SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		4 / 8 GLY A  44
ILE A 212
ALA A  55
PHE A 228
 None
 0.93A 3aodA-1gvzA:
0.0		 3aodA-1gvzA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		5 / 8 VAL A  47
LEU A  46
ILE A 242
ARG A 107
LEU A 108
 None
None
ACT  A1250 ( 4.1A)
None
None
 1.28A 3kp6A-1gvzA:
undetectable
3kp6B-1gvzA:
undetectable		 3kp6A-1gvzA:
17.99
3kp6B-1gvzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 1.09A 3nvkI-1gvzA:
undetectable		 3nvkI-1gvzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		4 / 5 TYR A 137
ILE A 120
LEU A  46
LYS A 119
 None
 1.20A 3sueC-1gvzA:
9.5		 3sueC-1gvzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		4 / 8 ILE A 212
GLY A 211
VAL A  52
GLN A  30
 None
 0.90A 4acbB-1gvzA:
undetectable
4acbC-1gvzA:
undetectable		 4acbB-1gvzA:
16.12
4acbC-1gvzA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		5 / 7 PHE A 228
GLY A 197
THR A 213
ILE A 190
PHE A 223
 None
 1.20A 4ejjA-1gvzA:
undetectable		 4ejjA-1gvzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		5 / 12 ILE A  66
GLN A 110
LEU A 108
LEU A  68
ILE A 114
 None
 1.01A 4g1bD-1gvzA:
undetectable		 4g1bD-1gvzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		5 / 11 GLY A 196
GLY A 197
GLY A 216
ILE A 190
PHE A 228
 None
 1.14A 4qoiA-1gvzA:
undetectable
4qoiB-1gvzA:
undetectable		 4qoiA-1gvzA:
22.10
4qoiB-1gvzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		4 / 8 ILE A 242
VAL A  85
LEU A 108
ILE A  66
 ACT  A1250 ( 4.1A)
None
None
None
 0.81A 4r38A-1gvzA:
undetectable		 4r38A-1gvzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		4 / 8 ILE A 242
VAL A  85
LEU A 108
ILE A  66
 ACT  A1250 ( 4.1A)
None
None
None
 0.79A 4r38D-1gvzA:
undetectable		 4r38D-1gvzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		3 / 3 THR A 229
HIS A  48
LEU A 123
 None
ACT  A1250 (-4.5A)
None
 0.88A 5axdC-1gvzA:
undetectable		 5axdC-1gvzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1gvz KALLIKREIN-1E2
(Equus
caballus) 		4 / 8 SER A  86
PHE A  89
HIS A  48
ILE A 242
 None
None
ACT  A1250 (-4.5A)
ACT  A1250 ( 4.1A)
 0.79A 5vkqB-1gvzA:
undetectable
5vkqC-1gvzA:
undetectable		 5vkqB-1gvzA:
9.24
5vkqC-1gvzA:
9.24