SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1gwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 8 ALA A 177
LEU A 215
LEU A 216
LEU A 178
ALA A 219
 None
 1.26A 1e7cA-1gwcA:
3.6		 1e7cA-1gwcA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 8 ALA A 177
LEU A 216
ALA A 219
LYS A 220
 None
 0.75A 1e7cA-1gwcA:
3.6		 1e7cA-1gwcA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 VAL A 136
LEU A 139
ALA A 142
LEU A 165
ILE A 183
 None
 1.03A 1fk6A-1gwcA:
3.2		 1fk6A-1gwcA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 8 ARG A  20
PRO A  85
VAL A 158
GLY A 159
 None
 1.01A 1hrkB-1gwcA:
undetectable		 1hrkB-1gwcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 LEU A  73
LEU A 160
GLY A 166
ASP A 162
ALA A 205
 None
 1.14A 2br4F-1gwcA:
undetectable		 2br4F-1gwcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 7 LYS A  28
LEU A  30
LEU A  23
ILE A  71
 None
 0.97A 3gp0A-1gwcA:
undetectable		 3gp0A-1gwcA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 LEU A  59
TYR A  32
ALA A  24
LEU A  73
ALA A 204
 None
 1.33A 3ou7C-1gwcA:
undetectable		 3ou7C-1gwcA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 6 LEU A  30
LEU A  25
LEU A  87
LEU A  73
 None
 0.97A 3q1eA-1gwcA:
0.0
3q1eC-1gwcA:
undetectable		 3q1eA-1gwcA:
20.52
3q1eC-1gwcA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 6 PHE A  17
ARG A  20
PRO A  57
GLU A  68
SER A  69
 GTX  A1225 (-3.8A)
None
GTX  A1225 (-4.1A)
GTX  A1225 (-2.9A)
GTX  A1225 (-2.7A)
 0.47A 3vlnA-1gwcA:
23.9		 3vlnA-1gwcA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 7 ASP A 185
THR A 175
THR A 189
PHE A 184
 None
 1.03A 4ac9C-1gwcA:
undetectable		 4ac9C-1gwcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 6 ASP A 185
THR A 175
THR A 189
PHE A 184
 None
 0.99A 4acbC-1gwcA:
undetectable		 4acbC-1gwcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		3 / 3 TRP A 171
TRP A 113
THR A 175
 None
 1.47A 4bboB-1gwcA:
0.0		 4bboB-1gwcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		4 / 6 PHE A 199
ALA A 205
LEU A  23
THR A  19
 None
 1.12A 4dtzB-1gwcA:
0.0		 4dtzB-1gwcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 SER A  69
SER A 170
PHE A 184
PHE A 199
LEU A  27
 GTX  A1225 (-2.7A)
None
None
None
None
 1.39A 4zjlA-1gwcA:
0.0		 4zjlA-1gwcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 10 ALA A  98
ILE A  97
CYH A 146
GLY A 155
ASP A  91
 None
 1.43A 5ajqB-1gwcA:
undetectable		 5ajqB-1gwcA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 LEU A  73
LEU A  87
PHE A 199
THR A  19
ALA A 208
 None
 1.27A 5ieoA-1gwcA:
0.0		 5ieoA-1gwcA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 VAL A 168
TRP A 195
ALA A 204
VAL A 163
ALA A 164
 None
 1.08A 5kirA-1gwcA:
1.6		 5kirA-1gwcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 VAL A 168
TRP A 195
ALA A 204
VAL A 163
ALA A 164
 None
 1.08A 5kirB-1gwcA:
0.0		 5kirB-1gwcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 LEU A  88
PHE A 153
GLY A 154
LEU A 202
LEU A 192
 None
 1.21A 5y2tA-1gwcA:
undetectable		 5y2tA-1gwcA:
undetectable