SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		4 / 6 ALA A 263
ILE A 241
VAL A 244
GLU A 245
 None
 0.93A 2cizA-1gveA:
undetectable		 2cizA-1gveA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		4 / 7 LEU A 291
PRO A   6
VAL A 298
MET A 267
 None
 1.26A 2hrcA-1gveA:
0.1		 2hrcA-1gveA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		4 / 6 LEU A 303
PRO A 305
ARG A 265
HIS A 269
 None
 1.46A 3ltwA-1gveA:
0.0		 3ltwA-1gveA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 10 ASP A  20
SER A  27
PHE A  31
ILE A  39
LEU A  54
 None
 1.48A 3m0wC-1gveA:
undetectable
3m0wD-1gveA:
undetectable
3m0wE-1gveA:
undetectable
3m0wF-1gveA:
undetectable		 3m0wC-1gveA:
16.94
3m0wD-1gveA:
16.94
3m0wE-1gveA:
16.94
3m0wF-1gveA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 10 LEU A  54
SER A  27
PHE A  31
ILE A  39
ASP A  20
 None
 1.44A 3m0wE-1gveA:
undetectable
3m0wF-1gveA:
undetectable
3m0wG-1gveA:
undetectable
3m0wH-1gveA:
undetectable		 3m0wE-1gveA:
16.94
3m0wF-1gveA:
16.94
3m0wG-1gveA:
16.94
3m0wH-1gveA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 10 LEU A  54
SER A  27
PHE A  31
ILE A  39
ASP A  20
 None
 1.42A 3m0wA-1gveA:
undetectable
3m0wB-1gveA:
undetectable
3m0wI-1gveA:
undetectable
3m0wJ-1gveA:
undetectable		 3m0wA-1gveA:
16.94
3m0wB-1gveA:
16.94
3m0wI-1gveA:
16.94
3m0wJ-1gveA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		4 / 6 VAL A 163
TYR A 107
TYR A 191
GLU A  38
 None
 0.79A 3q5sA-1gveA:
0.0		 3q5sA-1gveA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 12 VAL A 281
ALA A 280
TYR A 107
TYR A 164
PHE A 190
 None
 1.17A 3qxyA-1gveA:
undetectable		 3qxyA-1gveA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 11 VAL A 281
ALA A 280
TYR A 107
TYR A 164
PHE A 190
 None
 1.14A 3qxyB-1gveA:
0.0
3qxyQ-1gveA:
undetectable		 3qxyB-1gveA:
21.67
3qxyQ-1gveA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 11 VAL A 281
ALA A 280
TYR A 107
TYR A 164
PHE A 190
 None
 1.15A 3rc0A-1gveA:
undetectable		 3rc0A-1gveA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 12 VAL A 281
ALA A 280
TYR A 107
TYR A 164
PHE A 190
 None
 1.15A 3rc0B-1gveA:
undetectable		 3rc0B-1gveA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		4 / 8 VAL A  44
TYR A  45
HIS A 109
LEU A 227
 None
CIT  A1331 ( 4.6A)
CIT  A1331 (-4.0A)
None
 1.03A 4jtrA-1gveA:
23.4		 4jtrA-1gveA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 12 PHE A 311
LEU A 317
GLY A 199
MET A 259
THR A 202
 None
None
NAP  A1328 (-3.2A)
None
NAP  A1328 ( 4.0A)
 1.14A 4mubA-1gveA:
undetectable		 4mubA-1gveA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 12 GLY A  11
LEU A 291
MET A 285
ARG A 218
THR A   8
 NAP  A1328 (-3.1A)
None
None
NAP  A1328 (-3.0A)
None
 1.47A 4okxA-1gveA:
0.2		 4okxA-1gveA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 12 GLY A  11
LEU A 291
MET A 285
ARG A 218
THR A   8
 NAP  A1328 (-3.1A)
None
None
NAP  A1328 (-3.0A)
None
 1.41A 4olmA-1gveA:
undetectable		 4olmA-1gveA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		4 / 7 PHE A 190
LEU A 183
VAL A 175
PHE A 326
 None
GOL  A1330 ( 4.6A)
None
None
 0.93A 4wnvD-1gveA:
0.0		 4wnvD-1gveA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 12 PHE A 311
LEU A 317
GLY A 199
MET A 259
THR A 202
 None
None
NAP  A1328 (-3.2A)
None
NAP  A1328 ( 4.0A)
 1.16A 5byjA-1gveA:
undetectable		 5byjA-1gveA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Rattus
norvegicus) 		5 / 9 LEU A  82
THR A 120
LEU A 121
ILE A 149
LEU A 152
 None
 1.23A 5g48B-1gveA:
0.0		 5g48B-1gveA:
22.03