 (-3.2A)
None
None
 1.10A 3dh0B-1gv0A:
7.6		 3dh0B-1gv0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 PHE A 225
GLY A  12
GLY A   9
VAL A  74
VAL A 232
 None
None
NAD  A1306 (-3.2A)
None
None
 1.03A 3dmfA-1gv0A:
7.2		 3dmfA-1gv0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 PHE A 225
GLY A  12
GLY A   9
VAL A  74
VAL A 232
 None
None
NAD  A1306 (-3.2A)
None
None
 1.02A 3dmhA-1gv0A:
7.2		 3dmhA-1gv0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 11 GLN A  39
PRO A  38
ASP A  32
VAL A 101
ILE A  97
 None
None
NAD  A1306 (-3.1A)
None
NAD  A1306 (-4.1A)
 1.15A 3n23A-1gv0A:
undetectable		 3n23A-1gv0A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		3 / 3 GLY A 172
ILE A 297
VAL A 298
 None
 0.48A 3nv6A-1gv0A:
undetectable		 3nv6A-1gv0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		3 / 3 LYS A 136
ILE A 113
THR A 102
 None
 0.82A 4gh8A-1gv0A:
undetectable		 4gh8A-1gv0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 10 ALA A 128
ILE A  75
VAL A 101
GLY A  96
VAL A 116
 None
 0.99A 4j5jB-1gv0A:
undetectable		 4j5jB-1gv0A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		4 / 8 VAL A  73
GLY A 103
VAL A 116
ILE A 114
 None
 0.69A 4ll3A-1gv0A:
undetectable		 4ll3A-1gv0A:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 9 ASP A  32
VAL A  33
TYR A  64
ALA A  77
ILE A  97
 NAD  A1306 (-3.1A)
NAD  A1306 (-4.2A)
None
NAD  A1306 (-3.6A)
NAD  A1306 (-4.1A)
 0.52A 4oknB-1gv0A:
39.9		 4oknB-1gv0A:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A  28
ILE A  72
ILE A 239
VAL A   5
ILE A   3
 None
 0.80A 4q1xB-1gv0A:
0.0		 4q1xB-1gv0A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A  28
ILE A  72
ILE A 239
VAL A   5
ILE A   3
 None
 0.93A 4q1yB-1gv0A:
undetectable		 4q1yB-1gv0A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 ASN A  94
VAL A  98
GLY A   7
ILE A  37
GLN A  39
 NAD  A1306 (-4.1A)
None
NAD  A1306 ( 4.1A)
None
None
 1.08A 4xucA-1gv0A:
6.9		 4xucA-1gv0A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		4 / 7 LEU A 171
PRO A 267
LEU A 291
TYR A 257
 None
 1.06A 4z4fA-1gv0A:
undetectable		 4z4fA-1gv0A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 9 LEU A 305
ASN A  94
ALA A  95
VAL A  98
ARG A  99
 None
NAD  A1306 (-4.1A)
None
None
None
 1.02A 4zbrA-1gv0A:
undetectable		 4zbrA-1gv0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 9 LEU A 305
ASN A  94
ALA A  95
VAL A  98
ARG A  99
 None
NAD  A1306 (-4.1A)
None
None
None
 1.00A 5dbyA-1gv0A:
undetectable		 5dbyA-1gv0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 12 ASN A  94
VAL A  98
GLY A   7
ILE A  37
GLN A  39
 NAD  A1306 (-4.1A)
None
NAD  A1306 ( 4.1A)
None
None
 1.01A 5lsaA-1gv0A:
7.2		 5lsaA-1gv0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		3 / 3 LEU A 121
ASP A 299
ILE A 259
 NAD  A1306 ( 4.1A)
None
None
 0.52A 6dh0B-1gv0A:
undetectable		 6dh0B-1gv0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1gv0 MALATE DEHYDROGENASE
(Chlorobaculum
tepidum) 		5 / 9 LEU A  31
THR A  67
ILE A 105
VAL A 101
ILE A   6
 None
 1.10A 6ef6A-1gv0A:
0.0		 6ef6A-1gv0A:
20.70