SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 8 HIS A  57
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.47A 1aq7A-1gvlA:
27.7		 1aq7A-1gvlA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 9 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.70A 1bcuH-1gvlA:
10.2		 1bcuH-1gvlA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		6 / 12 HIS A  57
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.59A 1etrH-1gvlA:
24.8		 1etrH-1gvlA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 GLY A  44
LEU A  33
LEU A  64
VAL A  85
LEU A 108
 None
 0.88A 1gseB-1gvlA:
undetectable		 1gseB-1gvlA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		4 / 6 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.55A 1tnlA-1gvlA:
28.3		 1tnlA-1gvlA:
44.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 GLY A  44
ALA A  31
ILE A 118
ILE A  47
VAL A  66
 None
 0.84A 2b7zB-1gvlA:
undetectable		 2b7zB-1gvlA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		4 / 6 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.69A 2otvA-1gvlA:
28.3		 2otvA-1gvlA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.80A 2p16A-1gvlA:
25.6		 2p16A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.39A 2p16A-1gvlA:
25.6		 2p16A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		4 / 8 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.63A 2vinA-1gvlA:
7.4		 2vinA-1gvlA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.71A 2w26A-1gvlA:
6.0		 2w26A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.35A 2w26A-1gvlA:
6.0		 2w26A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 11 HIS A  57
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.57A 3gy3A-1gvlA:
27.6		 3gy3A-1gvlA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP4_A_MIIA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 9 ASN A 179
THR A 229
LEU A 212
ALA A  56
HIS A  91
 None
 1.34A 3kp4A-1gvlA:
undetectable
3kp4B-1gvlA:
undetectable		 3kp4A-1gvlA:
20.54
3kp4B-1gvlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		3 / 3 GLU A  77
PHE A  67
GLN A  80
 None
 0.47A 3r55A-1gvlA:
0.0		 3r55A-1gvlA:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.55A 3rxfA-1gvlA:
28.4		 3rxfA-1gvlA:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		4 / 5 GLY A 221
PRO A 225
ASN A 217
TYR A 172
 None
 1.01A 3u8qA-1gvlA:
undetectable		 3u8qA-1gvlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 ASN A 179
THR A 229
LEU A 212
ALA A  56
HIS A  91
 None
 1.39A 4ejwA-1gvlA:
undetectable		 4ejwA-1gvlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 1.04A 4qdjA-1gvlA:
undetectable		 4qdjA-1gvlA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1gvl KALLIKREIN 6
(Homo
sapiens) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.52A 4rn6B-1gvlA:
23.7		 4rn6B-1gvlA:
34.60