SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 8 PHE A  28
TYR A  29
PHE A  43
VAL A  98
 None
None
HEM  A1398 (-3.9A)
HEM  A1398 (-4.5A)
 0.87A 1fslA-1gvhA:
12.8		 1fslA-1gvhA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 4 HIS A 286
VAL A 290
THR A 280
LEU A 275
 None
 1.30A 1oq5A-1gvhA:
0.0		 1oq5A-1gvhA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 11 PHE A  43
ILE A  97
ILE A  61
LEU A  57
PHE A  28
 HEM  A1398 (-3.9A)
None
HEM  A1398 (-4.3A)
HEM  A1398 (-3.9A)
None
 1.05A 1z11B-1gvhA:
undetectable		 1z11B-1gvhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 12 ASN A  59
ALA A  63
LEU A 127
LEU A 102
THR A  25
 None
None
HEM  A1398 (-4.1A)
None
None
 1.48A 2aa6B-1gvhA:
undetectable		 2aa6B-1gvhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 4 LEU A 208
ARG A 153
LEU A 245
ALA A 181
 None
 1.18A 3b9mA-1gvhA:
2.1		 3b9mA-1gvhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 12 ASN A 142
GLY A 148
LEU A 189
THR A  86
ILE A 138
 None
 1.00A 3mneA-1gvhA:
undetectable		 3mneA-1gvhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 12 ASN A 142
GLY A 148
LEU A 189
THR A  86
ILE A 138
 None
 1.10A 3mnoA-1gvhA:
undetectable		 3mnoA-1gvhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 12 ASN A 142
GLY A 148
LEU A 189
THR A  86
ILE A 138
 None
 1.08A 3mnpA-1gvhA:
undetectable		 3mnpA-1gvhA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 12 PHE A  28
TYR A  29
LEU A 102
ALA A 123
TYR A 124
 None
None
None
None
HEM  A1398 ( 4.9A)
 0.62A 3ozuA-1gvhA:
35.7		 3ozuA-1gvhA:
45.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 10 LEU A 189
LEU A 172
ILE A 219
ALA A 220
VAL A 239
 None
 1.45A 3r9cA-1gvhA:
0.0		 3r9cA-1gvhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 12 LEU A 281
LEU A 278
LEU A 275
GLN A 271
THR A 263
 None
None
None
NA  A1400 (-4.2A)
None
 1.35A 3zqtA-1gvhA:
undetectable		 3zqtA-1gvhA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		7 / 12 THR A  25
PHE A  28
TYR A  29
PHE A  43
VAL A  98
LEU A 102
TYR A 124
 None
None
None
HEM  A1398 (-3.9A)
HEM  A1398 (-4.5A)
None
HEM  A1398 ( 4.9A)
 0.60A 4g1bA-1gvhA:
44.1		 4g1bA-1gvhA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 11 THR A  25
PHE A  28
TYR A  29
LEU A 102
TYR A 124
 None
None
None
None
HEM  A1398 ( 4.9A)
 0.45A 4g1bB-1gvhA:
44.1		 4g1bB-1gvhA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 9 THR A  25
PHE A  28
TYR A  29
VAL A  98
LEU A 102
 None
None
None
HEM  A1398 (-4.5A)
None
 0.44A 4g1bC-1gvhA:
43.3		 4g1bC-1gvhA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		6 / 12 THR A  25
PHE A  28
TYR A  29
PHE A  43
LEU A 102
TYR A 124
 None
None
None
HEM  A1398 (-3.9A)
None
HEM  A1398 ( 4.9A)
 0.64A 4g1bD-1gvhA:
44.0		 4g1bD-1gvhA:
36.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 ARG A 163
ASP A 306
ARG A 218
 None
 0.82A 4mx0A-1gvhA:
undetectable		 4mx0A-1gvhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 GLU A 108
THR A  34
HIS A  35
 None
 0.76A 4q15A-1gvhA:
undetectable		 4q15A-1gvhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 GLU A 108
THR A  34
HIS A  35
 None
 0.77A 4q15B-1gvhA:
undetectable		 4q15B-1gvhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 SER A 169
ALA A 159
VAL A 158
 None
 0.61A 4x20C-1gvhA:
4.9		 4x20C-1gvhA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 GLU A 108
THR A  34
HIS A  35
 None
 0.79A 4ydqB-1gvhA:
0.7		 4ydqB-1gvhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		5 / 9 LEU A 311
GLY A 312
LEU A 315
LEU A 281
ALA A 282
 None
 0.96A 5dqfA-1gvhA:
2.4		 5dqfA-1gvhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 VAL A  78
GLU A 141
GLU A 137
 None
 0.90A 5jsdB-1gvhA:
0.0
5jsdC-1gvhA:
0.0		 5jsdB-1gvhA:
19.83
5jsdC-1gvhA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 8 TYR A 217
GLN A 187
VAL A 180
GLY A 147
 None
 0.82A 5nzyA-1gvhA:
undetectable		 5nzyA-1gvhA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 5 ASP A  30
PRO A  22
GLU A  55
THR A  25
 None
 1.10A 5uxcA-1gvhA:
undetectable		 5uxcA-1gvhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 8 GLY A 270
CYH A 362
GLY A 363
GLU A 388
 None
None
None
FAD  A1397 (-3.6A)
 0.69A 5vw5A-1gvhA:
19.8		 5vw5A-1gvhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 6 GLY A 121
TYR A 124
LEU A   2
VAL A  10
 None
HEM  A1398 ( 4.9A)
None
None
 0.63A 5x80A-1gvhA:
1.0
5x80B-1gvhA:
0.8		 5x80A-1gvhA:
20.06
5x80B-1gvhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		3 / 3 ASN A 238
VAL A 221
HIS A 234
 None
FAD  A1397 (-3.5A)
None
 0.47A 6a5yD-1gvhA:
0.4		 6a5yD-1gvhA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1gvh FLAVOHEMOPROTEIN
(Escherichia
coli) 		4 / 7 LEU A 345
LEU A 275
GLY A 270
LEU A 361
 None
 0.81A 6eu9D-1gvhA:
0.6		 6eu9D-1gvhA:
12.60