SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 6 ARG A 198
GLU A 199
GLN A 158
PRO A 157
 None
 1.49A 2qqtA-1gvfA:
0.0		 2qqtA-1gvfA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 11 ALA A 175
ALA A 173
GLY A 209
HIS A 208
GLY A 139
 None
None
PGH  A 287 ( 3.1A)
ZN  A 288 ( 3.1A)
None
 1.13A 2x1lC-1gvfA:
undetectable		 2x1lC-1gvfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		3 / 3 GLU A  29
HIS A  26
HIS A  56
 None
 0.78A 3co4A-1gvfA:
4.4		 3co4A-1gvfA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 4 LEU A 135
ASP A 202
VAL A 169
THR A 167
 None
 1.12A 3cyxB-1gvfA:
undetectable		 3cyxB-1gvfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 5 PRO A 157
THR A 227
VAL A 226
GLY A 225
 None
 0.78A 3elzA-1gvfA:
0.0		 3elzA-1gvfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 6 ARG A 198
GLU A 199
GLN A 158
PRO A 157
 None
 1.46A 3gclA-1gvfA:
0.0		 3gclA-1gvfA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 7 CYH A  38
PHE A  23
SER A 280
TYR A  18
 None
 1.49A 3hggA-1gvfA:
undetectable		 3hggA-1gvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		3 / 3 GLU A 196
ASP A 190
ASP A 156
 EDO  A1291 (-3.3A)
EDO  A1291 (-2.6A)
None
 0.57A 3jb2A-1gvfA:
0.0		 3jb2A-1gvfA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 8 GLY A 139
GLY A 209
ILE A 189
LEU A 207
VAL A 213
 None
PGH  A 287 ( 3.1A)
None
None
None
 1.35A 3v1nA-1gvfA:
undetectable		 3v1nA-1gvfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 8 VAL A  45
TYR A  18
CYH A 278
ILE A 275
 EDO  A1290 (-4.5A)
None
None
None
 1.10A 4bqtC-1gvfA:
undetectable
4bqtD-1gvfA:
0.0		 4bqtC-1gvfA:
23.93
4bqtD-1gvfA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 12 ASP A 215
PRO A  21
ILE A 222
VAL A 277
ILE A 275
 None
 1.30A 4eb6B-1gvfA:
undetectable
4eb6C-1gvfA:
undetectable		 4eb6B-1gvfA:
21.93
4eb6C-1gvfA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 11 ILE A 176
GLN A 192
PHE A 191
LEU A 194
ALA A 195
 None
 1.16A 4nqaA-1gvfA:
undetectable		 4nqaA-1gvfA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 6 SER A  86
LEU A  87
ASP A  88
LEU A 116
 None
 0.84A 4wozA-1gvfA:
9.0
4wozB-1gvfA:
12.0		 4wozA-1gvfA:
24.19
4wozB-1gvfA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 12 VAL A 229
LEU A 154
LEU A 138
ALA A 175
ALA A 179
 None
 1.26A 4x1kA-1gvfA:
undetectable
4x1kB-1gvfA:
undetectable		 4x1kA-1gvfA:
23.06
4x1kB-1gvfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 11 ILE A 176
GLN A 192
PHE A 191
LEU A 194
ALA A 195
 None
 1.17A 5ji0A-1gvfA:
undetectable		 5ji0A-1gvfA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		4 / 6 SER A 106
GLY A 136
THR A 155
ILE A 197
 None
 0.86A 6f8cA-1gvfA:
0.0		 6f8cA-1gvfA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 12 THR A  50
ASP A  82
SER A 106
VAL A 231
ASN A 230
 None
PGH  A 287 (-2.6A)
None
PGH  A 287 (-3.9A)
PGH  A 287 (-4.3A)
 1.39A 6h7lA-1gvfA:
undetectable		 6h7lA-1gvfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY
(Escherichia
coli) 		5 / 12 THR A  50
ASP A  82
SER A 106
VAL A 231
ASN A 230
 None
PGH  A 287 (-2.6A)
None
PGH  A 287 (-3.9A)
PGH  A 287 (-4.3A)
 1.39A 6h7lB-1gvfA:
undetectable		 6h7lB-1gvfA:
16.60